Full name : Ward John S
First name : John S
Mail : Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
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Country : USA
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Comment
| Title : The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance - Rasmussen_2001_Schizophr.Res_49_193 |
| Author(s) : Rasmussen T , Fink-Jensen A , Sauerberg P , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP |
| Ref : Schizophr Res , 49 :193 , 2001 |
| Abstract : |
| PubMedSearch : Rasmussen_2001_Schizophr.Res_49_193 |
| PubMedID: 11343877 |
| Title : Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice - Rasmussen_2000_Eur.J.Pharmacol_402_241 |
| Author(s) : Rasmussen T , Sauerberg P , Nielsen EB , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP , Fink-Jensen A |
| Ref : European Journal of Pharmacology , 402 :241 , 2000 |
| Abstract : |
| PubMedSearch : Rasmussen_2000_Eur.J.Pharmacol_402_241 |
| PubMedID: 10958890 |
| Title : Therapeutic opportunities for muscarinic receptors in the central nervous system - |
| Author(s) : Felder CC , Bymaster FP , Ward JS , DeLapp NC |
| Ref : Journal of Medicinal Chemistry , 43 :4333 , 2000 |
| PubMedID: 11087557 |
| Title : Poster: Muscarinic agonists with antipsychotic-like activity. Structure activity-relationships of 1,2,5-thiadiazole analogues with functioally dopamine antagonist activity - |
| Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE |
| Ref : Life Sciences , 64 :555 , 1999 |
| PubMedID: |
| Title : Poster: New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof - |
| Author(s) : Jeppesen L , Sauerberg P , Olesen PH , Sheardown MJ , Thomsen C , Rasmussen T , Fink-Jensen A , Christensen MS , Ward JS , Whitesitt C , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE |
| Ref : Life Sciences , 64 :555 , 1999 |
| PubMedID: |
| Title : 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives - Jeppesen_1999_J.Med.Chem_42_1999 |
| Author(s) : Jeppesen L , Olesen PH , Hansen L , Sheardown MJ , Thomsen C , Rasmussen T , Jensen AF , Christensen MS , Rimvall K , Ward JS , Whitesitt CA , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE , Sauerberg P |
| Ref : Journal of Medicinal Chemistry , 42 :1999 , 1999 |
| Abstract : |
| PubMedSearch : Jeppesen_1999_J.Med.Chem_42_1999 |
| PubMedID: 10354408 |
| Title : Poster: Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice - |
| Author(s) : Zhang L , Shannon HE , Bymaster FP , DeLapp NW , Womer DE , Mitch CH , Ward JS , Olesen PH , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P |
| Ref : Life Sciences , 64 :587 , 1999 |
| PubMedID: |
| Title : Poster: Muscarinic receptor characterization and neurochemical effects of the antipsychotic-like muscarinic agonist PTAC - |
| Author(s) : Bymaster FP , Shannon HE , DeLapp NW , Calligaro DO , Perry KW , Zhang W , Rasmussen K , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P |
| Ref : Life Sciences , 64 :579 , 1999 |
| PubMedID: |
| Title : Poster: Behavioral and electrophysiological effects of the antipsychotic-like muscarinic agonist PTAC - |
| Author(s) : Shannon HE , Bymaster FP , Rasmussen K , DeLapp NW , Calligaro DO , Perry KW , Mitch CH , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P |
| Ref : Life Sciences , 64 :587 , 1999 |
| PubMedID: |
| Title : Direct pharmacological comparison of the muscarinic receptors mediating relaxation and contraction in the rabbit thoracic aorta - Sawyer_1999_Gen.Pharmacol_32_445 |
| Author(s) : Sawyer BD , Bymaster FP , Calligaro DO , Falcone J , Mitch CH , Ward JS , Whitesitt CA , Shannon HE |
