Cygler M

General

Full name : Cygler Mirek

First name : Mirek

Mail : Biotechnology Research Institute NRCC, 6100 Royalmount Ave, Montreal, Quebec H4P 2R2

Zip Code :

City :

Country : Canada

Email : Miroslaw.cygler@usask.ca

Phone : 514-496-6321

Fax : 514-496-5143

Website :

Directory :

References (27)

Title : Defining substrate characteristics from 3D structure\; perspective on EstA structure - Schrag_2004_Structure.(Camb)_12_521
Author(s) : Schrag JD , Cygler M
Ref : Structure , 12 :521 , 2004
PubMedID: 15062074
Gene_locus related to this paper: aspni-EstA

Title : Structure and conformational flexibility of Candida rugosa lipase - Cygler_1999_Biochim.Biophys.Acta_1441_205
Author(s) : Cygler M , Schrag JD
Ref : Biochimica & Biophysica Acta , 1441 :205 , 1999
PubMedID: 10570248

Title : The open conformation of a Pseudomonas lipase - Schrag_1997_Structure_5_187
Author(s) : Schrag JD , Li Y , Cygler M , Lang D , Burgdorf T , Hecht HJ , Schmid RD , Schomburg D , Rydel TJ , Oliver JD , Strickland LC , Dunaway CM , Larson SB , Day J , McPherson A
Ref : Structure , 5 :187 , 1997
PubMedID: 9032074
Gene_locus related to this paper: burce-lipaa

Title : High-level production of recombinant Geotrichum candidum lipases in yeast Pichia pastoris - Holmquist_1997_Protein.Expr.Purif_11_35
Author(s) : Holmquist M , Tessier DC , Cygler M
Ref : Protein Expr Purif , 11 :35 , 1997
PubMedID: 9325136

Title : Structure as basis for understanding interfacial properties of lipases -
Author(s) : Cygler M , Schrag JD
Ref : Methods Enzymol , 284 :3 , 1997
PubMedID: 9379943

Title : Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae - Shilton_1997_Biochemistry_36_9002
Author(s) : Shilton BH , Thomas DY , Cygler M
Ref : Biochemistry , 36 :9002 , 1997
PubMedID: 9220988

Title : Lipases and alpha\/beta hydrolase fold - Schrag_1997_Methods.Enzymol_284_85
Author(s) : Schrag JD , Cygler M
Ref : Methods Enzymol , 284 :85 , 1997
PubMedID: 9379946

Title : Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae - Shilton_1996_Protein.Sci_5_395
Author(s) : Shilton BH , Li Y , Tessier D , Thomas DY , Cygler M
Ref : Protein Science , 5 :395 , 1996
PubMedID: 8745419
Gene_locus related to this paper: yeast-kex01

Title : Purification and characterization of a Penicillium sp. lipase which discriminates against diglycerides - Gulomova_1996_Lipids_31_379
Author(s) : Gulomova K , Ziomek E , Schrag JD , Davranov K , Cygler M
Ref : Lipids , 31 :379 , 1996
PubMedID: 8743049

Title : Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II - Bertolini_1995_Eur.J.Biochem_228_863
Author(s) : Bertolini MC , Schrag JD , Cygler M , Ziomek E , Thomas DY , Vernet T
Ref : European Journal of Biochemistry , 228 :863 , 1995
PubMedID: 7737187
Gene_locus related to this paper: geoca-1lipa , geoca-2lipa

Title : Structural determinants defining common stereoselectivity of lipases toward secondary alcohols - Cygler_1995_Can.J.Microbiol_41 Suppl 1_289
Author(s) : Cygler M , Grochulski P , Schrag JD
Ref : Can J Microbiol , 41 Suppl 1 :289 , 1995
PubMedID: 7606666

Title : Substrate Binding Site and the Role of the FLAP Loop in Candida rugosa Lipase, A Close Relative of Acetylcholinesterase -
Author(s) : Cygler M , Grochulski P , Schrag JD
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :71 , 1995
PubMedID:

Title : Redesigning the active site of Geotrichum candidum lipase - Schrag_1995_Protein.Eng_8_835
Author(s) : Schrag JD , Vernet T , Laramee L , Thomas DY , Recktenwald A , Okoniewska M , Ziomek E , Cygler M
Ref : Protein Engineering , 8 :835 , 1995
PubMedID: 8637854

