Title : Characterization of the neuroligin gene family expression and evolution in zebrafish - Rissone_2010_Dev.Dyn_239_688
Author(s) : Rissone A , Sangiorgio L , Monopoli M , Beltrame M , Zucchi I , Bussolino F , Arese M , Cotelli F
Ref : Developmental Dynamics , 239 :688 , 2010
Abstract :

Neuroligins constitute a family of transmembrane proteins localized at the postsynaptic side of both excitatory and inhibitory synapses of the central nervous system. They are involved in synaptic function and maturation and recent studies have linked mutations in specific human Neuroligins to mental retardation and autism. We isolated the human Neuroligin homologs in Danio rerio. Next, we studied their gene structures and we reconstructed the evolution of the Neuroligin genes across vertebrate phyla. Using reverse-transcriptase polymerase chain reaction, we analyzed the expression and alternative splicing pattern of each gene during zebrafish embryonic development and in different adult organs. By in situ hybridization, we analyzed the temporal and spatial expression pattern during embryonic development and larval stages and we found that zebrafish Neuroligins are expressed throughout the nervous system. Globally, our results indicate that, during evolution, specific subfunctionalization events occurred within paralogous members of this gene family in zebrafish.

PubMedSearch : Rissone_2010_Dev.Dyn_239_688
PubMedID: 20034102
Gene_locus related to this paper: anoca-d2x2h9 , anoca-nlgn2 , anoca-nlgn4 , chick-d3wgl5 , chick-nlgn1 , chick-NLGN3 , ciosa-d2x2f8 , danre-1neur , danre-32neur , danre-d2x2g1 , danre-d2x2g3 , danre-d2x2g5 , danre-nlgn2a , danre-nlgn4a , gasac-d2x2j3 , gasac-d2x2j4 , gasac-nlgn2a , gasac-nlgn2b , gasac-nlgn4 , human-NLGN1 , human-NLGN3 , mondo-d2x2i6 , mondo-d2x2i8 , mondo-d2x2i9 , oryla-d2x2i4 , oryla-d2x2i5 , oryla-nlgn2 , takru-1neur , takru-2bneur , takru-3bneur , takru-nlgn2a , takru-nlgn3a , takru-nlgn4a , tetng-3neur , tetng-4neur , tetng-nlgn2b , tetng-nlgn2a , tetng-nlgn3b , xentr-d2x2k4 , xentr-d2x2k6 , xentr-d2x2k7

Related information

Gene_locus anoca-d2x2h9    anoca-nlgn2    anoca-nlgn4    chick-d3wgl5    chick-nlgn1    chick-NLGN3    ciosa-d2x2f8    danre-1neur    danre-32neur    danre-d2x2g1    danre-d2x2g3    danre-d2x2g5    danre-nlgn2a    danre-nlgn4a    gasac-d2x2j3    gasac-d2x2j4    gasac-nlgn2a    gasac-nlgn2b    gasac-nlgn4    human-NLGN1    human-NLGN3    mondo-d2x2i6    mondo-d2x2i8    mondo-d2x2i9    oryla-d2x2i4    oryla-d2x2i5    oryla-nlgn2    takru-1neur    takru-2bneur    takru-3bneur    takru-nlgn2a    takru-nlgn3a    takru-nlgn4a    tetng-3neur    tetng-4neur    tetng-nlgn2b    tetng-nlgn2a    tetng-nlgn3b    xentr-d2x2k4    xentr-d2x2k6    xentr-d2x2k7
Gene_locus_frgt anoca-d2x2h9    anoca-nlgn2    anoca-nlgn4    chick-d3wgl5    chick-nlgn1    chick-NLGN3    ciosa-d2x2f8    danre-1neur    danre-32neur    danre-d2x2g1    danre-d2x2g3    danre-d2x2g5    danre-nlgn2a    danre-nlgn4a    gasac-d2x2j3    gasac-d2x2j4    gasac-nlgn2a    gasac-nlgn2b    gasac-nlgn4    human-NLGN1    human-NLGN3    mondo-d2x2i6    mondo-d2x2i8    mondo-d2x2i9    oryla-d2x2i4    oryla-d2x2i5    oryla-nlgn2    takru-1neur    takru-2bneur    takru-3bneur    takru-nlgn2a    takru-nlgn3a    takru-nlgn4a    tetng-3neur    tetng-4neur    tetng-nlgn2b    tetng-nlgn2a    tetng-nlgn3b    xentr-d2x2k4    xentr-d2x2k6    xentr-d2x2k7    anoca-d2x2h7    gasac-d2x2j0    mondo-d2x2i7    oryla-d2x2i2    oryla-nlgn1    tetng-1neur    tetng-q4t9n1    xentr-d2x2k5

Citations formats

Rissone A, Sangiorgio L, Monopoli M, Beltrame M, Zucchi I, Bussolino F, Arese M, Cotelli F (2010)
Characterization of the neuroligin gene family expression and evolution in zebrafish
Developmental Dynamics 239 :688

Rissone A, Sangiorgio L, Monopoli M, Beltrame M, Zucchi I, Bussolino F, Arese M, Cotelli F (2010)
Developmental Dynamics 239 :688