| Ref : General Pharmacology , 32 :445 , 1999 |
| Abstract : |
| PubMedSearch : Sawyer_1999_Gen.Pharmacol_32_445 |
| PubMedID: 10323485 |
| Title : Potential role of muscarinic receptors in schizophrenia - Bymaster_1999_Life.Sci_64(6-7)_527 |
| Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Ward JS , Calligaro DO , Mitch CH , Whitesitt CA , Ludvigsen TS , Sheardown MJ , Swedberg MD , Rasmussen T , Olesen PH , Jeppesen L , Sauerberg P , Fink-Jensen A |
| Ref : Life Sciences , 64 :527 , 1999 |
| Abstract : |
| PubMedSearch : Bymaster_1999_Life.Sci_64(6-7)_527 |
| PubMedID: 10069519 |
| Title : Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats - Shannon_1999_J.Pharmacol.Exp.Ther_290_901 |
| Author(s) : Shannon HE , Hart JC , Bymaster FP , Calligaro DO , DeLapp NW , Mitch CH , Ward JS , Fink-Jensen A , Sauerberg P , Jeppesen L , Sheardown MJ , Swedberg MD |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 290 :901 , 1999 |
| Abstract : |
| PubMedSearch : Shannon_1999_J.Pharmacol.Exp.Ther_290_901 |
| PubMedID: 10411607 |
| Title : 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists - Ward_1998_J.Med.Chem_41_379 |
| Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Mitch CH , Whitesitt CA , Brunsting D , Sheardown MJ , Olesen PH , Swedberg MD , Jeppesen L , Sauerberg P |
| Ref : Journal of Medicinal Chemistry , 41 :379 , 1998 |
| Abstract : |
| PubMedSearch : Ward_1998_J.Med.Chem_41_379 |
| PubMedID: 9464368 |
| Title : Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats - Fink-Jensen_1998_Neuroreport_9_3481 |
| Author(s) : Fink-Jensen A , Kristensen P , Shannon HE , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Thomsen C , Rasmusseen T , Sheardown MJ , Jeppesen L , Sauerberg P , Bymaster FP |
| Ref : Neuroreport , 9 :3481 , 1998 |
| Abstract : |
| PubMedSearch : Fink-Jensen_1998_Neuroreport_9_3481 |
| PubMedID: 9855303 |
| Title : Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane - Bymaster_1998_Eur.J.Pharmacol_356_109 |
| Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Mitch CH , Ward JS , Calligaro DO , Ludvigsen TS , Sheardown MJ , Olesen PH , Swedberg MD , Sauerberg P , Fink-Jensen A |
| Ref : European Journal of Pharmacology , 356 :109 , 1998 |
| Abstract : |
| PubMedSearch : Bymaster_1998_Eur.J.Pharmacol_356_109 |
| PubMedID: 9774240 |
| Title : Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity - Sauerberg_1998_J.Med.Chem_41_4378 |
| Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Rimvall K , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE |
| Ref : Journal of Medicinal Chemistry , 41 :4378 , 1998 |
| Abstract : |
| PubMedSearch : Sauerberg_1998_J.Med.Chem_41_4378 |
| PubMedID: 9784113 |
| Title : Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation - Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897 |
| Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Sheardown MJ , Fink-Jensen A , Rasmussen T , Rimvall K , Shannon HE , Bymaster FP , DeLapp NW , Calligaro DO , Ward JS , Whitesitt CA , Thomsen C |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2897 , 1998 |
| Abstract : |
| PubMedSearch : Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897 |
| PubMedID: 9873644 |
| Title : Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity - Sauerberg_1998_J.Med.Chem_41_109 |
| Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Rimvall K , Thogersen H , Shannon HE , Sawyer BD , Ward JS , Bymaster FP , DeLapp NW , Calligaro DO , Swedberg MD |
| Ref : Journal of Medicinal Chemistry , 41 :109 , 1998 |
| Abstract : |
| PubMedSearch : Sauerberg_1998_J.Med.Chem_41_109 |
| PubMedID: 9438027 |
| Title : Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects - Bymaster_1998_Brain.Res_795_179 |
| Author(s) : Bymaster FP , Carter PA , Peters SC , Zhang W , Ward JS , Mitch CH , Calligaro DO , Whitesitt CA , DeLapp NC , Shannon HE , Rimvall K , Jeppesen L , Sheardown MJ , Fink-Jensen A , Sauerberg P |
| Ref : Brain Research , 795 :179 , 1998 |
| Abstract : |
| PubMedSearch : Bymaster_1998_Brain.Res_795_179 |
| PubMedID: 9622623 |
| Title : Pharmacology of butylthio[2.2.2] (LY297802\/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity - Shannon_1997_J.Pharmacol.Exp.Ther_281_884 |
| Author(s) : Shannon HE , Sheardown MJ , Bymaster FP , Calligaro DO , DeLapp NW , Gidda J , Mitch CH , Sawyer BD , Stengel PW , Ward JS , Wong DT , Olesen PH , Suzdak PD , Sauerberg P , Swedberg MD |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :884 , 1997 |
| Abstract : |
| PubMedSearch : Shannon_1997_J.Pharmacol.Exp.Ther_281_884 |
| PubMedID: 9152398 |
| Title : In vivo pharmacology of butylthio[2.2.2] (LY297802 \/ NNC11-1053), an orally acting antinociceptive muscarinic agonist - Shannon_1997_Life.Sci_60(13-14)_969 |
| Author(s) : Shannon HE , Womer DE , Bymaster FP , Calligaro DO , DeLapp NC , Mitch CH , Ward JS , Whitesitt CA , Swedberg MD , Sheardown MJ , Fink-Jensen A , Olesen PH , Rimvall K , Sauerberg P |
| Ref : Life Sciences , 60 :969 , 1997 |
| Abstract : |
| PubMedSearch : Shannon_1997_Life.Sci_60(13-14)_969 |
| PubMedID: 9121363 |
| Title : M1 receptor agonist activity is not a requirement for muscarinic antinociception - Sheardown_1997_J.Pharmacol.Exp.Ther_281_868 |
| Author(s) : Sheardown MJ , Shannon HE , Swedberg MD , Suzdak PD , Bymaster FP , Olesen PH , Mitch CH , Ward JS , Sauerberg P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :868 , 1997 |
| Abstract : |
| PubMedSearch : Sheardown_1997_J.Pharmacol.Exp.Ther_281_868 |
| PubMedID: 9152396 |
| Title : Butylthio[2.2.2] (NNC 11-1053\/LY297802): an orally active muscarinic agonist analgesic - Swedberg_1997_J.Pharmacol.Exp.Ther_281_876 |
| Author(s) : Swedberg MD , Sheardown MJ , Sauerberg P , Olesen PH , Suzdak PD , Hansen KT , Bymaster FP , Ward JS , Mitch CH , Calligaro DO , DeLapp NW , Shannon HE |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :876 , 1997 |
| Abstract : |
| PubMedSearch : Swedberg_1997_J.Pharmacol.Exp.Ther_281_876 |
| PubMedID: 9152397 |
| Title : Poster: Conformationally constrained analogs of the muscarinic agonist methylthio-TZTP. Synthesis, receptor affinity and analgesic activity - |
| Author(s) : Sauerberg P , Olesen PH , Thogersen H , Nielsen S , Sheardown MJ , Rimvall K , Shannon HE , Ward JS , Mitch CH , Bymaster FP , Swedberg MD |
| Ref : Life Sciences , 60 :1164 , 1997 |
| PubMedID: |
| Title : Poster: Stimulation of phosphoinositide hydrolysis in vivo by xanomeline and other muscarinic agents - |
| Author(s) : Bymaster FP , Carter PA , Shannon HE , DeLapp NC , Whitesitt CA , Ward JS , Calligaro DO , Mitch CH , Sheardown MJ , Swedberg MD , Rimvall K , Fink-Jensen A , Jeppesen L , Sauerberg P |
| Ref : Life Sciences , 60 :1165 , 1997 |
| PubMedID: |
| Title : Poster: The tetrahydropyridine ring confers optimal M-1 selectivity and blood brain barrier penetration among hexyloxy-1,2,5-thiadiazole azacycles - |
| Author(s) : Ward JS , Merritt L , Stratford R , Brown TJ , Wijayaratne R , Szewczyk SP , Calligaro DO , Bymaster FP , Shannon HE , Mitch CH , Johnson DW , Wikel JH , Olesen PH , Sheardown MJ , Swedberg MD , Sauerberg P |
| Ref : Life Sciences , 60 :1165 , 1997 |
