human-NLGN3

Homo sapiens (Human) Neuroligin 3 KIAA1480

Comment

Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons. Neuroligins function as ligands for the neurexin family of cell surface receptors. Homo sapiens KIAA1480 . More recently it was cloned by Philibert et al. with some aa differences and with two alternative forms HNL3 HNLS3S. ChrX q21.1. In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a mutation R451C in the human-NLGN3 gene. arg451 in NLGN3, arg386 in BCHE, and arg395 in ACHE are conserved in mammalian species. In cellular transfection studies, De Jaco et al. (2006) inserted mutations homologous to the NLGN3 R451C mutation in BCHE and ACHE cDNAs and found that these mutations resulted in endoplasmic reticulum retention of the 2 proteins, similar to that observed with the NLGN3 R451C mutant protein. Tabuchi et al. (2007) introduced the R451C substitution in neuroligin-3 into mice. R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities. Unexpectedly these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion of neuroligin-3, in contrast, did not cause such changes, indicating that the R451C substitution represents a gain-of-function mutation. Tabuchi et al. (2007) concluded that increased inhibitory synaptic transmission may contribute to human autism spectrum disorders and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Recently Venkatesh et al. showed that neuronal activity promotes glioma growth through Neuroligin-3 secretion || Recently new findings support the neuroligin pathway in autism. In particular the R451C mutant mice (R451C_mouse-3neur<\/A> identical to human mutation R451C_human-NLGN3<\/A>) showed impaired social interactions but enhanced spatial learning abilities. Tabuchi et al.<\/A> Comments in Garber et al.<\/A>, Crawley et al.<\/A>

Relationship

Family : Neuroligin

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No substrate

No inhibitor

Sequence

Peptide

MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG VLGFLSTGDQ AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP LRQPSPQRGA GAPELGAAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV

References (40)

Title : Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory - Xiao_2024_Int.J.Mol.Sci_25_
Author(s) : Xiao H , Xu Y , Cui S , Wang JH
Ref : Int J Mol Sci , 25 : , 2024
PubMedID: 38255783
Gene_locus related to this paper: human-NLGN3

Title : Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation - Diamanti_2024_Traffic_25_e12930
Author(s) : Diamanti T , Trobiani L , Mautone L , Serafini F , Gioia R , Ferrucci L , Lauro C , Bianchi S , Perfetto C , Guglielmo S , Sollazzo R , Giorda E , Setini A , Ragozzino D , Miranda E , Comoletti D , Di Angelantonio S , Cacci E , De Jaco A
Ref : Traffic , 25 :e12930 , 2024
PubMedID: 38272450
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__
Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL
Ref : Psychopharmacology (Berl) , : , 2024
PubMedID: 38170320
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3(-\/y) mouse model of ASDs - Pizzarelli_2024_Front.Cell.Neurosci_17_1332179
Author(s) : Pizzarelli R , Pimpinella D , Jacobs C , Tartacca A , Kullolli U , Monyer H , Alberini CM , Griguoli M
Ref : Front Cell Neurosci , 17 :1332179 , 2024
PubMedID: 38298376
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses - Altas_2023_Biol.Psychiatry__
Author(s) : Altas B , Tuffy LP , Patrizi A , Dimova K , Soykan T , Brandenburg C , Romanowski AJ , Whitten JR , Robertson CD , Khim SN , Crutcher GW , Ambrozkiewicz MC , Yagensky O , Krueger-Burg D , Hammer M , Hsiao HH , Laskowski PR , Dyck L , Puche AC , Sassoe-Pognetto M , Chua JJE , Urlaub H , Jahn O , Brose N , Poulopoulos A
Ref : Biological Psychiatryry , : , 2023
PubMedID: 38154503
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Neuroligin-3 activates Akt-dependent Nrf2 cascade to protect osteoblasts from oxidative stress - Fan_2023_Free.Radic.Biol.Med__
Author(s) : Fan JB , Yuan K , Zhu XH , Cui SY , Yi H , Zhang W
Ref : Free Radic Biol Med , : , 2023
PubMedID: 37774803
Gene_locus related to this paper: human-NLGN3

