Saxena A

General

Full name : Saxena Ashima

First name : Ashima

Mail : Division of Bacterial & Rickettsial Diseases\; Walter Reed Army Institute of Research\; 503 Robert Grant Ave.\; Silver Spring\; MD 20910-7500

Zip Code :

City :

Country : USA

Email : ashima.saxena.civ@mail.mil

Phone : +13013199406

Fax : 202-782-6304

Website :

Directory :

Comment

References (100)

Title : Low levels of endogenous cholinesterases support the choice of cows, sheep and goats for the transgenic expression of human butyrylcholinesterase in milk - Belinskaya_2023_Chem.Biol.Interact_14ChEPon_110691
Author(s) : Belinskaya T , Saxena A
Ref : Chemico-Biological Interactions , :110691 , 2023
Abstract :
PubMedSearch : Belinskaya_2023_Chem.Biol.Interact_14ChEPon_110691
PubMedID: 37659623

Title : Conjugates of Human Serum Butyrylcholinesterase and Nerve Agents are Behaviorally Safe in Rhesus Macaques - Saxena_2021_Chem.Biol.Interact__109499
Author(s) : Saxena A , Myers TM , Sipos ML
Ref : Chemico-Biological Interactions , :109499 , 2021
Abstract :
PubMedSearch : Saxena_2021_Chem.Biol.Interact__109499
PubMedID: 33961835

Title : Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species - Naik_2020_Chem.Biol.Interact__109225
Author(s) : Naik RS , Belinskaya T , Vinayaka CR , Saxena A
Ref : Chemico-Biological Interactions , :109225 , 2020
Abstract :
PubMedSearch : Naik_2020_Chem.Biol.Interact__109225
PubMedID: 32795450

Title : Acetylcholinesterase inhibition resulting from exposure to inhaled OP can be prevented by pretreatment with BChE in both macaques and minipigs - Rosenberg_2020_Neuropharmacol__108150
Author(s) : Rosenberg YJ , Saxena A
Ref : Neuropharmacology , :108150 , 2020
Abstract :
PubMedSearch : Rosenberg_2020_Neuropharmacol__108150
PubMedID: 32442543

Title : Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM - diTargiani_2020_Chem.Biol.Interact__109092
Author(s) : diTargiani RC , Belinskaya T , Tipparaju P , Lockridge O , Saxena A
Ref : Chemico-Biological Interactions , :109092 , 2020
Abstract :
PubMedSearch : diTargiani_2020_Chem.Biol.Interact__109092
PubMedID: 32278739

Title : Characterization of butyrylcholinesterase from porcine milk - Saxena_2018_Arch.Biochem.Biophys_652_38
Author(s) : Saxena A , Belinskaya T , Schopfer LM , Lockridge O
Ref : Archives of Biochemistry & Biophysics , 652 :38 , 2018
Abstract :
PubMedSearch : Saxena_2018_Arch.Biochem.Biophys_652_38
PubMedID: 29908755
Gene_locus related to this paper: pig-BCHE

Title : Identification of Carboxylesterase, Butyrylcholinesterase, Acetylcholinesterase, Paraoxonase, and Albumin Pseudoesterase in Guinea Pig Plasma through Nondenaturing Gel Electrophoresis - Napon_2018_Comp.Med_68_367
Author(s) : Napon G , Dafferner AJ , Saxena A , Lockridge O
Ref : Comp Med , 68 :367 , 2018
Abstract :
PubMedSearch : Napon_2018_Comp.Med_68_367
PubMedID: 30278860

Title : Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa) - Saxena_2018_Data.Brief_20_1607
Author(s) : Saxena A , Belinskaya T , Schopfer LM , Lockridge O
Ref : Data Brief , 20 :1607 , 2018
Abstract :
PubMedSearch : Saxena_2018_Data.Brief_20_1607
PubMedID: 30263913

Title : IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis - Schaffert_2015_Eur.J.Immunol_45_1339
Author(s) : Schaffert H , Pelz A , Saxena A , Losen M , Meisel A , Thiel A , Kohler S
Ref : European Journal of Immunology , 45 :1339 , 2015
Abstract :
PubMedSearch : Schaffert_2015_Eur.J.Immunol_45_1339
PubMedID: 25676041

Title : Prophylaxis with human serum butyrylcholinesterase protects Gottingen minipigs exposed to a lethal high-dose of sarin vapor - Saxena_2015_Chem.Biol.Interact_238_161
Author(s) : Saxena A , Hastings NB , Sun W , Dabisch PA , Hulet SW , Jakubowski EM , Mioduszewski RJ , Doctor BP
Ref : Chemico-Biological Interactions , 238 :161 , 2015
Abstract :
PubMedSearch : Saxena_2015_Chem.Biol.Interact_238_161
PubMedID: 26145887