| PubMedID: |
| Title : Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome - Mitch_1997_J.Med.Chem_40_538 |
| Author(s) : Mitch CH , Brown TJ , Bymaster FP , Calligaro DO , Dieckman D , Merrit L , Peters SC , Quimby SJ , Shannon HE , Shipley LA , Ward JS , Hansen K , Olesen PH , Sauerberg P , Sheardown MJ , Swedberg MD , Suzdak P , Greenwood B |
| Ref : Journal of Medicinal Chemistry , 40 :538 , 1997 |
| Abstract : |
| PubMedSearch : Mitch_1997_J.Med.Chem_40_538 |
| PubMedID: 9046345 |
| Title : Poster: Muscarinic receptor characterization and evaluation of a series of novel muscarinic ligands in the isolated rabbit thoracic aorta - |
| Author(s) : Sawyer BD , Shannon HE , Ward JS , Mitch CH , Sheardown MJ , Olesen PH , Sauerberg P |
| Ref : Life Sciences , 56(11-12) :1004 , 1995 |
| PubMedID: |
| Title : Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles - Ward_1995_J.Med.Chem_38_3469 |
| Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Sawyer BD , Mitch CH , Deeter JB , Peters SC , Sheardown MJ , Olesen PH , Swedberg MD , Sauerberg P |
| Ref : Journal of Medicinal Chemistry , 38 :3469 , 1995 |
| Abstract : |
| PubMedSearch : Ward_1995_J.Med.Chem_38_3469 |
| PubMedID: 7658434 |
| Title : The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells - Eckols_1995_Life.Sci_57_1183 |
| Author(s) : Eckols K , Bymaster FP , Mitch CH , Shannon HE , Ward JS , DeLapp NW |
| Ref : Life Sciences , 57 :1183 , 1995 |
| Abstract : |
| PubMedSearch : Eckols_1995_Life.Sci_57_1183 |
| PubMedID: 7674807 |
| Title : Poster: The M1 agonist xanomeline potently stimulates APPs release from CHO-m1 cells - |
| Author(s) : DeLapp NW , Eckols K , Bymaster FP , Mitch CH , Shannon HE , Ward JS |
| Ref : Life Sciences , 56(11-12) :1024 , 1995 |
| PubMedID: |
| Title : Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs - Sauerberg_1995_Life.Sci_56(11-12)_807 |
| Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Suzdak PD , Shannon HE , Bymaster FP , Calligaro DO , Mitch CH , Ward JS , Swedberg MD |
| Ref : Life Sciences , 56(11-12) :807 , 1995 |
| Abstract : |
| PubMedSearch : Sauerberg_1995_Life.Sci_56(11-12)_807 |
| PubMedID: 10188779 |
| Title : Poster: 3-(3-Hexyloxypyrazinyl)quinuclidine as a functionally selective M1 agonist - |
| Author(s) : Ward JS , Merritt L , Calligaro DO , Bymaster FP , Shannon HE , Sawyer BD , Mitch CH , Sheardown MJ , Olesen PH , Suzdak PD , Swedberg MD , Sauerberg P |
| Ref : Life Sciences , 56(11-12) :1003 , 1995 |
| PubMedID: |
| Title : Poster: Sidechain steric bulk and muscarinic agonist sar in alkoxy-TZTP's - |
| Author(s) : Mitch CH , Bymaster FP , Calligaro DO , Quimby SJ , Sawyer BD , Ward JS , Olesen PH , Sauerberg P , Sheardown MJ , Suzdak PD , Swedberg MD , Shannon HE |
| Ref : Life Sciences , 56(11-12) :1004 , 1995 |
| PubMedID: |
| Title : Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708\/NNC11-0232) - Bymaster_1994_J.Pharmacol.Exp.Ther_269_282 |
| Author(s) : Bymaster FP , Wong DT , Mitch CH , Ward JS , Calligaro DO , Schoepp DD , Shannon HE , Sheardown MJ , Olesen PH , Suzdak PD , Swedberg MD , Sauerberg P , et al. |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 269 :282 , 1994 |
| Abstract : |
| PubMedSearch : Bymaster_1994_J.Pharmacol.Exp.Ther_269_282 |
| PubMedID: 7909558 |
| Title : Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors - Shannon_1994_J.Pharmacol.Exp.Ther_269_271 |
| Author(s) : Shannon HE , Bymaster FP , Calligaro DO , Greenwood B , Mitch CH , Sawyer BD , Ward JS , Wong DT , Olesen PH , Sheardown MJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 269 :271 , 1994 |
