Calligaro DO

General

Full name : Calligaro David O

First name : David O

Mail : Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

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Country : USA

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References (38)

Title : Muscarinic mechanisms of antipsychotic atypicality - Bymaster_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_1125
Author(s) : Bymaster FP , Felder CC , Tzavara E , Nomikos GG , Calligaro DO , McKinzie DL
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 27 :1125 , 2003
Abstract :
PubMedSearch : Bymaster_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_1125
PubMedID: 14642972

Title : The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance - Rasmussen_2001_Schizophr.Res_49_193
Author(s) : Rasmussen T , Fink-Jensen A , Sauerberg P , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP
Ref : Schizophr Res , 49 :193 , 2001
Abstract :
PubMedSearch : Rasmussen_2001_Schizophr.Res_49_193
PubMedID: 11343877

Title : A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data - Kennedy_2001_Int.J.Geriatr.Psychiatry_16 Suppl 1_S33
Author(s) : Kennedy JS , Bymaster FP , Schuh L , Calligaro DO , Nomikos G , Felder CC , Bernauer M , Kinon BJ , Baker RW , Hay D , Roth HJ , Dossenbach M , Kaiser C , Beasley CM , Holcombe JH , Effron MB , Breier A
Ref : Int J Geriatr Psychiatry , 16 Suppl 1 :S33 , 2001
Abstract :
PubMedSearch : Kennedy_2001_Int.J.Geriatr.Psychiatry_16 Suppl 1_S33
PubMedID: 11748788

Title : Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo - Bymaster_2001_Brain.Res_916_165
Author(s) : Bymaster FP , Carter PA , DeLapp NW , Calligaro DO , Felder CC
Ref : Brain Research , 916 :165 , 2001
Abstract :
PubMedSearch : Bymaster_2001_Brain.Res_916_165
PubMedID: 11597604

Title : Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice - Rasmussen_2000_Eur.J.Pharmacol_402_241
Author(s) : Rasmussen T , Sauerberg P , Nielsen EB , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP , Fink-Jensen A
Ref : European Journal of Pharmacology , 402 :241 , 2000
Abstract :
PubMedSearch : Rasmussen_2000_Eur.J.Pharmacol_402_241
PubMedID: 10958890

Title : Poster: Muscarinic receptor characterization and neurochemical effects of the antipsychotic-like muscarinic agonist PTAC -
Author(s) : Bymaster FP , Shannon HE , DeLapp NW , Calligaro DO , Perry KW , Zhang W , Rasmussen K , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Life Sciences , 64 :579 , 1999
PubMedID:

Title : Poster: Behavioral and electrophysiological effects of the antipsychotic-like muscarinic agonist PTAC -
Author(s) : Shannon HE , Bymaster FP , Rasmussen K , DeLapp NW , Calligaro DO , Perry KW , Mitch CH , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Life Sciences , 64 :587 , 1999
PubMedID:

Title : Direct pharmacological comparison of the muscarinic receptors mediating relaxation and contraction in the rabbit thoracic aorta - Sawyer_1999_Gen.Pharmacol_32_445
Author(s) : Sawyer BD , Bymaster FP , Calligaro DO , Falcone J , Mitch CH , Ward JS , Whitesitt CA , Shannon HE
Ref : General Pharmacology , 32 :445 , 1999
Abstract :
PubMedSearch : Sawyer_1999_Gen.Pharmacol_32_445
PubMedID: 10323485

Title : Potential role of muscarinic receptors in schizophrenia - Bymaster_1999_Life.Sci_64(6-7)_527
Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Ward JS , Calligaro DO , Mitch CH , Whitesitt CA , Ludvigsen TS , Sheardown MJ , Swedberg MD , Rasmussen T , Olesen PH , Jeppesen L , Sauerberg P , Fink-Jensen A
Ref : Life Sciences , 64 :527 , 1999
Abstract :
PubMedSearch : Bymaster_1999_Life.Sci_64(6-7)_527
PubMedID: 10069519

Title : Poster: Determination of the intrinsic functional muscarinic activity of xanomeline -
Author(s) : Falcone JF , Bymaster FP , Butler T , Thomsen C , Calligaro DO , Shannon HE , Whitesitt C , Ward J , Sheardown M , Fink-Jensen A , Jeppesen L , Sauerberg P , DeLapp NC
Ref : Life Sciences , 64 :579 , 1999
PubMedID:

