| Title : Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase - Penning_2003_Bioorg.Med.Chem.Lett_13_1137 |
| Author(s) : Penning TD , Chandrakumar NS , Desai BN , Djuric SW , Gasiecki AF , Malecha JW , Miyashiro JM , Russell MA , Askonas LJ , Gierse JK , Harding EI , Highkin MK , Kachur JF , Kim SH , Villani-Price D , Pyla EY , Ghoreishi-Haack NS , Smith WG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :1137 , 2003 |
|
Abstract :
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excellent potency in our in vitro assays, as well as good oral activity in a mouse ex vivo assay. |
| PubMedSearch : Penning_2003_Bioorg.Med.Chem.Lett_13_1137 |
| PubMedID: 12643929 |
Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG (2003)
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase
Bioorganic & Medicinal Chemistry Lett
13 :1137
Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG (2003)
Bioorganic & Medicinal Chemistry Lett
13 :1137