| Title : Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates? - Schrag_1992_J.Biol.Chem_267_4300 |
| Author(s) : Schrag JD , Winkler FK , Cygler M |
| Ref : Journal of Biological Chemistry , 267 :4300 , 1992 |
| Abstract : Comparison of the fold of lipases from Geotrichum candidum and from human pancreas identified a high degree of similarity which was not expected on the basis of their amino acid sequences. Although both enzymes utilize a serine protease-like catalytic triad, they differ in the topological position of the acid. We speculate that these proteins are evolutionarily related and that the pancreatic lipase is an evolutionary intermediate in the pathway of migration of the catalytic acid to a new position within the fold. |
| ESTHER : Schrag_1992_J.Biol.Chem_267_4300 |
| PubMedSearch : Schrag_1992_J.Biol.Chem_267_4300 |
| PubMedID: 1537823 |
| Gene_locus related to this paper: geoca-1lipa |
| Gene_locus related to this paper: geoca-1lipa |
Schrag JD, Winkler FK, Cygler M (1992)
Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates?
Journal of Biological Chemistry
267 :4300
Schrag JD, Winkler FK, Cygler M (1992)
Journal of Biological Chemistry
267 :4300