| Title : Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs - Sauerberg_1995_Life.Sci_56(11-12)_807 |
| Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Suzdak PD , Shannon HE , Bymaster FP , Calligaro DO , Mitch CH , Ward JS , Swedberg MD |
| Ref : Life Sciences , 56(11-12) :807 , 1995 |
|
Abstract :
Alkylthio-TZTPs (3-(3-alkylthio-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-met hylpyridines) and corresponding azabicyclic analogs were tested for m1 efficacy in cloned human m1 receptors and for antinociceptive activity in the mouse grid shock assay. The m1 (%PI) SAR were distinctly different from the analgesia and the salivation SAR, suggesting that analgesia is mediated by neither m1 nor M3 muscarinic receptors. |
| PubMedSearch : Sauerberg_1995_Life.Sci_56(11-12)_807 |
| PubMedID: 10188779 |
Sauerberg P, Olesen PH, Sheardown MJ, Suzdak PD, Shannon HE, Bymaster FP, Calligaro DO, Mitch CH, Ward JS, Swedberg MD (1995)
Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs
Life Sciences
56(11-12) :807
Sauerberg P, Olesen PH, Sheardown MJ, Suzdak PD, Shannon HE, Bymaster FP, Calligaro DO, Mitch CH, Ward JS, Swedberg MD (1995)
Life Sciences
56(11-12) :807