| Title : Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase - Savini_2001_Bioorg.Med.Chem.Lett_11_1779 |
| Author(s) : Savini L , Campiani G , Gaeta A , Pellerano C , Fattorusso C , Chiasserini L , Fedorko JM , Saxena A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :1779 , 2001 |
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Abstract :
Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed. |
| PubMedSearch : Savini_2001_Bioorg.Med.Chem.Lett_11_1779 |
| PubMedID: 11425559 |
Savini L, Campiani G, Gaeta A, Pellerano C, Fattorusso C, Chiasserini L, Fedorko JM, Saxena A (2001)
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
Bioorganic & Medicinal Chemistry Lett
11 :1779
Savini L, Campiani G, Gaeta A, Pellerano C, Fattorusso C, Chiasserini L, Fedorko JM, Saxena A (2001)
Bioorganic & Medicinal Chemistry Lett
11 :1779