| Abstract : |
| PubMedSearch : Shannon_1994_J.Pharmacol.Exp.Ther_269_271 |
| PubMedID: 7909557 |
| Title : Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens - Shannon_1993_Eur.J.Pharmacol_232_47 |
| Author(s) : Shannon HE , Sawyer BD , Bemis KG , Bymaster FP , Health I , Mitch CH , Ward JS |
| Ref : European Journal of Pharmacology , 232 :47 , 1993 |
| Abstract : |
| PubMedSearch : Shannon_1993_Eur.J.Pharmacol_232_47 |
| PubMedID: 8458395 |
| Title : Poster: Electronic requirements in a series of arecoline derivatives for muscarinic receptor-stimulated phosphoinositide metabolism in the rat brain - |
| Author(s) : Hoss WP , Ngur DO , Roknich S , Mitch CH , Quimby SJ , Ward JS , Merritt L , Sauerberg P , Messer WS, Jr. |
| Ref : Life Sciences , 52(5-6) :552 , 1993 |
| PubMedID: |
| Title : Poster: Hexyloxy-TZTP: A potent and selective M1 agonist in-vitro - |
| Author(s) : Mitch CH , Bymaster FP , Calligaro DO , Quimby SJ , Sawyer BD , Shannon HE , Ward JS , Olesen PH , Sauerberg P , Sheardown MJ , Suzdak PD |
| Ref : Life Sciences , 52(5-6) :550 , 1993 |
| PubMedID: |
| Title : Poster: Alkoxy sar around the functionally M1 selective agonist hexyloxy-TZTP - |
| Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Suzdak PD , Swedberg MD , Mitch CH , Ward JS , Calligaro DO , Sawyer BD , Bymaster FP , Shannon HE |
| Ref : Life Sciences , 52(5-6) :549 , 1993 |
| PubMedID: |
| Title : Poster: Muscarinic analgesia is mediated by non-M1 muscarinic receptors - |
| Author(s) : Swedberg MD , Sheardown MJ , Sauerberg P , Olesen PH , Suzdak PD , Shannon HE , Bymaster FP , Ward JS , Mitch CH , Calligaro DO |
| Ref : Life Sciences , 52(5-6) :594 , 1993 |
| PubMedID: |
| Title : Poster: Synthesis and structure-activity relationship of 3-(pyrazinyl)- 1, 2, 5, 6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M-1 pharmacophore - |
| Author(s) : Ward JS , Merritt L , Klimkowski VJ , Lamb ML , Mitch CH , Bymaster FP , Sawyer BD , Shannon HE , Olesen PH , Honore T , Sheardown MJ , Sauerberg P |
| Ref : Life Sciences , 52(5-6) :549 , 1993 |
| PubMedID: |
| Title : Poster: 3-hexyloxy analogs of TZTP are potent and selective M1 agonists in brain of rat in vivo - |
| Author(s) : Bymaster FP , Wong DT , Mitch CH , Ward JS , Calligaro DO , Shannon HE , Sawyer BD , Quimby SJ , Sheardown MJ , Olesen PH , Suzdak PD , Sauerberg P |
| Ref : Life Sciences , 52(5-6) :593 , 1993 |
| PubMedID: |
| Title : Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore - Ward_1992_J.Med.Chem_35_4011 |
| Author(s) : Ward JS , Merritt L , Klimkowski VJ , Lamb ML , Mitch CH , Bymaster FP , Sawyer BD , Shannon HE , Olesen PH , Honore T , Sheardown MJ , Sauerberg P |
| Ref : Journal of Medicinal Chemistry , 35 :4011 , 1992 |
| Abstract : |
| PubMedSearch : Ward_1992_J.Med.Chem_35_4011 |
| PubMedID: 1433209 |
| Title : Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres - Ngur_1992_Biochem.Biophys.Res.Commun_187_1389 |
| Author(s) : Ngur D , Roknich S , Mitch CH , Quimby SJ , Ward JS , Merritt L , Sauerberg P , Messer WS, Jr. , Hoss WP |
| Ref : Biochemical & Biophysical Research Communications , 187 :1389 , 1992 |
| Abstract : |
| PubMedSearch : Ngur_1992_Biochem.Biophys.Res.Commun_187_1389 |
| PubMedID: 1329735 |
| Title : Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats - Shannon_1990_J.Pharmacol.Exp.Ther_255_1071 |
| Author(s) : Shannon HE , Bemis KG , Hendrix JC , Ward JS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 255 :1071 , 1990 |
| Abstract : |
| PubMedSearch : Shannon_1990_J.Pharmacol.Exp.Ther_255_1071 |
| PubMedID: 2262893 |