Salmon_1999_Neuroreport_10_849

Reference

Title : Modulation of morphine analgesia in alphaCGRP mutant mice - Salmon_1999_Neuroreport_10_849
Author(s) : Salmon AM , Damaj MI , Sekine S , Picciotto MR , Marubio L , Changeux JP
Ref : Neuroreport , 10 :849 , 1999
Abstract :

A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/alphaCGRP gene using homologous recombination. The mutant mice lack alphaCGRP mRNA. Furthermore CGRP immunoreactivity almost completely disappears from the spinal cord and is not at all observed in spinal ganglia and muscle synapses. However, motor end plates were still detected by acetylcholinesterase staining. Antinociceptive behavior tested by the tail flick and hot plate tests did not significantly differ in mutant and wild-type mice, except when challenged by morphine. Paradoxically, morphine analgesia was reduced in mutant mice compared with controls in the tail flick test, but not in the hot plate test. Thus, alphaCGRP differentially modulates opiate pain pathways.

PubMedSearch : Salmon_1999_Neuroreport_10_849
PubMedID: 10208559

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Citations formats

Salmon AM, Damaj MI, Sekine S, Picciotto MR, Marubio L, Changeux JP (1999)
Modulation of morphine analgesia in alphaCGRP mutant mice
Neuroreport 10 :849

Salmon AM, Damaj MI, Sekine S, Picciotto MR, Marubio L, Changeux JP (1999)
Neuroreport 10 :849