Title : Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase - Chambers_2015_Toxicol.In.Vitro_29_408
Author(s) : Chambers C , Luo C , Tong M , Yang Y , Saxena A
Ref : Toxicol In Vitro , 29 :408 , 2015
Abstract :
PubMedSearch : Chambers_2015_Toxicol.In.Vitro_29_408
PubMedID: 25451328

Title : Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice - Sun_2013_Chem.Biol.Interact_203_172
Author(s) : Sun W , Luo C , Tipparaju P , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 203 :172 , 2013
Abstract :
PubMedSearch : Sun_2013_Chem.Biol.Interact_203_172
PubMedID: 23220586

Title : Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals - Naik_2013_J.Appl.Toxicol_33_290
Author(s) : Naik RS , Liu W , Saxena A
Ref : Journal of Applied Toxicology , 33 :290 , 2013
Abstract :
PubMedSearch : Naik_2013_J.Appl.Toxicol_33_290
PubMedID: 22407886

Title : In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase - Chandrasekaran_2013_Toxicol.In.Vitro_27_499
Author(s) : Chandrasekaran L , Belinskaya T , Saxena A
Ref : Toxicol In Vitro , 27 :499 , 2013
Abstract :
PubMedSearch : Chandrasekaran_2013_Toxicol.In.Vitro_27_499
PubMedID: 22677456

Title : Draft Genome Sequence of Agrobacterium sp. Strain UHFBA-218, Isolated from Rhizosphere Soil of Crown Gall-Infected Cherry Rootstock Colt - Dua_2013_Genome.Announc_1_E00302
Author(s) : Dua A , Sangwan N , Kaur J , Saxena A , Kohli P , Gupta AK , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract :
PubMedSearch : Dua_2013_Genome.Announc_1_E00302
PubMedID: 23723402
Gene_locus related to this paper: rhird-m8b858 , rhird-m8b836 , rhird-a0a067u386 , rhird-m8b397

Title : Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase - Biberoglu_2013_Biochim.Biophys.Acta_1834_745
Author(s) : Biberoglu K , Schopfer LM , Saxena A , Tacal O , Lockridge O
Ref : Biochimica & Biophysica Acta , 1834 :745 , 2013
Abstract :
PubMedSearch : Biberoglu_2013_Biochim.Biophys.Acta_1834_745
PubMedID: 23352838

Title : Genome Sequence of Novosphingobium lindaniclasticum LE124T, Isolated from a Hexachlorocyclohexane Dumpsite - Saxena_2013_Genome.Announc_1_e00715
Author(s) : Saxena A , Nayyar N , Sangwan N , Kumari R , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract :
PubMedSearch : Saxena_2013_Genome.Announc_1_e00715
PubMedID: 24029761
Gene_locus related to this paper: 9sphn-t0hqb1 , 9sphn-t0hmn5 , 9sphn-t0iya6 , 9sphn-t0gy64 , 9sphn-t0hhu1 , 9sphn-t0i5p8 , 9sphn-t0hp61

Title : Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide - Naik_2013_Chem.Biol.Interact_203_24
Author(s) : Naik RS , Pattabiraman N , Patel KA , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 203 :24 , 2013
Abstract :
PubMedSearch : Naik_2013_Chem.Biol.Interact_203_24
PubMedID: 23044488

Title : Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation - Butini_2013_ACS.Med.Chem.Lett_4_1178
Author(s) : Butini S , Brindisi M , Brogi S , Maramai S , Guarino E , Panico A , Saxena A , Chauhan V , Colombo R , Verga L , De Lorenzi E , Bartolini M , Andrisano V , Novellino E , Campiani G , Gemma S
Ref : ACS Med Chem Lett , 4 :1178 , 2013
Abstract :
PubMedSearch : Butini_2013_ACS.Med.Chem.Lett_4_1178
PubMedID: 24900626

Title : Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase - Belinskaya_2012_Biochim.Biophys.Acta_1824_701
Author(s) : Belinskaya T , Pattabiraman N , diTargiani RC , Choi M , Saxena A
Ref : Biochimica & Biophysica Acta , 1824 :701 , 2012
Abstract :
PubMedSearch : Belinskaya_2012_Biochim.Biophys.Acta_1824_701
PubMedID: 22401958

Title : Characterization of human serum butyrylcholinesterase in rhesus monkeys: behavioral and physiological effects - Myers_2012_Neurotoxicol.Teratol_34_323
Author(s) : Myers TM , Sun W , Naik RS , Clark MG , Doctor BP , Saxena A
Ref : Neurotoxicology & Teratology , 34 :323 , 2012
Abstract :
PubMedSearch : Myers_2012_Neurotoxicol.Teratol_34_323
PubMedID: 22402122

