| Title : Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides - Palikov_2018_Acta.Naturae_10_125 |
| Author(s) : Palikov VA , Terekhov SS , Palikova YA , Khokhlova ON , Kazakov VA , Dyachenko IA , Panteleev SV , Mokrushina YA , Knorre VD , Shamborant OG , Smirnov IV , Gabibov AG |
| Ref : Acta Naturae , 10 :125 , 2018 |
|
Abstract :
The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning. |
| PubMedSearch : Palikov_2018_Acta.Naturae_10_125 |
| PubMedID: 30713772 |
Palikov VA, Terekhov SS, Palikova YA, Khokhlova ON, Kazakov VA, Dyachenko IA, Panteleev SV, Mokrushina YA, Knorre VD, Shamborant OG, Smirnov IV, Gabibov AG (2018)
Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
Acta Naturae
10 :125
Palikov VA, Terekhov SS, Palikova YA, Khokhlova ON, Kazakov VA, Dyachenko IA, Panteleev SV, Mokrushina YA, Knorre VD, Shamborant OG, Smirnov IV, Gabibov AG (2018)
Acta Naturae
10 :125