| Title : 6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand - Ramunno_2005_Bioorg.Med.Chem.Lett_15_3237 |
| Author(s) : Ramunno A , Dukat M , Lee M , Young R , El-Zahabi M , Damaj MI , Martin B , Glennon RA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3237 , 2005 |
|
Abstract :
6-(2-Phenylethyl)nicotine (1b; K(i)=15 nM) was unexpectedly found to bind at alpha4beta2 nicotinic cholinergic (nACh) receptors. Although this compound failed to produce nicotine-like agonist action in several functional assays, 1b antagonized the antinociceptive effects of nicotine (mouse tail-flick assay) in a dose-dependent fashion when administered via an intrathecal route. |
| PubMedSearch : Ramunno_2005_Bioorg.Med.Chem.Lett_15_3237 |
| PubMedID: 15925512 |
Ramunno A, Dukat M, Lee M, Young R, El-Zahabi M, Damaj MI, Martin B, Glennon RA (2005)
6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand
Bioorganic & Medicinal Chemistry Lett
15 :3237
Ramunno A, Dukat M, Lee M, Young R, El-Zahabi M, Damaj MI, Martin B, Glennon RA (2005)
Bioorganic & Medicinal Chemistry Lett
15 :3237