Title : Genome sequence of Acinetobacter sp. strain HA, isolated from the gut of the polyphagous insect pest Helicoverpa armigera - Malhotra_2012_J.Bacteriol_194_5156
Author(s) : Malhotra J , Dua A , Saxena A , Sangwan N , Mukherjee U , Pandey N , Rajagopal R , Khurana P , Khurana JP , Lal R
Ref : Journal of Bacteriology , 194 :5156 , 2012
Abstract :
PubMedSearch : Malhotra_2012_J.Bacteriol_194_5156
PubMedID: 22933775
Gene_locus related to this paper: 9gamm-i4zrl8 , 9gamm-i4zpd5

Title : Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX - Saxena_2011_Biochem.Pharmacol_81_164
Author(s) : Saxena A , Sun W , Fedorko JM , Koplovitz I , Doctor BP
Ref : Biochemical Pharmacology , 81 :164 , 2011
Abstract :
PubMedSearch : Saxena_2011_Biochem.Pharmacol_81_164
PubMedID: 20846507

Title : Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699 - Verma_2011_J.Bacteriol_193_5562
Author(s) : Verma M , Kaur J , Kumar M , Kumari K , Saxena A , Anand S , Nigam A , Ravi V , Raghuvanshi S , Khurana P , Tyagi AK , Khurana JP , Lal R
Ref : Journal of Bacteriology , 193 :5562 , 2011
Abstract :
PubMedSearch : Verma_2011_J.Bacteriol_193_5562
PubMedID: 21914879
Gene_locus related to this paper: amymu-d8hka5 , amymu-d8hpp2 , amymu-d8hu68 , amymu-d8hy73 , amymu-d8i2j5 , amymu-d8i8i8 , amyms-g0fkj6 , amyms-g0g7f0 , amyms-g0fps5

Title : Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Gottingen minipigs exposed to sarin vapor - Saxena_2011_Biochem.Pharmacol_82_1984
Author(s) : Saxena A , Sun W , Dabisch PA , Hulet SW , Hastings NB , Jakubowski EM , Mioduszewski RJ , Doctor BP
Ref : Biochemical Pharmacology , 82 :1984 , 2011
Abstract :
PubMedSearch : Saxena_2011_Biochem.Pharmacol_82_1984
PubMedID: 21968035

Title : Mechanism for potent reactivation ability of H oximes analyzed by reactivation kinetic studies with cholinesterases from different species - Luo_2010_Chem.Biol.Interact_187_185
Author(s) : Luo C , Chambers C , Yang Y , Saxena A
Ref : Chemico-Biological Interactions , 187 :185 , 2010
Abstract :
PubMedSearch : Luo_2010_Chem.Biol.Interact_187_185
PubMedID: 20096273

Title : Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes - Luo_2010_Biochem.Pharmacol_80_1427
Author(s) : Luo C , Chambers C , Pattabiraman N , Tong M , Tipparaju P , Saxena A
Ref : Biochemical Pharmacology , 80 :1427 , 2010
Abstract :
PubMedSearch : Luo_2010_Biochem.Pharmacol_80_1427
PubMedID: 20655881

Title : Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model - Rosenberg_2010_Chem.Biol.Interact_187_279
Author(s) : Rosenberg YJ , Saxena A , Sun W , Jiang X , Chilukuri N , Luo C , Doctor BP , Lee KD
Ref : Chemico-Biological Interactions , 187 :279 , 2010
Abstract :
PubMedSearch : Rosenberg_2010_Chem.Biol.Interact_187_279
PubMedID: 20211615

Title : Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects - Myers_2010_Pharmacol.Biochem.Behav_94_477
Author(s) : Myers TM , Sun W , Saxena A , Doctor BP , Bonvillain AJ , Clark MG
Ref : Pharmacol Biochem Behav , 94 :477 , 2010
Abstract :
PubMedSearch : Myers_2010_Pharmacol.Biochem.Behav_94_477
PubMedID: 19909771

Title : In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity - diTargiani_2010_Chem.Biol.Interact_187_349
Author(s) : diTargiani RC , Chandrasekaran L , Belinskaya T , Saxena A
Ref : Chemico-Biological Interactions , 187 :349 , 2010
Abstract :
PubMedSearch : diTargiani_2010_Chem.Biol.Interact_187_349
PubMedID: 20176006

Title : Safety of administration of human butyrylcholinesterase and its conjugates with soman or VX in rats - Genovese_2010_Basic.Clin.Pharmacol.Toxicol_106_428
Author(s) : Genovese RF , Sun W , Johnson CC , diTargiani RC , Doctor BP , Saxena A
Ref : Basic Clin Pharmacol Toxicol , 106 :428 , 2010
Abstract :
PubMedSearch : Genovese_2010_Basic.Clin.Pharmacol.Toxicol_106_428
PubMedID: 20050840

Title : Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate - Gabel_2009_Biophys.J_96_1489
Author(s) : Gabel F , Masson P , Froment MT , Doctor BP , Saxena A , Silman I , Zaccai G , Weik M
Ref : Biophysical Journal , 96 :1489 , 2009
Abstract :
PubMedSearch : Gabel_2009_Biophys.J_96_1489
PubMedID: 19217865

Title : Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents - Chilukuri_2009_Mol.Pharmacol_76_612
Author(s) : Chilukuri N , Duysen EG , Parikh K , diTargiani RC , Doctor BP , Lockridge O , Saxena A
Ref : Molecular Pharmacology , 76 :612 , 2009
Abstract :
PubMedSearch : Chilukuri_2009_Mol.Pharmacol_76_612
PubMedID: 19542320

Title : Pharmacokinetics and immunologic consequences of repeated administrations of purified heterologous and homologous butyrylcholinesterase in mice - Sun_2009_Life.Sci_85_657
Author(s) : Sun W , Luo C , Naik RS , Doctor BP , Saxena A
Ref : Life Sciences , 85 :657 , 2009
Abstract :
PubMedSearch : Sun_2009_Life.Sci_85_657
PubMedID: 19772863

Title : Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors - Butini_2008_J.Med.Chem_51_3154
Author(s) : Butini S , Campiani G , Borriello M , Gemma S , Panico A , Persico M , Catalanotti B , Ros S , Brindisi M , Agnusdei M , Fiorini I , Nacci V , Novellino E , Belinskaya T , Saxena A , Fattorusso C
Ref : Journal of Medicinal Chemistry , 51 :3154 , 2008
Abstract :
PubMedSearch : Butini_2008_J.Med.Chem_51_3154
PubMedID: 18479118

Title : Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity - Butini_2008_Bioorg.Med.Chem.Lett_18_5213
Author(s) : Butini S , Guarino E , Campiani G , Brindisi M , Coccone SS , Fiorini I , Novellino E , Belinskaya T , Saxena A , Gemma S
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5213 , 2008
Abstract :
PubMedSearch : Butini_2008_Bioorg.Med.Chem.Lett_18_5213
PubMedID: 18786825

Title : Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases - Luo_2008_Chem.Biol.Interact_175_261
Author(s) : Luo C , Tong M , Maxwell DM , Saxena A
Ref : Chemico-Biological Interactions , 175 :261 , 2008
Abstract :
PubMedSearch : Luo_2008_Chem.Biol.Interact_175_261
PubMedID: 18555982

Title : Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys - Sun_2008_Chem.Biol.Interact_175_428
Author(s) : Sun W , Doctor BP , Lenz DE , Saxena A
Ref : Chemico-Biological Interactions , 175 :428 , 2008
Abstract :
PubMedSearch : Sun_2008_Chem.Biol.Interact_175_428
PubMedID: 18674756

Title : Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo - Chilukuri_2008_Chem.Biol.Interact_175_327
Author(s) : Chilukuri N , Duysen EG , Parikh K , Sun W , Doctor BP , Lockridge O , Saxena A
Ref : Chemico-Biological Interactions , 175 :327 , 2008
Abstract :
PubMedSearch : Chilukuri_2008_Chem.Biol.Interact_175_327
PubMedID: 18499092

Title : Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase - Chilukuri_2008_Chem.Biol.Interact_175_255
Author(s) : Chilukuri N , Sun W , Naik RS , Parikh K , Tang L , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 175 :255 , 2008
Abstract :
PubMedSearch : Chilukuri_2008_Chem.Biol.Interact_175_255
PubMedID: 18603232

Title : Comparison of methods used for the determination of cholinesterase activity in whole blood - Naik_2008_Chem.Biol.Interact_175_298
Author(s) : Naik RS , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 175 :298 , 2008
Abstract :
PubMedSearch : Naik_2008_Chem.Biol.Interact_175_298
PubMedID: 18555980

Title : Efficacy of human serum butyrylcholinesterase against sarin vapor - Saxena_2008_Chem.Biol.Interact_175_267
Author(s) : Saxena A , Sun W , Dabisch PA , Hulet SW , Hastings NB , Jakubowski EM , Mioduszewski RJ , Doctor BP
Ref : Chemico-Biological Interactions , 175 :267 , 2008
Abstract :
PubMedSearch : Saxena_2008_Chem.Biol.Interact_175_267
PubMedID: 18597747

Title : A repeated injection of polyethyleneglycol-conjugated recombinant human butyrylcholinesterase elicits immune response in mice - Chilukuri_2008_Toxicol.Appl.Pharmacol_231_423
Author(s) : Chilukuri N , Sun W , Parikh K , Naik RS , Tang L , Doctor BP , Saxena A
Ref : Toxicol Appl Pharmacol , 231 :423 , 2008
Abstract :
PubMedSearch : Chilukuri_2008_Toxicol.Appl.Pharmacol_231_423
PubMedID: 18586293