Title : The Emerging Role of the Gut-Brain-Microbiota Axis in Neurodevelopmental Disorders - Hosie_2022_Adv.Exp.Med.Biol_1383_141
Author(s) : Hosie S , Abo-Shaban T , Lee CYQ , Matta SM , Shindler A , Gore R , Sharna SS , Herath M , Crack PJ , Franks AE , Hill-Yardin EL
Ref : Advances in Experimental Medicine & Biology , 1383 :141 , 2022
PubMedID: 36587154
Gene_locus related to this paper: human-NLGN3

Title : Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders - Zhang_2022_Front.Endocrinol.(Lausanne)_13_1067529
Author(s) : Zhang Z , Hou M , Ou H , Wang D , Li Z , Zhang H , Lu J
Ref : Front Endocrinol (Lausanne) , 13 :1067529 , 2022
PubMedID: 36479216
Gene_locus related to this paper: human-NLGN2 , human-NLGN3

Title : Genetic analysis of the postsynaptic transmembrane X-linked neuroligin 3 gene in autism - Hegde_2021_Genomics.Inform_19_e44
Author(s) : Hegde R , Hegde S , Kulkarni SS , Pandurangi A , Gai PB , Das KK
Ref : Genomics Inform , 19 :e44 , 2021
PubMedID: 35012288
Gene_locus related to this paper: human-NLGN3

Title : NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas - Dang_2021_Front.Cell.Dev.Biol_9_662763
Author(s) : Dang NN , Li XB , Zhang M , Han C , Fan XY , Huang SH
Ref : Front Cell Developmental Biology , 9 :662763 , 2021
PubMedID: 34485271
Gene_locus related to this paper: human-NLGN3

Title : Mice with an autism-associated R451C mutation in neuroligin-3 show a cautious but accurate response style in touchscreen attention tasks - Burrows_2021_Genes.Brain.Behav__e12757
Author(s) : Burrows EL , May C , Hill T , Churliov L , Johnson KA , Hannan AJ
Ref : Genes Brain Behav , :e12757 , 2021
PubMedID: 34085373
Gene_locus related to this paper: human-NLGN3

Title : An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum - Lai_2021_Front.Neural.Circuits_15_676891
Author(s) : Lai ESK , Nakayama H , Miyazaki T , Nakazawa T , Tabuchi K , Hashimoto K , Watanabe M , Kano M
Ref : Front Neural Circuits , 15 :676891 , 2021
PubMedID: 34262438
Gene_locus related to this paper: human-NLGN3

Title : Altered Caecal Neuroimmune Interactions in the Neuroligin-3(R451C) Mouse Model of Autism - Sharna_2020_Front.Cell.Neurosci_14_85
Author(s) : Sharna SS , Balasuriya GK , Hosie S , Nithianantharajah J , Franks AE , Hill-Yardin EL
Ref : Front Cell Neurosci , 14 :85 , 2020
PubMedID: 32327975
Gene_locus related to this paper: human-NLGN3

Title : Novel mutations in NLGN3 causing autism spectrum disorder and cognitive impairment - Quartier_2019_Hum.Mutat_40_2021
Author(s) : Quartier A , Courraud J , Thi Ha T , McGillivray G , Isidor B , Rose K , Drouot N , Savidan MA , Feger C , Jagline H , Chelly J , Shaw M , Laumonnier F , Gecz J , Mandel JL , Piton A
Ref : Hum Mutat , 40 :2021 , 2019
PubMedID: 31184401
Gene_locus related to this paper: human-NLGN3

