Schultz_1996_Cancer.Res_56_1997

Reference

Title : Identification of two candidate tumor suppressor genes on chromosome 17p13.3 - Schultz_1996_Cancer.Res_56_1997
Author(s) : Schultz DC , Vanderveer L , Berman DB , Hamilton TC , Wong AJ , Godwin AK
Ref : Cancer Research , 56 :1997 , 1996
Abstract :

A second tumor suppressor locus on 17p that is distinct from TP53 has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, with no known functional motifs. Sequence comparison of OVCA1 and OVCA2 revealed extensive sequence identity and similarity to hypothetical proteins from Saccharomyces cerevisiae, Caenorhabditis elegans, and Rattus species. Northern blot analysis reveals that OVCA1 and OVCA2 mRNA were expressed in normal surface epithelial cells of the ovary, but the level of this transcript is significantly reduced or is undetectable in 92% (11/12) of the ovarian tumors and tumor cell lines analyzed. The location, high degree of amino acid conservation, and reduced expression in ovarian tumors and tumor cell lines suggest that decreased expression of these two genes contributes to ovarian tumorigenesis and should be considered candidate tumor suppressor genes.

PubMedSearch : Schultz_1996_Cancer.Res_56_1997
PubMedID: 8616839
Gene_locus related to this paper: human-OVCA2

Related information

Gene_locus human-OVCA2
Family human-OVCA2    FSH1

Citations formats

Schultz DC, Vanderveer L, Berman DB, Hamilton TC, Wong AJ, Godwin AK (1996)
Identification of two candidate tumor suppressor genes on chromosome 17p13.3
Cancer Research 56 :1997

Schultz DC, Vanderveer L, Berman DB, Hamilton TC, Wong AJ, Godwin AK (1996)
Cancer Research 56 :1997