Title : Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats - Shannon_1999_J.Pharmacol.Exp.Ther_290_901
Author(s) : Shannon HE , Hart JC , Bymaster FP , Calligaro DO , DeLapp NW , Mitch CH , Ward JS , Fink-Jensen A , Sauerberg P , Jeppesen L , Sheardown MJ , Swedberg MD
Ref : Journal of Pharmacology & Experimental Therapeutics , 290 :901 , 1999
Abstract :
PubMedSearch : Shannon_1999_J.Pharmacol.Exp.Ther_290_901
PubMedID: 10411607

Title : Poster: Muscarinic agonists with antipsychotic-like activity. Structure activity-relationships of 1,2,5-thiadiazole analogues with functioally dopamine antagonist activity -
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE
Ref : Life Sciences , 64 :555 , 1999
PubMedID:

Title : Poster: New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof -
Author(s) : Jeppesen L , Sauerberg P , Olesen PH , Sheardown MJ , Thomsen C , Rasmussen T , Fink-Jensen A , Christensen MS , Ward JS , Whitesitt C , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE
Ref : Life Sciences , 64 :555 , 1999
PubMedID:

Title : 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives - Jeppesen_1999_J.Med.Chem_42_1999
Author(s) : Jeppesen L , Olesen PH , Hansen L , Sheardown MJ , Thomsen C , Rasmussen T , Jensen AF , Christensen MS , Rimvall K , Ward JS , Whitesitt CA , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE , Sauerberg P
Ref : Journal of Medicinal Chemistry , 42 :1999 , 1999
Abstract :
PubMedSearch : Jeppesen_1999_J.Med.Chem_42_1999
PubMedID: 10354408

Title : Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats - Fink-Jensen_1998_Neuroreport_9_3481
Author(s) : Fink-Jensen A , Kristensen P , Shannon HE , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Thomsen C , Rasmusseen T , Sheardown MJ , Jeppesen L , Sauerberg P , Bymaster FP
Ref : Neuroreport , 9 :3481 , 1998
Abstract :
PubMedSearch : Fink-Jensen_1998_Neuroreport_9_3481
PubMedID: 9855303

Title : Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane - Bymaster_1998_Eur.J.Pharmacol_356_109
Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Mitch CH , Ward JS , Calligaro DO , Ludvigsen TS , Sheardown MJ , Olesen PH , Swedberg MD , Sauerberg P , Fink-Jensen A
Ref : European Journal of Pharmacology , 356 :109 , 1998
Abstract :
PubMedSearch : Bymaster_1998_Eur.J.Pharmacol_356_109
PubMedID: 9774240

Title : Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity - Sauerberg_1998_J.Med.Chem_41_4378
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Rimvall K , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE
Ref : Journal of Medicinal Chemistry , 41 :4378 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_J.Med.Chem_41_4378
PubMedID: 9784113

Title : Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation - Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Sheardown MJ , Fink-Jensen A , Rasmussen T , Rimvall K , Shannon HE , Bymaster FP , DeLapp NW , Calligaro DO , Ward JS , Whitesitt CA , Thomsen C
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2897 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897
PubMedID: 9873644

Title : Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity - Sauerberg_1998_J.Med.Chem_41_109
Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Rimvall K , Thogersen H , Shannon HE , Sawyer BD , Ward JS , Bymaster FP , DeLapp NW , Calligaro DO , Swedberg MD
Ref : Journal of Medicinal Chemistry , 41 :109 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_J.Med.Chem_41_109
PubMedID: 9438027

Title : Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects - Bymaster_1998_Brain.Res_795_179
Author(s) : Bymaster FP , Carter PA , Peters SC , Zhang W , Ward JS , Mitch CH , Calligaro DO , Whitesitt CA , DeLapp NC , Shannon HE , Rimvall K , Jeppesen L , Sheardown MJ , Fink-Jensen A , Sauerberg P
Ref : Brain Research , 795 :179 , 1998
Abstract :
PubMedSearch : Bymaster_1998_Brain.Res_795_179
PubMedID: 9622623