Title : Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference - Norris_2019_Mol.Autism_10_42
Author(s) : Norris RHC , Churilov L , Hannan AJ , Nithianantharajah J
Ref : Mol Autism , 10 :42 , 2019
PubMedID: 31827744
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3 - Hosie_2019_Autism.Res_12_1043
Author(s) : Hosie S , Ellis M , Swaminathan M , Ramalhosa F , Seger GO , Balasuriya GK , Gillberg C , Rastam M , Churilov L , McKeown SJ , Yalcinkaya N , Urvil P , Savidge T , Bell CA , Bodin O , Wood J , Franks AE , Bornstein JC , Hill-Yardin EL
Ref : Autism Res , 12 :1043 , 2019
PubMedID: 31119867
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum - Martella_2018_Eur.J.Neurosci_47_701
Author(s) : Martella G , Meringolo M , Trobiani L , De Jaco A , Pisani A , Bonsi P
Ref : European Journal of Neuroscience , 47 :701 , 2018
PubMedID: 28921757
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion - Venkatesh_2015_Cell_161_803
Author(s) : Venkatesh HS , Johung TB , Caretti V , Noll A , Tang Y , Nagaraja S , Gibson EM , Mount CW , Polepalli J , Mitra SS , Woo PJ , Malenka RC , Vogel H , Bredel M , Mallick P , Monje M
Ref : Cell , 161 :803 , 2015
PubMedID: 25913192
Gene_locus related to this paper: human-NLGN3

Title : Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing - Redin_2014_J.Med.Genet_51_724
Author(s) : Redin C , Gerard B , Lauer J , Herenger Y , Muller J , Quartier A , Masurel-Paulet A , Willems M , Lesca G , El-Chehadeh S , Le Gras S , Vicaire S , Philipps M , Dumas M , Geoffroy V , Feger C , Haumesser N , Alembik Y , Barth M , Bonneau D , Colin E , Dollfus H , Doray B , Delrue MA , Drouin-Garraud V , Flori E , Fradin M , Francannet C , Goldenberg A , Lumbroso S , Mathieu-Dramard M , Martin-Coignard D , Lacombe D , Morin G , Polge A , Sukno S , Thauvin-Robinet C , Thevenon J , Doco-Fenzy M , Genevieve D , Sarda P , Edery P , Isidor B , Jost B , Olivier-Faivre L , Mandel JL , Piton A
Ref : Journal of Medical Genetics , 51 :724 , 2014
PubMedID: 25167861
Gene_locus related to this paper: human-NLGN3

Title : Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism - Corominas_2014_Nat.Commun_5_3650
Author(s) : Corominas R , Yang X , Lin GN , Kang S , Shen Y , Ghamsari L , Broly M , Rodriguez M , Tam S , Trigg SA , Fan C , Yi S , Tasan M , Lemmens I , Kuang X , Zhao N , Malhotra D , Michaelson JJ , Vacic V , Calderwood MA , Roth FP , Tavernier J , Horvath S , Salehi-Ashtiani K , Korkin D , Sebat J , Hill DE , Hao T , Vidal M , Iakoucheva LM
Ref : Nat Commun , 5 :3650 , 2014
PubMedID: 24722188
Gene_locus related to this paper: human-NLGN3

Title : Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function - Etherton_2011_Proc.Natl.Acad.Sci.U.S.A_108_13764
Author(s) : Etherton M , Foldy C , Sharma M , Tabuchi K , Liu X , Shamloo M , Malenka RC , Sudhof TC
Ref : Proc Natl Acad Sci U S A , 108 :13764 , 2011
PubMedID: 21808020
Gene_locus related to this paper: human-NLGN3

Title : Transsynaptic modulation of the synaptic vesicle cycle by cell-adhesion molecules - Gottmann_2008_J.Neurosci.Res_86_223
Author(s) : Gottmann K
Ref : Journal of Neuroscience Research , 86 :223 , 2008
PubMedID: 17787017
Gene_locus related to this paper: human-NLGN3