Title : Developing procedures for the large-scale purification of human serum butyrylcholinesterase - Saxena_2008_Protein.Expr.Purif_61_191
Author(s) : Saxena A , Luo C , Doctor BP
Ref : Protein Expr Purif , 61 :191 , 2008
Abstract :
PubMedSearch : Saxena_2008_Protein.Expr.Purif_61_191
PubMedID: 18602477

Title : An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes - Luo_2007_Biochemistry_46_11771
Author(s) : Luo C , Tong M , Chilukuri N , Brecht K , Maxwell DM , Saxena A
Ref : Biochemistry , 46 :11771 , 2007
Abstract :
PubMedSearch : Luo_2007_Biochemistry_46_11771
PubMedID: 17900152

Title : Evaluation of cognitive and biochemical effects of low-level exposure to sarin in rhesus and African green monkeys - Genovese_2007_Toxicology_231_11
Author(s) : Genovese RF , Oubre JL , Jakubowski EM , Fleming PJ , Saxena A , Rockwood GA , Tipparaju P , Willmore CB
Ref : Toxicology , 231 :11 , 2007
Abstract :
PubMedSearch : Genovese_2007_Toxicology_231_11
PubMedID: 17126468

Title : Bioscavenger for protection from toxicity of organophosphorus compounds - Saxena_2006_J.Mol.Neurosci_30_145
Author(s) : Saxena A , Sun W , Luo C , Myers TM , Koplovitz I , Lenz DE , Doctor BP
Ref : Journal of Molecular Neuroscience , 30 :145 , 2006
Abstract :
PubMedSearch : Saxena_2006_J.Mol.Neurosci_30_145
PubMedID: 17192662

Title : Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites - Gemma_2006_J.Med.Chem_49_3421
Author(s) : Gemma S , Gabellieri E , Huleatt P , Fattorusso C , Borriello M , Catalanotti B , Butini S , De Angelis M , Novellino E , Nacci V , Belinskaya T , Saxena A , Campiani G
Ref : Journal of Medicinal Chemistry , 49 :3421 , 2006
Abstract :
PubMedSearch : Gemma_2006_J.Med.Chem_49_3421
PubMedID: 16722663

Title : Safety and pharmacokinetics of human serum butyrylcholinesterase in guinea pigs - Sun_2005_Chem.Biol.Interact_157-158_428
Author(s) : Sun W , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 157-158 :428 , 2005
Abstract :
PubMedSearch : Sun_2005_Chem.Biol.Interact_157-158_428
PubMedID: 16429577

Title : Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase - Chilukuri_2005_Chem.Biol.Interact_157-158_115
Author(s) : Chilukuri N , Parikh K , Sun W , Naik R , Tipparaju P , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 157-158 :115 , 2005
Abstract :
PubMedSearch : Chilukuri_2005_Chem.Biol.Interact_157-158_115
PubMedID: 16253215

Title : Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL\/6J mice - Clark_2005_Pharmacol.Biochem.Behav_81_497
Author(s) : Clark MG , Sun W , Myers TM , Bansal R , Doctor BP , Saxena A
Ref : Pharmacol Biochem Behav , 81 :497 , 2005
Abstract :
PubMedSearch : Clark_2005_Pharmacol.Biochem.Behav_81_497
PubMedID: 15913750

Title : In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger - Cerasoli_2005_Chem.Biol.Interact_157-158_363
Author(s) : Cerasoli DM , Griffiths EM , Doctor BP , Saxena A , Fedorko JM , Greig NH , Yu QS , Huang Y , Wilgus H , Karatzas CN , Koplovitz I , Lenz DE
Ref : Chemico-Biological Interactions , 157-158 :363 , 2005
Abstract :
PubMedSearch : Cerasoli_2005_Chem.Biol.Interact_157-158_363
PubMedID: 16429486

Title : An ex vivo approach for the evaluation of reversible inhibitors as potential pretreatments against organophosphate toxicity - Tonduli_2005_Chem.Biol.Interact_157-158_426
Author(s) : Tonduli LS , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 157-158 :426 , 2005
Abstract :
PubMedSearch : Tonduli_2005_Chem.Biol.Interact_157-158_426
PubMedID: 16429574

Title : Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys - Lenz_2005_Chem.Biol.Interact_157-158_205
Author(s) : Lenz DE , Maxwell DM , Koplovitz I , Clark CR , Capacio BR , Cerasoli DM , Federko JM , Luo C , Saxena A , Doctor BP , Olson C
Ref : Chemico-Biological Interactions , 157-158 :205 , 2005
Abstract :
PubMedSearch : Lenz_2005_Chem.Biol.Interact_157-158_205
PubMedID: 16289064

Title : Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases -
Author(s) : Luo C , Dawson M , Chambers C , Chilukuri N , Radic Z , Taylor P , Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 157-158 :393 , 2005
PubMedID: 16429528

Title : Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study - Gabel_2005_Biophys.J_89_3303
Author(s) : Gabel F , Weik M , Masson P , Renault F , Fournier D , Brochier L , Doctor BP , Saxena A , Silman I , Zaccai G
Ref : Biophysical Journal , 89 :3303 , 2005
Abstract :
PubMedSearch : Gabel_2005_Biophys.J_89_3303
PubMedID: 16100272

Title : Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice - Saxena_2005_Chem.Biol.Interact_157-158_199
Author(s) : Saxena A , Sun W , Luo C , Doctor BP
Ref : Chemico-Biological Interactions , 157-158 :199 , 2005
Abstract :
PubMedSearch : Saxena_2005_Chem.Biol.Interact_157-158_199
PubMedID: 16263104

Title : Bioscavengers for the protection of humans against organophosphate toxicity - Doctor_2005_Chem.Biol.Interact_157-158_167
Author(s) : Doctor BP , Saxena A
Ref : Chemico-Biological Interactions , 157-158 :167 , 2005
Abstract :
PubMedSearch : Doctor_2005_Chem.Biol.Interact_157-158_167
PubMedID: 16293236

Title : Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors - Campiani_2005_J.Med.Chem_48_1919
Author(s) : Campiani G , Fattorusso C , Butini S , Gaeta A , Agnusdei M , Gemma S , Persico M , Catalanotti B , Savini L , Nacci V , Novellino E , Holloway HW , Greig NH , Belinskaya T , Fedorko JM , Saxena A
Ref : Journal of Medicinal Chemistry , 48 :1919 , 2005
Abstract :
PubMedSearch : Campiani_2005_J.Med.Chem_48_1919
PubMedID: 15771436

Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase. -
Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A
Ref : Cholinergic Mechanisms, CRC Press :627 , 2004
PubMedID:

Title : The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study - Gabel_2004_Biophys.J_86_3152
Author(s) : Gabel F , Weik M , Doctor BP , Saxena A , Fournier D , Brochier L , Renault F , Masson P , Silman I , Zaccai G
Ref : Biophysical Journal , 86 :3152 , 2004
Abstract :
PubMedSearch : Gabel_2004_Biophys.J_86_3152
PubMedID: 15111428

Title : Poster (99) Rational design, synthesis and pharmacological evaluation of novel, selective and highly potent cholinesterase inhibitors -
Author(s) : Gaeta A , Savini L , Fattorusso C , Catalanotti B , Campiani G , Chiasserini L , Pellerano C , McKissic D , Saxena A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :372 , 2004
PubMedID:

Title : Strategy for reactivation of organophosphate-inhibited human butyrylcholinesterase -
Author(s) : Luo C , Dawson M , Maxwell DM , Doctor BP , Saxena A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :251 , 2004
PubMedID:

Title : Human serum butyrylcholinesterase: A future generation antidote for organophosphate chemical warfare agent toxicity . -
Author(s) : Saxena A , Luo C , Bansal R , Sun W , Clark M , Ashani Y , Ross M , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :269 , 2004
PubMedID:

Title : Poster (32) Bioscavengers: antidotes for organophosphate chemical warfare agent toxicity. -
Author(s) : Doctor BP , Saxena A , Ashani Y , Ross M
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :337 , 2004
PubMedID:

Title : Poster (33) Strategy for the reactivation of organophosphate-inhibited human butyrylcholinesterase -
Author(s) : Luo C , McKissic D , Doctor BP , Saxena A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :338 , 2004
PubMedID:

Title : Poster (36) Human serum butyrylcholinesterase: a future generation antidote for organophosphate chemical warfare agent toxicity -
Author(s) : Saxena A , Luo C , Bansal R , Sun W , Clark M , Ashani Y , Ross M , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :339 , 2004
PubMedID:

Title : Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities - Sevelova_2004_Inhal.Toxicol_16_531
Author(s) : Sevelova L , Bajgar J , Saxena A , Doctor BP
Ref : Inhal Toxicol , 16 :531 , 2004
Abstract :
PubMedSearch : Sevelova_2004_Inhal.Toxicol_16_531
PubMedID: 15204744

Title : Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain - Saxena_2003_Biochemistry_42_15292
Author(s) : Saxena A , Hur RS , Luo C , Doctor BP
Ref : Biochemistry , 42 :15292 , 2003
Abstract :
PubMedSearch : Saxena_2003_Biochemistry_42_15292
PubMedID: 14690439