Title : 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists - Ward_1998_J.Med.Chem_41_379
Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Mitch CH , Whitesitt CA , Brunsting D , Sheardown MJ , Olesen PH , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Journal of Medicinal Chemistry , 41 :379 , 1998
Abstract :
PubMedSearch : Ward_1998_J.Med.Chem_41_379
PubMedID: 9464368

Title : Poster: Stimulation of phosphoinositide hydrolysis in vivo by xanomeline and other muscarinic agents -
Author(s) : Bymaster FP , Carter PA , Shannon HE , DeLapp NC , Whitesitt CA , Ward JS , Calligaro DO , Mitch CH , Sheardown MJ , Swedberg MD , Rimvall K , Fink-Jensen A , Jeppesen L , Sauerberg P
Ref : Life Sciences , 60 :1165 , 1997
PubMedID:

Title : Poster: The tetrahydropyridine ring confers optimal M-1 selectivity and blood brain barrier penetration among hexyloxy-1,2,5-thiadiazole azacycles -
Author(s) : Ward JS , Merritt L , Stratford R , Brown TJ , Wijayaratne R , Szewczyk SP , Calligaro DO , Bymaster FP , Shannon HE , Mitch CH , Johnson DW , Wikel JH , Olesen PH , Sheardown MJ , Swedberg MD , Sauerberg P
Ref : Life Sciences , 60 :1165 , 1997
PubMedID:

Title : Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome - Mitch_1997_J.Med.Chem_40_538
Author(s) : Mitch CH , Brown TJ , Bymaster FP , Calligaro DO , Dieckman D , Merrit L , Peters SC , Quimby SJ , Shannon HE , Shipley LA , Ward JS , Hansen K , Olesen PH , Sauerberg P , Sheardown MJ , Swedberg MD , Suzdak P , Greenwood B
Ref : Journal of Medicinal Chemistry , 40 :538 , 1997
Abstract :
PubMedSearch : Mitch_1997_J.Med.Chem_40_538
PubMedID: 9046345

Title : Pharmacology of butylthio[2.2.2] (LY297802\/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity - Shannon_1997_J.Pharmacol.Exp.Ther_281_884
Author(s) : Shannon HE , Sheardown MJ , Bymaster FP , Calligaro DO , DeLapp NW , Gidda J , Mitch CH , Sawyer BD , Stengel PW , Ward JS , Wong DT , Olesen PH , Suzdak PD , Sauerberg P , Swedberg MD
Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :884 , 1997
Abstract :
PubMedSearch : Shannon_1997_J.Pharmacol.Exp.Ther_281_884
PubMedID: 9152398

Title : In vivo pharmacology of butylthio[2.2.2] (LY297802 \/ NNC11-1053), an orally acting antinociceptive muscarinic agonist - Shannon_1997_Life.Sci_60(13-14)_969
Author(s) : Shannon HE , Womer DE , Bymaster FP , Calligaro DO , DeLapp NC , Mitch CH , Ward JS , Whitesitt CA , Swedberg MD , Sheardown MJ , Fink-Jensen A , Olesen PH , Rimvall K , Sauerberg P
Ref : Life Sciences , 60 :969 , 1997
Abstract :
PubMedSearch : Shannon_1997_Life.Sci_60(13-14)_969
PubMedID: 9121363

Title : Butylthio[2.2.2] (NNC 11-1053\/LY297802): an orally active muscarinic agonist analgesic - Swedberg_1997_J.Pharmacol.Exp.Ther_281_876
Author(s) : Swedberg MD , Sheardown MJ , Sauerberg P , Olesen PH , Suzdak PD , Hansen KT , Bymaster FP , Ward JS , Mitch CH , Calligaro DO , DeLapp NW , Shannon HE
Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :876 , 1997
Abstract :
PubMedSearch : Swedberg_1997_J.Pharmacol.Exp.Ther_281_876
PubMedID: 9152397

Title : Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs - Sauerberg_1995_Life.Sci_56(11-12)_807
Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Suzdak PD , Shannon HE , Bymaster FP , Calligaro DO , Mitch CH , Ward JS , Swedberg MD
Ref : Life Sciences , 56(11-12) :807 , 1995
Abstract :
PubMedSearch : Sauerberg_1995_Life.Sci_56(11-12)_807
PubMedID: 10188779