Title : Neuroscience. Autism's cause may reside in abnormalities at the synapse -
Author(s) : Garber K
Ref : Science , 317 :190 , 2007
PubMedID: 17626859
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Synaptic arrangement of the neuroligin\/beta-neurexin complex revealed by X-ray and neutron scattering - Comoletti_2007_Structure_15_693
Author(s) : Comoletti D , Grishaev A , Whitten AE , Tsigelny I , Taylor P , Trewhella J
Ref : Structure , 15 :693 , 2007
PubMedID: 17562316
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice - Tabuchi_2007_Science_318_71
Author(s) : Tabuchi K , Blundell J , Etherton MR , Hammer RE , Liu X , Powell CM , Sudhof TC
Ref : Science , 318 :71 , 2007
PubMedID: 17823315
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neurexin-neuroligin signaling in synapse development - Craig_2007_Curr.Opin.Neurobiol_17_43
Author(s) : Craig AM , Kang Y
Ref : Current Opinion in Neurobiology , 17 :43 , 2007
PubMedID: 17275284
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Medicine. Testing hypotheses about autism -
Author(s) : Crawley JN
Ref : Science , 318 :56 , 2007
PubMedID: 17916718
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses - Berninghausen_2007_J.Neurochem_103_1855
Author(s) : Berninghausen O , Rahman MA , Silva JP , Davletov B , Hopkins C , Ushkaryov YA
Ref : Journal of Neurochemistry , 103 :1855 , 2007
PubMedID: 17868325
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses - Budreck_2007_Eur.J.Neurosci_26_1738
Author(s) : Budreck EC , Scheiffele P
Ref : European Journal of Neuroscience , 26 :1738 , 2007
PubMedID: 17897391
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Adhesion molecules in the nervous system: structural insights into function and diversity - Shapiro_2007_Annu.Rev.Neurosci_30_451
Author(s) : Shapiro L , Love J , Colman DR
Ref : Annual Review of Neuroscience , 30 :451 , 2007
PubMedID: 17600523
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations - Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41
Author(s) : Yamakawa H , Oyama S , Mitsuhashi H , Sasagawa N , Uchino S , Kohsaka S , Ishiura S
Ref : Biochemical & Biophysical Research Communications , 355 :41 , 2007
PubMedID: 17292328
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients -
Author(s) : Yan J , Oliveira G , Coutinho A , Yang C , Feng J , Katz C , Sram J , Bockholt A , Jones IR , Craddock N , Cook EH, Jr. , Vicente A , Sommer SS
Ref : Mol Psychiatry , 10 :329 , 2005
PubMedID: 15622415
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : The DNA sequence of the human X chromosome - Ross_2005_Nature_434_325
Author(s) : Ross MT , Grafham DV , Coffey AJ , Scherer S , McLay K , Muzny D , Platzer M , Howell GR , Burrows C , Bird CP , Frankish A , Lovell FL , Howe KL , Ashurst JL , Fulton RS , Sudbrak R , Wen G , Jones MC , Hurles ME , Andrews TD , Scott CE , Searle S , Ramser J , Whittaker A , Deadman R , Carter NP , Hunt SE , Chen R , Cree A , Gunaratne P , Havlak P , Hodgson A , Metzker ML , Richards S , Scott G , Steffen D , Sodergren E , Wheeler DA , Worley KC , Ainscough R , Ambrose KD , Ansari-Lari MA , Aradhya S , Ashwell RI , Babbage AK , Bagguley CL , Ballabio A , Banerjee R , Barker GE , Barlow KF , Barrett IP , Bates KN , Beare DM , Beasley H , Beasley O , Beck A , Bethel G , Blechschmidt K , Brady N , Bray-Allen S , Bridgeman AM , Brown AJ , Brown MJ , Bonnin D , Bruford EA , Buhay C , Burch P , Burford D , Burgess J , Burrill W , Burton J , Bye JM , Carder C , Carrel L , Chako J , Chapman JC , Chavez D , Chen E , Chen G , Chen Y , Chen Z , Chinault C , Ciccodicola A , Clark SY , Clarke G , Clee CM , Clegg S , Clerc-Blankenburg K , Clifford K , Cobley V , Cole CG , Conquer JS , Corby N , Connor RE , David R , Davies J , Davis C , Davis J , Delgado O , Deshazo D , Dhami P , Ding Y , Dinh H , Dodsworth S , Draper H , Dugan-Rocha S , Dunham A , Dunn M , Durbin KJ , Dutta I , Eades T , Ellwood M , Emery-Cohen A , Errington H , Evans KL , Faulkner L , Francis F , Frankland J , Fraser AE , Galgoczy P , Gilbert J , Gill R , Glockner G , Gregory SG , Gribble S , Griffiths C , Grocock R , Gu Y , Gwilliam R , Hamilton C , Hart EA , Hawes A , Heath PD , Heitmann K , Hennig S , Hernandez J , Hinzmann B , Ho S , Hoffs M , Howden PJ , Huckle EJ , Hume J , Hunt PJ , Hunt AR , Isherwood J , Jacob L , Johnson D , Jones S , de Jong PJ , Joseph SS , Keenan S , Kelly S , Kershaw JK , Khan Z , Kioschis P , Klages S , Knights AJ , Kosiura A , Kovar-Smith C , Laird GK , Langford C , Lawlor S , Leversha M , Lewis L , Liu W , Lloyd C , Lloyd DM , Loulseged H , Loveland JE , Lovell JD , Lozado R , Lu J , Lyne R , Ma J , Maheshwari M , Matthews LH , McDowall J , Mclaren S , McMurray A , Meidl P , Meitinger T , Milne S , Miner G , Mistry SL , Morgan M , Morris S , Muller I , Mullikin JC , Nguyen N , Nordsiek G , Nyakatura G , O'Dell CN , Okwuonu G , Palmer S , Pandian R , Parker D , Parrish J , Pasternak S , Patel D , Pearce AV , Pearson DM , Pelan SE , Perez L , Porter KM , Ramsey Y , Reichwald K , Rhodes S , Ridler KA , Schlessinger D , Schueler MG , Sehra HK , Shaw-Smith C , Shen H , Sheridan EM , Shownkeen R , Skuce CD , Smith ML , Sotheran EC , Steingruber HE , Steward CA , Storey R , Swann RM , Swarbreck D , Tabor PE , Taudien S , Taylor T , Teague B , Thomas K , Thorpe A , Timms K , Tracey A , Trevanion S , Tromans AC , d'Urso M , Verduzco D , Villasana D , Waldron L , Wall M , Wang Q , Warren J , Warry GL , Wei X , West A , Whitehead SL , Whiteley MN , Wilkinson JE , Willey DL , Williams G , Williams L , Williamson A , Williamson H , Wilming L , Woodmansey RL , Wray PW , Yen J , Zhang J , Zhou J , Zoghbi H , Zorilla S , Buck D , Reinhardt R , Poustka A , Rosenthal A , Lehrach H , Meindl A , Minx PJ , Hillier LW , Willard HF , Wilson RK , Waterston RH , Rice CM , Vaudin M , Coulson A , Nelson DL , Weinstock G , Sulston JE , Durbin R , Hubbard T , Gibbs RA , Beck S , Rogers J , Bentley DR
Ref : Nature , 434 :325 , 2005
PubMedID: 15772651
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Analysis of four neuroligin genes as candidates for autism - Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285
Author(s) : Ylisaukko-oja T , Rehnstrom K , Auranen M , Vanhala R , Alen R , Kempas E , Ellonen P , Turunen JA , Makkonen I , Riikonen R , Nieminen-von Wendt T , von Wendt L , Peltonen L , Jarvela I
Ref : Eur J Hum Genet , 13 :1285 , 2005
PubMedID: 16077734
Gene_locus related to this paper: human-NLGN4Y , human-NLGN1 , human-NLGN3 , human-NLGN4X

Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27
Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T
Ref : Nat Genet , 34 :27 , 2003
PubMedID: 12669065
Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : The structure and expression of the human neuroligin-3 gene - Philibert_2000_Gene_246_303
Author(s) : Philibert RA , Winfield SL , Sandhu HK , Martin BM , Ginns EI
Ref : Gene , 246 :303 , 2000
PubMedID: 10767552
Gene_locus related to this paper: human-NLGN3

Title : Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro - Nagase_1999_DNA.Res_6_63
Author(s) : Nagase T , Ishikawa K , Suyama M , Kikuno R , Hirosawa M , Miyajima N , Tanaka A , Kotani H , Nomura N , Ohara O
Ref : DNA Research , 6 :63 , 1999
PubMedID: 10231032
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X , human-NLGN4Y

Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC
Ref : Science , 277 :1511 , 1997
PubMedID: 9278515
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X