Alternative name(s) : Phospholipase A2 group VII deficiency, PLA2G7 deficiency, PAFAH deficiency, Platelet-activating factor acetylhydrolase deficiency
Gene_locus : 1
Mutation : 9
OMIM : 601690 , 600807 , 147050 , 614278
Comment
(from OMIM) Platelet-activating factor (PAF) is a biologically active phospholipid with diverse potent biologic effects. Stafforini et al. (1996) noted that PAF has been implicated as a mediator of physiologic processes, such as signaling and activation of proinflammatory cells, alteration of vascular permeability, and stimulation of glycogen metabolism among many others. In addition to its role as a physiologic mediator, PAF is associated with a pathology of several human diseases, particularly allergy and inflammation, affecting the respiratory, vascular, digestive, and reproductive systems.PAF is degraded to inactive products by hydrolysis of the acetyl group at the sn-2 position to produce the biologically inactive products LYSO-PAF and acetate. This reaction is catalyzed by PAF acetylhydrolase. Miwa et al. (1988) described an autosomal recessive form of PAF acetylhydrolase deficiency which has been observed only in Japanese. PAF acetylhydrolase activity was absent in 4% of the Japanese population. Previously known loss-of-function mutations were not found but 3 common variants of the PAFAH gene were identified: arg92 to his (exon 4), ile198 to thr (exon 7), and ala379 to val (exon 11). The variant allele thr198 was found to be highly associated with total IgE concentrations in an atopic population and with 'asthma' in an asthmatic population. The variant allele val379 was found to be highly associated with 'specific sensitization' in the atopic population and with 'asthma' in the asthmatic population. There is an association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease
| Title : Association Lp-PLA2 Gene Polymorphisms with Coronary Heart Disease - Ma_2022_Dis.Markers_2022_9775699 |
| Author(s) : Ma S , Ding L , Cai M , Chen L , Yan B , Yang J |
| Ref : Dis Markers , 2022 :9775699 , 2022 |
| Abstract : |
| PubMedSearch : Ma_2022_Dis.Markers_2022_9775699 |
| PubMedID: 35818585 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme - Khan_2020_J.Inflamm.Res_13_1125 |
| Author(s) : Khan MI , Hariprasad G |
| Ref : J Inflamm Res , 13 :1125 , 2020 |
| Abstract : |
| PubMedSearch : Khan_2020_J.Inflamm.Res_13_1125 |
| PubMedID: 33364808 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Phospholipase A2 is an Inflammatory Predictor in Cardiovascular Diseases: Is there any Spacious Room to Prove the Causation? - Santoso_2020_Curr.Cardiol.Rev_16_3 |
| Author(s) : Santoso A , Heriansyah T , Rohman MS |
| Ref : Curr Cardiol Rev , 16 :3 , 2020 |
| Abstract : |
| PubMedSearch : Santoso_2020_Curr.Cardiol.Rev_16_3 |
| PubMedID: 31146670 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The association between the D166E polymorphism of the lipoprotein associated phospholipase A2 and risk of myocardial infarction - Zhang_2019_Eur.Rev.Med.Pharmacol.Sci_23_3960 |
| Author(s) : Zhang MM , Zhang CG , Yang CJ , Zhao P , Li YL |
| Ref : Eur Rev Med Pharmacol Sci , 23 :3960 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_Eur.Rev.Med.Pharmacol.Sci_23_3960 |
| PubMedID: 31115024 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population - Chi_2018_J.Thromb.Thrombolysis_46_125 |
| Author(s) : Chi Y , Shi C , Zhang X , Xi Y |