Title : Poster: 3-(3-Hexyloxypyrazinyl)quinuclidine as a functionally selective M1 agonist -
Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Sawyer BD , Mitch CH , Sheardown MJ , Olesen PH , Suzdak PD , Swedberg MD , Sauerberg P
Ref : Life Sciences , 56(11-12) :1003 , 1995
PubMedID:

Title : Poster: Sidechain steric bulk and muscarinic agonist sar in alkoxy-TZTP's -
Author(s) : Mitch CH , Bymaster FP , Calligaro DO , Quimby SJ , Sawyer BD , Ward JS , Olesen PH , Sauerberg P , Sheardown MJ , Suzdak PD , Swedberg MD , Shannon HE
Ref : Life Sciences , 56(11-12) :1004 , 1995
PubMedID:

Title : Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles - Ward_1995_J.Med.Chem_38_3469
Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Sawyer BD , Mitch CH , Deeter JB , Peters SC , Sheardown MJ , Olesen PH , Swedberg MD , Sauerberg P
Ref : Journal of Medicinal Chemistry , 38 :3469 , 1995
Abstract :
PubMedSearch : Ward_1995_J.Med.Chem_38_3469
PubMedID: 7658434

Title : Poster: Arachidonic acid release by muscarinic agents in cell lines transfected with muscarinic receptors -
Author(s) : Bymaster FP , Falcone JF , Shannon HE , Calligaro DO
Ref : Life Sciences , 56(11-12) :1016 , 1995
PubMedID:

Title : Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708\/NNC11-0232) - Bymaster_1994_J.Pharmacol.Exp.Ther_269_282
Author(s) : Bymaster FP , Wong DT , Mitch CH , Ward JS , Calligaro DO , Schoepp DD , Shannon HE , Sheardown MJ , Olesen PH , Suzdak PD , Swedberg MD , Sauerberg P , et al.
Ref : Journal of Pharmacology & Experimental Therapeutics , 269 :282 , 1994
Abstract :
PubMedSearch : Bymaster_1994_J.Pharmacol.Exp.Ther_269_282
PubMedID: 7909558

Title : Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors - Shannon_1994_J.Pharmacol.Exp.Ther_269_271
Author(s) : Shannon HE , Bymaster FP , Calligaro DO , Greenwood B , Mitch CH , Sawyer BD , Ward JS , Wong DT , Olesen PH , Sheardown MJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 269 :271 , 1994
Abstract :
PubMedSearch : Shannon_1994_J.Pharmacol.Exp.Ther_269_271
PubMedID: 7909557

Title : Poster: Alkoxy sar around the functionally M1 selective agonist hexyloxy-TZTP -
Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Suzdak PD , Swedberg MD , Mitch CH , Ward JS , Calligaro DO , Sawyer BD , Bymaster FP , Shannon HE
Ref : Life Sciences , 52(5-6) :549 , 1993
PubMedID:

Title : Poster: Muscarinic analgesia is mediated by non-M1 muscarinic receptors -
Author(s) : Swedberg MD , Sheardown MJ , Sauerberg P , Olesen PH , Suzdak PD , Shannon HE , Bymaster FP , Ward JS , Mitch CH , Calligaro DO
Ref : Life Sciences , 52(5-6) :594 , 1993
PubMedID:

Title : Poster: 3-hexyloxy analogs of TZTP are potent and selective M1 agonists in brain of rat in vivo -
Author(s) : Bymaster FP , Wong DT , Mitch CH , Ward JS , Calligaro DO , Shannon HE , Sawyer BD , Quimby SJ , Sheardown MJ , Olesen PH , Suzdak PD , Sauerberg P
Ref : Life Sciences , 52(5-6) :593 , 1993
PubMedID:

Title : Poster: Hexyloxy-TZTP: A potent and selective M1 agonist in-vitro -
Author(s) : Mitch CH , Bymaster FP , Calligaro DO , Quimby SJ , Sawyer BD , Shannon HE , Ward JS , Olesen PH , Sauerberg P , Sheardown MJ , Suzdak PD
Ref : Life Sciences , 52(5-6) :550 , 1993
PubMedID: