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human-NLGN1

Homo sapiens (Human) Neuroligin 1 KIAA1070 protein

Comment

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. On chromosome 3 q26.31 twice the begining (first exons AC026099.3.74552.122231 and AC069531.6.1.37580.120969) and then 630 kb further the rest of sequence in one exon?! AC008120.17.1.138779.25769. A frameshift mutation, c.875_876insTT, in the neuroligin 1 gene (NLGN1) in a patient with AD and familial history of AD. The insertion generates a premature stop codon in the extracellular domain of NL1 (p.Thr271fs). Expression of mutant NL1 shows accumulation of truncated NL1 proteins in the endoplasmic reticulum

Relationship

Family : Neuroligin

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

Database

Sequence

Peptide

MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS EDCLYLNIYV PTEDVKRISK ECARKPGKKI CRKGGPLTKK HTDDLGDNDG AEDEDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGISASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ QPSPFSVDQR DYSTELSVTI AVGASLLFLN ILAFAALYYK KDKRRHDVHR RCSPQRTTTN DLTHAQEEEI MSLQMKHTDL DHECESIHPH EVVLRTACPP DYTLAMRRSP DDVPLMTPNT ITMIPNTIPG IQPLHTFNTF TGGQNNTLPH PHPHPHSHST TRV

References (19)

Title : Neuroligin-1 dependent phosphotyrosine signaling in excitatory synapse differentiation - Sziber_2024_Front.Mol.Neurosci_17_1359067
Author(s) : Sziber Z , Drouet A , Mondin M , Levet F , Thoumine O
Ref : Front Mol Neurosci , 17 :1359067 , 2024
Abstract :
PubMedSearch : Sziber_2024_Front.Mol.Neurosci_17_1359067
PubMedID: 38813439
Gene_locus related to this paper: human-NLGN1

Title : A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity - Arias-Aragon_2023_iScience_26_106868
Author(s) : Arias-Aragon F , Tristan-Clavijo E , Martinez-Gallego I , Robles-Lanuza E , Coatl-Cuaya H , Martin-Cuevas C , Sanchez-Hidalgo AC , Rodriguez-Moreno A , Martinez-Mir A , Scholl FG
Ref : iScience , 26 :106868 , 2023
Abstract :
PubMedSearch : Arias-Aragon_2023_iScience_26_106868
PubMedID: 37260747
Gene_locus related to this paper: human-NLGN1

Title : Epitope-tag-mediated synaptogenic activity in an engineered neurexin-1beta lacking the binding interface with neuroligin-1 - Hamid_2023_Biochem.Biophys.Res.Commun_658_141
Author(s) : Hamid SA , Imayasu M , Yoshida T , Tsutsui H
Ref : Biochemical & Biophysical Research Communications , 658 :141 , 2023
Abstract :
PubMedSearch : Hamid_2023_Biochem.Biophys.Res.Commun_658_141
PubMedID: 37030069
Gene_locus related to this paper: human-NLGN1

Title : Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder - Lee_2023_EBioMedicine_95_104746
Author(s) : Lee IH , Walker DI , Lin Y , Smith MR , Mandl KD , Jones DP , Kong SW
Ref : EBioMedicine , 95 :104746 , 2023
Abstract :
PubMedSearch : Lee_2023_EBioMedicine_95_104746
PubMedID: 37544204
Gene_locus related to this paper: human-NLGN1

Title : Graphene oxide disrupts the protein-protein interaction between Neuroligin\/NLG-1 and DLG-1 or MAGI-1 in nematode Caenorhabditis elegans - Zhao_2019_Sci.Total.Environ_700_134492
Author(s) : Zhao Y , Chen H , Yang Y , Wu Q , Wang D
Ref : Sci Total Environ , 700 :134492 , 2019
Abstract :
PubMedSearch : Zhao_2019_Sci.Total.Environ_700_134492
PubMedID: 31627046
Gene_locus related to this paper: caeel-NLGN1 , human-NLGN1

Title : A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation - Letellier_2018_Nat.Commun_9_3979
Author(s) : Letellier M , Sziber Z , Chamma I , Saphy C , Papasideri I , Tessier B , Sainlos M , Czondor K , Thoumine O
Ref : Nat Commun , 9 :3979 , 2018
Abstract :
PubMedSearch : Letellier_2018_Nat.Commun_9_3979
PubMedID: 30266896
Gene_locus related to this paper: human-NLGN1

Title : Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins - Elegheert_2017_Neuron_95_896
Author(s) : Elegheert J , Cvetkovska V , Clayton AJ , Heroven C , Vennekens KM , Smukowski SN , Regan MC , Jia W , Smith AC , Furukawa H , Savas JN , De Wit J , Begbie J , Craig AM , Aricescu AR
Ref : Neuron , 95 :896 , 2017
Abstract :
PubMedSearch : Elegheert_2017_Neuron_95_896
PubMedID: 28817804
Gene_locus related to this paper: human-NLGN1

Title : Functional significance of rare neuroligin 1 variants found in autism - Nakanishi_2017_PLoS.Genet_13_e1006940
Author(s) : Nakanishi M , Nomura J , Ji X , Tamada K , Arai T , Takahashi E , Bucan M , Takumi T
Ref : PLoS Genet , 13 :e1006940 , 2017
Abstract :
PubMedSearch : Nakanishi_2017_PLoS.Genet_13_e1006940
PubMedID: 28841651
Gene_locus related to this paper: human-NLGN1