| Ref : J Thromb Thrombolysis , 46 :125 , 2018 |
| Abstract : |
| PubMedSearch : Chi_2018_J.Thromb.Thrombolysis_46_125 |
| PubMedID: 29728838 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib - Yeo_2017_PLoS.One_12_e0182115 |
| Author(s) : Yeo A , Li L , Warren L , Aponte J , Fraser D , King K , Johansson K , Barnes A , Macphee C , Davies R , Chissoe S , Tarka E , O'Donoghue ML , White HD , Wallentin L , Waterworth D |
| Ref : PLoS ONE , 12 :e0182115 , 2017 |
| Abstract : |
| PubMedSearch : Yeo_2017_PLoS.One_12_e0182115 |
| PubMedID: 28753643 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure - Kim_2017_PLoS.One_12_e0173611 |
| Author(s) : Kim M , Yoo HJ , Jang HY , Lee SH , Lee JH |
| Ref : PLoS ONE , 12 :e0173611 , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_PLoS.One_12_e0173611 |
| PubMedID: 28334001 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between Lp-PLA2 and coronary heart disease in Chinese patients - Yang_2017_J.Int.Med.Res_45_159 |
| Author(s) : Yang L , Liu Y , Wang S , Liu T , Cong H |
| Ref : J Internal Medicine Res , 45 :159 , 2017 |
| Abstract : |
| PubMedSearch : Yang_2017_J.Int.Med.Res_45_159 |
| PubMedID: 28222638 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis - Santoso_2017_Am.J.Cardiovasc.Dis_7_122 |
| Author(s) : Santoso A , Maulana R , Alzahra F , Maghfirah I , Putrinarita AD , Heriansyah T |
| Ref : Am J Cardiovasc Dis , 7 :122 , 2017 |
| Abstract : |
| PubMedSearch : Santoso_2017_Am.J.Cardiovasc.Dis_7_122 |
| PubMedID: 29348973 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of Lp-PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population - Ni_2017_J.Biochem.Mol.Toxicol_31_ |
| Author(s) : Ni J , Gu H , Hu W , Zhou F , Zhu X , Wang K |
| Ref : J Biochem Mol Toxicol , 31 : , 2017 |
| Abstract : |
| PubMedSearch : Ni_2017_J.Biochem.Mol.Toxicol_31_ |
| PubMedID: 28960681 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction - Cahyaningtias_2016_Genes.Dis_3_289 |
| Author(s) : Cahyaningtias M , Rohman MS , Widodo , Wahjono Adi A , Yuda R , Indrayana Y , Putri JF , Rusdianto , Lukitasari M , Hendrawan D |
| Ref : Genes Dis , 3 :289 , 2016 |
| Abstract : |
| PubMedSearch : Cahyaningtias_2016_Genes.Dis_3_289 |
| PubMedID: 30258899 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population - Haghdoost_2016_Iran.J.Neurol_15_80 |
| Author(s) : Haghdoost F , Gharzi M , Faez F , Hosseinzadeh E , Tajaddini M , Ra Ei L , Asgari F , Banihashemi M , Masjedi SS , Zandifar A , Haghjooy-Javanmard S |
| Ref : Iran Journal of Neurology , 15 :80 , 2016 |
| Abstract : |
| PubMedSearch : Haghdoost_2016_Iran.J.Neurol_15_80 |
| PubMedID: 27326362 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults - Millwood_2016_Int.J.Epidemiol_45_1588 |
| Author(s) : Millwood IY , Bennett DA , Walters RG , Clarke R , Waterworth D , Johnson T , Chen Y , Yang L , Guo Y , Bian Z , Hacker A , Yeo A , Parish S , Hill MR , Chissoe S , Peto R , Cardon L , Collins R , Li L , Chen Z |
| Ref : Int J Epidemiol , 45 :1588 , 2016 |
| Abstract : |
| PubMedSearch : Millwood_2016_Int.J.Epidemiol_45_1588 |
| PubMedID: 27301456 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population - Karasawa_2015_Enzymes_38_117 |
| Author(s) : Karasawa K |
| Ref : Enzymes , 38 :117 , 2015 |
| Abstract : |
| PubMedSearch : Karasawa_2015_Enzymes_38_117 |
| PubMedID: 26612650 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population - Li_2011_Ann.Hum.Genet_75_605 |
