| Title : Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects - Aebi_2024_Chimia.(Aarau)_78_499 |
| Author(s) : Aebi J , Atz K , Ametamey SM , Benz J , Blaising J , Butini S , Campiani G , Carreira EM , Collin L , De Lago E , Gazzi T , Gertsch J , Gobbi L , Guba W , Fernandez-Ruiz J , Fingerle J , Haider A , He Y , Heitman LH , Honer M , Hunziker D , Kuhn B , Maccarrone M , Marki HP , Martin RE , Mohr P , Mu L , Nazare M , Nippa DF , Oddi S , O'Hara F , Pacher P , Romero J , Rover S , Rufer AC , Schibli R , Schneider G , Stepan AF , Sykes DA , Ullmer C , van der Stelt M , Veprintsev DB , Wittwer MB , Grether U |
| Ref : Chimia (Aarau) , 78 :499 , 2024 |
| Abstract : |
| PubMedSearch : Aebi_2024_Chimia.(Aarau)_78_499 |
| PubMedID: 39221845 |
| Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
| Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Butini_2024_J.Med.Chem__ |
| PubMedID: 38241614 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions - Papa_2022_Eur.J.Med.Chem_246_114952 |
| Author(s) : Papa A , Pasquini S , Galvani F , Cammarota M , Contri C , Carullo G , Gemma S , Ramunno A , Lamponi S , Gorelli B , Saponara S , Varani K , Mor M , Campiani G , Boscia F , Vincenzi F , Lodola A , Butini S |
| Ref : Eur Journal of Medicinal Chemistry , 246 :114952 , 2022 |
| Abstract : |
| PubMedSearch : Papa_2022_Eur.J.Med.Chem_246_114952 |
| PubMedID: 36462439 |
| Title : Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors - Janssen_2018_ACS.Chem.Biol_13_2406 |
| Author(s) : Janssen APA , van der Vliet D , Bakker AT , Jiang M , Grimm SH , Campiani G , Butini S , van der Stelt M |
| Ref : ACS Chemical Biology , 13 :2406 , 2018 |
| Abstract : |
| PubMedSearch : Janssen_2018_ACS.Chem.Biol_13_2406 |
| PubMedID: 30199617 |
| Title : Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease - Ismaili_2017_Prog.Neurobiol_151_4 |
| Author(s) : Ismaili L , Refouvelet B , Benchekroun M , Brogi S , Brindisi M , Gemma S , Campiani G , Filipic S , Agbaba D , Esteban G , Unzeta M , Nikolic K , Butini S , Marco-Contelles J |
| Ref : Prog Neurobiol , 151 :4 , 2017 |
| Abstract : |
| PubMedSearch : Ismaili_2017_Prog.Neurobiol_151_4 |
| PubMedID: 26797191 |
| Title : Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain - Brindisi_2016_J.Med.Chem_59_2612 |
| Author(s) : Brindisi M , Maramai S , Gemma S , Brogi S , Grillo A , Di Cesare Mannelli L , Gabellieri E , Lamponi S , Saponara S , Gorelli B , Tedesco D , Bonfiglio T , Landry C , Jung KM , Armirotti A , Luongo L , Ligresti A , Piscitelli F , Bertucci C , Dehouck MP , Campiani G , Maione S , Ghelardini C , Pittaluga A , Piomelli D , Di Marzo V , Butini S |
| Ref : Journal of Medicinal Chemistry , 59 :2612 , 2016 |
| Abstract : |
| PubMedSearch : Brindisi_2016_J.Med.Chem_59_2612 |
| PubMedID: 26888301 |
| Title : Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation - Wu_2016_Eur.J.Med.Chem_121_864 |
| Author(s) : Wu MY , Esteban G , Brogi S , Shionoya M , Wang L , Campiani G , Unzeta M , Inokuchi T , Butini S , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 121 :864 , 2016 |
| Abstract : |
| PubMedSearch : Wu_2016_Eur.J.Med.Chem_121_864 |
| PubMedID: 26471320 |
| Title : Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats - Lim_2016_Neuropsychopharmacology_41_1329 |
| Author(s) : Lim J , Igarashi M , Jung KM , Butini S , Campiani G , Piomelli D |
| Ref : Neuropsychopharmacology , 41 :1329 , 2016 |
| Abstract : |
| PubMedSearch : Lim_2016_Neuropsychopharmacology_41_1329 |
| PubMedID: 26361059 |
| Title : Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with beta-Amyloid Aggregation - Brogi_2014_CNS.Neurosci.Ther_20_624 |
| Author(s) : Brogi S , Butini S , Maramai S , Colombo R , Verga L , Lanni C , De Lorenzi E , Lamponi S , Andreassi M , Bartolini M , Andrisano V , Novellino E , Campiani G , Brindisi M , Gemma S |
| Ref : CNS Neurosci Ther , 20 :624 , 2014 |
| Abstract : |
| PubMedSearch : Brogi_2014_CNS.Neurosci.Ther_20_624 |
| PubMedID: 24935788 |