Title : Characterization of the neuroligin gene family expression and evolution in zebrafish - Rissone_2010_Dev.Dyn_239_688
Author(s) : Rissone A , Sangiorgio L , Monopoli M , Beltrame M , Zucchi I , Bussolino F , Arese M , Cotelli F
Ref : Developmental Dynamics , 239 :688 , 2010
Abstract :
PubMedSearch : Rissone_2010_Dev.Dyn_239_688
PubMedID: 20034102
Gene_locus related to this paper: anoca-d2x2h9 , anoca-nlgn2 , anoca-nlgn4 , chick-d3wgl5 , chick-nlgn1 , chick-NLGN3 , ciosa-d2x2f8 , danre-1neur , danre-32neur , danre-d2x2g1 , danre-d2x2g3 , danre-d2x2g5 , danre-nlgn2a , danre-nlgn4a , gasac-d2x2j3 , gasac-d2x2j4 , gasac-nlgn2a , gasac-nlgn2b , gasac-nlgn4 , human-NLGN1 , human-NLGN3 , mondo-d2x2i6 , mondo-d2x2i8 , mondo-d2x2i9 , oryla-d2x2i4 , oryla-d2x2i5 , oryla-nlgn2 , takru-1neur , takru-2bneur , takru-3bneur , takru-nlgn2a , takru-nlgn3a , takru-nlgn4a , tetng-3neur , tetng-4neur , tetng-nlgn2b , tetng-nlgn2a , tetng-nlgn3b , xentr-d2x2k4 , xentr-d2x2k6 , xentr-d2x2k7

Title : The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions - Bottos_2009_Proc.Natl.Acad.Sci.U.S.A_106_20782
Author(s) : Bottos A , Destro E , Rissone A , Graziano S , Cordara G , Assenzio B , Cera MR , Mascia L , Bussolino F , Arese M
Ref : Proc Natl Acad Sci U S A , 106 :20782 , 2009
Abstract :
PubMedSearch : Bottos_2009_Proc.Natl.Acad.Sci.U.S.A_106_20782
PubMedID: 19926856
Gene_locus related to this paper: human-NLGN1

Title : Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion - Suckow_2008_Endocrinology_149_6006
Author(s) : Suckow AT , Comoletti D , Waldrop MA , Mosedale M , Egodage S , Taylor P , Chessler SD
Ref : Endocrinology , 149 :6006 , 2008
Abstract :
PubMedSearch : Suckow_2008_Endocrinology_149_6006
PubMedID: 18755801
Gene_locus related to this paper: human-NLGN1

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
Abstract :
PubMedSearch : Muzny_2006_Nature_440_1194
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin - Li_2006_Protein.Sci_15_2149
Author(s) : Li X , Zhang J , Cao Z , Wu J , Shi Y
Ref : Protein Science , 15 :2149 , 2006
Abstract :
PubMedSearch : Li_2006_Protein.Sci_15_2149
PubMedID: 16882988
Gene_locus related to this paper: human-NLGN1

Title : Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter - Nam_2005_Proc.Natl.Acad.Sci.U.S.A_102_6137
Author(s) : Nam CI , Chen L
Ref : Proc Natl Acad Sci U S A , 102 :6137 , 2005
Abstract :
PubMedSearch : Nam_2005_Proc.Natl.Acad.Sci.U.S.A_102_6137
PubMedID: 15837930
Gene_locus related to this paper: human-NLGN1

Title : Analysis of four neuroligin genes as candidates for autism - Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285
Author(s) : Ylisaukko-oja T , Rehnstrom K , Auranen M , Vanhala R , Alen R , Kempas E , Ellonen P , Turunen JA , Makkonen I , Riikonen R , Nieminen-von Wendt T , von Wendt L , Peltonen L , Jarvela I
Ref : Eur J Hum Genet , 13 :1285 , 2005
Abstract :
PubMedSearch : Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285
PubMedID: 16077734
Gene_locus related to this paper: human-NLGN4Y , human-NLGN1 , human-NLGN3 , human-NLGN4X

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
Abstract :
PubMedSearch : Ota_2004_Nat.Genet_36_40
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53

Title : Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons - Scheiffele_2000_Cell_101_657
Author(s) : Scheiffele P , Fan J , Choih J , Fetter R , Serafini T
Ref : Cell , 101 :657 , 2000
Abstract :
PubMedSearch : Scheiffele_2000_Cell_101_657
PubMedID: 10892652
Gene_locus related to this paper: human-NLGN1 , human-NLGN2

Title : Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro - Kikuno_1999_DNA.Res_6_197
Author(s) : Kikuno R , Nagase T , Ishikawa K , Hirosawa M , Miyajima N , Tanaka A , Kotani H , Nomura N , Ohara O
Ref : DNA Research , 6 :197 , 1999
Abstract :
PubMedSearch : Kikuno_1999_DNA.Res_6_197
PubMedID: 10470851
Gene_locus related to this paper: human-NLGN1

Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC
Ref : Science , 277 :1511 , 1997
Abstract :
PubMedSearch : Irie_1997_Science_277_1511
PubMedID: 9278515
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X