Title : Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors - Savini_2003_J.Med.Chem_46_1
Author(s) : Savini L , Gaeta A , Fattorusso C , Catalanotti B , Campiani G , Chiasserini L , Pellerano C , Novellino E , McKissic D , Saxena A
Ref : Journal of Medicinal Chemistry , 46 :1 , 2003
Abstract :
PubMedSearch : Savini_2003_J.Med.Chem_46_1
PubMedID: 12502352

Title : Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators - Ashani_2003_Biochem.Pharmacol_66_191
Author(s) : Ashani Y , Bhattacharjee AK , Leader H , Saxena A , Doctor BP
Ref : Biochemical Pharmacology , 66 :191 , 2003
Abstract :
PubMedSearch : Ashani_2003_Biochem.Pharmacol_66_191
PubMedID: 12826262

Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase - Luo_2003_Biochem.Pharmacol_66_387
Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A
Ref : Biochemical Pharmacology , 66 :387 , 2003
Abstract :
PubMedSearch : Luo_2003_Biochem.Pharmacol_66_387
PubMedID: 12907237

Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases - Saxena_2003_Eur.J.Biochem_270_4447
Author(s) : Saxena A , Fedorko JM , Vinayaka CR , Medhekar R , Radic Z , Taylor P , Lockridge O , Doctor BP
Ref : European Journal of Biochemistry , 270 :4447 , 2003
Abstract :
PubMedSearch : Saxena_2003_Eur.J.Biochem_270_4447
PubMedID: 14622273

Title : Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase - Rosenberg_2002_Life.Sci_72_125
Author(s) : Rosenberg YJ , Luo C , Ashani Y , Doctor BP , Fischer R , Wolfe G , Saxena A
Ref : Life Sciences , 72 :125 , 2002
Abstract :
PubMedSearch : Rosenberg_2002_Life.Sci_72_125
PubMedID: 12417246

Title : Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B - Rajendran_2002_Bioorg.Med.Chem.Lett_12_1521
Author(s) : Rajendran V , Saxena A , Doctor BP , Kozikowski AP
Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1521 , 2002
Abstract :
PubMedSearch : Rajendran_2002_Bioorg.Med.Chem.Lett_12_1521
PubMedID: 12031333

Title : Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase - Savini_2001_Bioorg.Med.Chem.Lett_11_1779
Author(s) : Savini L , Campiani G , Gaeta A , Pellerano C , Fattorusso C , Chiasserini L , Fedorko JM , Saxena A
Ref : Bioorganic & Medicinal Chemistry Lett , 11 :1779 , 2001
Abstract :
PubMedSearch : Savini_2001_Bioorg.Med.Chem.Lett_11_1779
PubMedID: 11425559

Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937
Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP
Ref : Biochemistry , 38 :9937 , 1999
Abstract :
PubMedSearch : Luo_1999_Biochemistry_38_9937
PubMedID: 10433700

Title : Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases - Maxwell_1999_Chem.Biol.Interact_119-120_419
Author(s) : Maxwell DM , Saxena A , Gordon RK , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :419 , 1999
Abstract :
PubMedSearch : Maxwell_1999_Chem.Biol.Interact_119-120_419
PubMedID: 10421479

Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129
Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :129 , 1999
Abstract :
PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129
PubMedID: 10421446

Title : Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase - Saxena_1999_Chem.Biol.Interact_119-120_61
Author(s) : Saxena A , Redman AM , Jiang X , Lockridge O , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :61 , 1999
Abstract :
PubMedSearch : Saxena_1999_Chem.Biol.Interact_119-120_61
PubMedID: 10421439

Title : Allosteric control of acetylcholinesterase activity by monoclonal antibodies -
Author(s) : Saxena A , Hur RS , Doctor BP
Ref : Biochemistry , 38 :15688 , 1999
PubMedID: 10569956

Title : The pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants: Further Evidence for a Push-Pull Mechanism - Saxena_1998_Biochemistry_37_15086
Author(s) : Saxena A , Viragh C , Frazier DS , Kovach IM , Maxwell DM , Lockridge O , Doctor BP
Ref : Biochemistry , 37 :15086 , 1998
Abstract :
PubMedSearch : Saxena_1998_Biochemistry_37_15086
PubMedID: 9790671

Title : Amino Acid Sequence of Horse Serum Butyrylcholinesterase -
Author(s) : Moorad DR , Luo C , Saxena A , Doctor BP , Garcia GE
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :145 , 1998
PubMedID:
Gene_locus related to this paper: horse-BCHE

Title : Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases - Saxena_1998_Mol.Pharmacol_53_112
Author(s) : Saxena A , Ashani Y , Raveh L , Stevenson D , Patel T , Doctor BP
Ref : Molecular Pharmacology , 53 :112 , 1998
Abstract :
PubMedSearch : Saxena_1998_Mol.Pharmacol_53_112
PubMedID: 9443938