Title : Polymorphism in the lipase genes of Geotrichum candidum strains - Bertolini_1994_Eur.J.Biochem_219_119
Author(s) : Bertolini MC , Laramee L , Thomas DY , Cygler M , Schrag JD , Vernet T
Ref : European Journal of Biochemistry , 219 :119 , 1994
PubMedID: 8306978
Gene_locus related to this paper: geoca-1lipa , geoca-2lipa

Title : Two conformational states of Candida rugosa lipase - Grochulski_1994_Protein.Sci_3_82
Author(s) : Grochulski P , Li Y , Schrag JD , Cygler M
Ref : Protein Science , 3 :82 , 1994
PubMedID: 8142901
Gene_locus related to this paper: canru-1lipa

Title : Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase - Grochulski_1994_Biochemistry_33_3494
Author(s) : Grochulski P , Bouthillier F , Kazlauskas RJ , Serreqi AN , Schrag JD , Ziomek E , Cygler M
Ref : Biochemistry , 33 :3494 , 1994
PubMedID: 8142346
Gene_locus related to this paper: canru-1lipa

Title : A structural basis for the chiral preferences of lipases -
Author(s) : Cygler M , Grochulski P , Kazlauskas RJ , Schrag JD , Bouthillier F , Rubin B , Serreqi AN , Gupta AK
Ref : Journal of the American Chemical Society , 116 :3180 , 1994
PubMedID:
Gene_locus related to this paper: canru-1lipa

Title : 1.8 A refined structure of the lipase from Geotrichum candidum - Schrag_1993_J.Mol.Biol_230_575
Author(s) : Schrag JD , Cygler M
Ref : Journal of Molecular Biology , 230 :575 , 1993
PubMedID: 8464065
Gene_locus related to this paper: geoca-1lipa , geoca-2lipa

Title : Enzymes. Snapshots along the pathway [news\; comment] -
Author(s) : Cygler M
Ref : Nature , 363 :674 , 1993
PubMedID: 8515808

Title : Insights into interfacial activation from an open structure of Candida rugosa lipase - Grochulski_1993_J.Biol.Chem_268_12843
Author(s) : Grochulski P , Li Y , Schrag JD , Bouthillier F , Smith P , Harrison D , Rubin B , Cygler M
Ref : Journal of Biological Chemistry , 268 :12843 , 1993
PubMedID: 8509417
Gene_locus related to this paper: canru-1lipa , geoca-1lipa

Title : Cloning and expression of Geotrichum candidum lipase II gene in yeast. Probing of the enzyme active site by site-directed mutagenesis - Vernet_1993_J.Biol.Chem_268_26212
Author(s) : Vernet T , Ziomek E , Recktenwald A , Schrag JD , de Montigny C , Tessier DC , Thomas DY , Cygler M
Ref : Journal of Biological Chemistry , 268 :26212 , 1993
PubMedID: 7902836

Title : Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins - Cygler_1993_Protein.Sci_2_366
Author(s) : Cygler M , Schrag JD , Sussman JL , Harel M , Silman I , Gentry MK , Doctor BP
Ref : Protein Science , 2 :366 , 1993
PubMedID: 8453375

Title : Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates? - Schrag_1992_J.Biol.Chem_267_4300
Author(s) : Schrag JD , Winkler FK , Cygler M
Ref : Journal of Biological Chemistry , 267 :4300 , 1992
PubMedID: 1537823
Gene_locus related to this paper: geoca-1lipa

Title : The alpha\/beta hydrolase fold - Ollis_1992_Prot.Engin_5_197
Author(s) : Ollis DL , Cheah E , Cygler M , Dijkstra B , Frolow F , Franken SM , Harel M , Remington SJ , Silman I , Schrag JD , Sussman JL , Verschueren KHG , Goldman A
Ref : Protein Engineering , 5 :197 , 1992
PubMedID: 1409539

Title : Sequence Alignment of Esterases and Lipases Based on 3-D Structures of Two Members of This Family -
Author(s) : Cygler M , Schrag JD
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :109 , 1992
PubMedID:

Title : Advances in structural understanding of lipases -
Author(s) : Cygler M , Schrag JD , Ergan F
Ref : Biotechnol Genet Eng Rev , 10 :143 , 1992
PubMedID: 1301738

Title : Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum - Schrag_1991_Nature_351_761
Author(s) : Schrag JD , Li YG , Wu S , Cygler M
Ref : Nature , 351 :761 , 1991
PubMedID: 2062369
Gene_locus related to this paper: geoca-1lipa