Sekuri_2006_Anadolu.Kardiyol.Derg_6_132

Reference

Title : Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients - Sekuri_2006_Anadolu.Kardiyol.Derg_6_132
Author(s) : Sekuri C , Cam FS , Tengiz I , Ercan E , Bayturan O , Berdeli A
Ref : Anadolu Kardiyol Derg , 6 :132 , 2006
Abstract : OBJECTIVE: Platelet-activating factor (PAF) is a phospholipid with multiple actions that is involved in inflammatory diseases as well as in atherogenesis. It is inactivated by a plasma enzyme, PAF-acetylhydrolase (PAF-AH). Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD).
METHODS: One hundred and fifteen unrelated Turkish patients with a diagnosis of premature CAD and 128 unrelated healthy subjects were enrolled in this study. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
RESULTS: The prevalence of the G994T mutation in the patients was 2.60 % (heterozygote), and 0 % in the controls. There was no significant difference in allele frequency and genotype distribution among the study groups. CONCLUSION: The G9943T mutation in the plasma PAF acetylhydrolase gene is not associated with premature CAD in Turkish subjects.
ESTHER : Sekuri_2006_Anadolu.Kardiyol.Derg_6_132
PubMedSearch : Sekuri_2006_Anadolu.Kardiyol.Derg_6_132
PubMedID: 16766276
Gene_locus related to this paper: human-PLA2G7

Related information

Gene_locus related to this paper: human-PLA2G7

Citations formats

Sekuri C, Cam FS, Tengiz I, Ercan E, Bayturan O, Berdeli A (2006)
Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients
Anadolu Kardiyol Derg 6 :132

Sekuri C, Cam FS, Tengiz I, Ercan E, Bayturan O, Berdeli A (2006)
Anadolu Kardiyol Derg 6 :132