Title : Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands -
Author(s) : Luo C , Ashani Y , Saxena A , Leader H , Maxwell DM , Taylor P , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :215 , 1998
PubMedID:

Title : pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants -
Author(s) : Viragh C , Saxena A , Frazier DS , Kovach IM , Lockridge O , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :247 , 1998
PubMedID:

Title : Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring - Campiani_1998_Bioorg.Med.Chem.Lett_8_1413
Author(s) : Campiani G , Kozikowski AP , Wang S , Ming L , Nacci V , Saxena A , Doctor BP
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1413 , 1998
Abstract :
PubMedSearch : Campiani_1998_Bioorg.Med.Chem.Lett_8_1413
PubMedID: 9871776

Title : The Role of Oligosaccharides in the Pharmacokinetics of Cholinesterases -
Author(s) : Saxena A , Ashani Y , Raveh L , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :283 , 1998
PubMedID:

Title : Allosteric control of acetylcholinesterase activity by monoclonal antibodies - Saxena_1998_Biochemistry_37_145
Author(s) : Saxena A , Hur RS , Doctor BP
Ref : Biochemistry , 37 :145 , 1998
Abstract :
PubMedSearch : Saxena_1998_Biochemistry_37_145
PubMedID: 9425034

Title : Comparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds -
Author(s) : Maxwell DM , Brecht KM , Saxena A , Feaster SR , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :387 , 1998
PubMedID:

Title : Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase - Saxena_1997_Biochemistry_36_7481
Author(s) : Saxena A , Raveh L , Ashani Y , Doctor BP
Ref : Biochemistry , 36 :7481 , 1997
Abstract :
PubMedSearch : Saxena_1997_Biochemistry_36_7481
PubMedID: 9200697

Title : Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning - Saxena_1997_Biochem.Pharmacol_54_269
Author(s) : Saxena A , Maxwell DM , Quinn DM , Radic Z , Taylor P , Doctor BP
Ref : Biochemical Pharmacology , 54 :269 , 1997
Abstract :
PubMedSearch : Saxena_1997_Biochem.Pharmacol_54_269
PubMedID: 9271331

Title : Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase - Saxena_1997_Biochemistry_36_14642
Author(s) : Saxena A , Redman AM , Jiang X , Lockridge O , Doctor BP
Ref : Biochemistry , 36 :14642 , 1997
Abstract :
PubMedSearch : Saxena_1997_Biochemistry_36_14642
PubMedID: 9398183

Title : Modulation of Catalysis and Inhibition of Fetal Bovine Serum Acetylcholinesterase by Monoclonal Antibodies -
Author(s) : Doctor BP , Gentry MK , Saxena A , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :141 , 1995
PubMedID:

Title : Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases - Gentry_1995_J.Neurochem_64_842
Author(s) : Gentry MK , Moorad DR , Hur RS , Saxena A , Ashani Y , Doctor BP
Ref : Journal of Neurochemistry , 64 :842 , 1995
Abstract :
PubMedSearch : Gentry_1995_J.Neurochem_64_842
PubMedID: 7830078

Title : Comparison of Acetylcholinesterase, Pyridostigmine, and HI-6 as Antidotes against Organophosphorus Compounds -
Author(s) : Maxwell DM , Brecht KM , Saxena A , Taylor P , Doctor BP
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :353 , 1995
PubMedID:

Title : Structural Analysis of the Asparagine-Linked Oligosaccharides of Cholinesterases -
Author(s) : Saxena A , Doctor BP
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :105 , 1995
PubMedID:

Title : Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases - Saxena_1994_Protein.Sci_3_1770
Author(s) : Saxena A , Qian N , Kovach IM , Kozikowski AP , Pang YP , Vellom DC , Radic Z , Quinn DM , Taylor P , Doctor BP
Ref : Protein Science , 3 :1770 , 1994
Abstract :
PubMedSearch : Saxena_1994_Protein.Sci_3_1770
PubMedID: 7849595

Title : The role of glutamate-199 in the aging of cholinesterase - Saxena_1993_Biochem.Biophys.Res.Commun_197_343
Author(s) : Saxena A , Doctor BP , Maxwell DM , Lenz DE , Radic Z , Taylor P
Ref : Biochemical & Biophysical Research Communications , 197 :343 , 1993
Abstract :
PubMedSearch : Saxena_1993_Biochem.Biophys.Res.Commun_197_343
PubMedID: 7902714

Title : Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies - Gentry_1993_Chem.Biol.Interact_87_227
Author(s) : Gentry MK , Saxena A , Ashani Y , Doctor BP
Ref : Chemico-Biological Interactions , 87 :227 , 1993
Abstract :
PubMedSearch : Gentry_1993_Chem.Biol.Interact_87_227
PubMedID: 7688272