| Title : Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation - Butini_2013_ACS.Med.Chem.Lett_4_1178 |
| Author(s) : Butini S , Brindisi M , Brogi S , Maramai S , Guarino E , Panico A , Saxena A , Chauhan V , Colombo R , Verga L , De Lorenzi E , Bartolini M , Andrisano V , Novellino E , Campiani G , Gemma S |
| Ref : ACS Med Chem Lett , 4 :1178 , 2013 |
| Abstract : |
| PubMedSearch : Butini_2013_ACS.Med.Chem.Lett_4_1178 |
| PubMedID: 24900626 |
| Title : Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors - Butini_2008_J.Med.Chem_51_3154 |
| Author(s) : Butini S , Campiani G , Borriello M , Gemma S , Panico A , Persico M , Catalanotti B , Ros S , Brindisi M , Agnusdei M , Fiorini I , Nacci V , Novellino E , Belinskaya T , Saxena A , Fattorusso C |
| Ref : Journal of Medicinal Chemistry , 51 :3154 , 2008 |
| Abstract : |
| PubMedSearch : Butini_2008_J.Med.Chem_51_3154 |
| PubMedID: 18479118 |
| Title : Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity - Butini_2008_Bioorg.Med.Chem.Lett_18_5213 |
| Author(s) : Butini S , Guarino E , Campiani G , Brindisi M , Coccone SS , Fiorini I , Novellino E , Belinskaya T , Saxena A , Gemma S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5213 , 2008 |
| Abstract : |
| PubMedSearch : Butini_2008_Bioorg.Med.Chem.Lett_18_5213 |
| PubMedID: 18786825 |
| Title : Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor - Colletier_2006_J.Am.Chem.Soc_128_4526 |
| Author(s) : Colletier JP , Sanson B , Nachon F , Gabellieri E , Fattorusso C , Campiani G , Weik M |
| Ref : Journal of the American Chemical Society , 128 :4526 , 2006 |
| Abstract : |
| PubMedSearch : Colletier_2006_J.Am.Chem.Soc_128_4526 |
| PubMedID: 16594661 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites - Gemma_2006_J.Med.Chem_49_3421 |
| Author(s) : Gemma S , Gabellieri E , Huleatt P , Fattorusso C , Borriello M , Catalanotti B , Butini S , De Angelis M , Novellino E , Nacci V , Belinskaya T , Saxena A , Campiani G |
| Ref : Journal of Medicinal Chemistry , 49 :3421 , 2006 |
| Abstract : |
| PubMedSearch : Gemma_2006_J.Med.Chem_49_3421 |
| PubMedID: 16722663 |
| Title : Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors - Campiani_2005_J.Med.Chem_48_1919 |
| Author(s) : Campiani G , Fattorusso C , Butini S , Gaeta A , Agnusdei M , Gemma S , Persico M , Catalanotti B , Savini L , Nacci V , Novellino E , Holloway HW , Greig NH , Belinskaya T , Fedorko JM , Saxena A |
| Ref : Journal of Medicinal Chemistry , 48 :1919 , 2005 |
| Abstract : |
| PubMedSearch : Campiani_2005_J.Med.Chem_48_1919 |
| PubMedID: 15771436 |
| Title : Poster (99) Rational design, synthesis and pharmacological evaluation of novel, selective and highly potent cholinesterase inhibitors - |
| Author(s) : Gaeta A , Savini L , Fattorusso C , Catalanotti B , Campiani G , Chiasserini L , Pellerano C , McKissic D , Saxena A |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :372 , 2004 |
| PubMedID: |
| Title : Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors - Savini_2003_J.Med.Chem_46_1 |
| Author(s) : Savini L , Gaeta A , Fattorusso C , Catalanotti B , Campiani G , Chiasserini L , Pellerano C , Novellino E , McKissic D , Saxena A |
| Ref : Journal of Medicinal Chemistry , 46 :1 , 2003 |
| Abstract : |
| PubMedSearch : Savini_2003_J.Med.Chem_46_1 |
| PubMedID: 12502352 |
| Title : Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase - Savini_2001_Bioorg.Med.Chem.Lett_11_1779 |
| Author(s) : Savini L , Campiani G , Gaeta A , Pellerano C , Fattorusso C , Chiasserini L , Fedorko JM , Saxena A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :1779 , 2001 |
| Abstract : |
| PubMedSearch : Savini_2001_Bioorg.Med.Chem.Lett_11_1779 |
| PubMedID: 11425559 |
| Title : Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring - Campiani_1998_Bioorg.Med.Chem.Lett_8_1413 |
| Author(s) : Campiani G , Kozikowski AP , Wang S , Ming L , Nacci V , Saxena A , Doctor BP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1413 , 1998 |
| Abstract : |
| PubMedSearch : Campiani_1998_Bioorg.Med.Chem.Lett_8_1413 |
| PubMedID: 9871776 |