| Author(s) : Li L , Qi L , Lv N , Gao Q , Cheng Y , Wei Y , Ye J , Yan X , Dang A |
| Ref : Ann Hum Genet , 75 :605 , 2011 |
| Abstract : |
| PubMedSearch : Li_2011_Ann.Hum.Genet_75_605 |
| PubMedID: 21834908 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Carriage of the V279F null allele within the gene encoding Lp-PLA(2) is protective from coronary artery disease in South Korean males - Jang_2011_PLoS.One_6_e18208 |
| Author(s) : Jang Y , Waterworth D , Lee JE , Song K , Kim S , Kim HS , Park KW , Cho HJ , Oh IY , Park JE , Lee BS , Ku HJ , Shin DJ , Lee JH , Jee SH , Han BG , Jang HY , Cho EY , Vallance P , Whittaker J , Cardon L , Mooser V |
| Ref : PLoS ONE , 6 :e18208 , 2011 |
| Abstract : |
| PubMedSearch : Jang_2011_PLoS.One_6_e18208 |
| PubMedID: 21490708 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis - Zheng_2011_Mol.Biol.Rep_38_4089 |
| Author(s) : Zheng GH , Chen HY , Xiong SQ , Chu JF |
| Ref : Mol Biol Rep , 38 :4089 , 2011 |
| Abstract : |
| PubMedSearch : Zheng_2011_Mol.Biol.Rep_38_4089 |
| PubMedID: 21107710 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome - Fan_2010_Hum.Reprod_25_1288 |
| Author(s) : Fan P , Liu Hw , Wang XS , Zhang F , Song Q , Li Q , Wu HM , Bai H |
| Ref : Hum Reprod , 25 :1288 , 2010 |
| Abstract : |
| PubMedSearch : Fan_2010_Hum.Reprod_25_1288 |
| PubMedID: 20185515 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : PLA2G7 gene polymorphisms and coronary heart disease risk: a meta-analysis - Wang_2010_Thromb.Res_126_498 |
| Author(s) : Wang Q , Hao Y , Mo X , Wang L , Lu X , Huang J , Cao J , Li H , Gu D |
| Ref : Thromb Res , 126 :498 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_Thromb.Res_126_498 |
| PubMedID: 20926117 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study) - Hoffmann_2009_J.Thromb.Haemost_7_41 |
| Author(s) : Hoffmann MM , Winkler K , Renner W , Winkelmann BR , Seelhorst U , Wellnitz B , Boehm BO , Marz W |
| Ref : J Thromb Haemost , 7 :41 , 2009 |
| Abstract : |
| PubMedSearch : Hoffmann_2009_J.Thromb.Haemost_7_41 |
| PubMedID: 18983494 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study - Hou_2009_Hum.Genet_125_11 |
| Author(s) : Hou L , Chen S , Yu H , Lu X , Chen J , Wang L , Huang J , Fan Z , Gu D |
| Ref : Hum Genet , 125 :11 , 2009 |
| Abstract : |
| PubMedSearch : Hou_2009_Hum.Genet_125_11 |
| PubMedID: 19034521 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype - Li_2009_J.Clin.Pharm.Ther_34_447 |
| Author(s) : Li S , Stuart L , Zhang Y , Meduri GU , Umberger R , Yates CR |
| Ref : J Clin Pharm Ther , 34 :447 , 2009 |
| Abstract : |
| PubMedSearch : Li_2009_J.Clin.Pharm.Ther_34_447 |
| PubMedID: 19583678 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Effects of G994T in the Lp-PLA2 gene on the plasma oxidized LDL level and carotid intima-media thickness in Japanese: the Shimane study - Wang_2009_Am.J.Hypertens_22_742 |
| Author(s) : Wang T , Karino K , Yamasaki M , Zhang Y , Masuda J , Yamaguchi S , Shiwaku K , Nabika T |
| Ref : Am J Hypertens , 22 :742 , 2009 |
| Abstract : |
| PubMedSearch : Wang_2009_Am.J.Hypertens_22_742 |
| PubMedID: 19373214 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets - Sutton_2008_Hum.Mol.Genet_17_1318 |
| Author(s) : Sutton BS , Crosslin DR , Shah SH , Nelson SC , Bassil A , Hale AB , Haynes C , Goldschmidt-Clermont PJ , Vance JM , Seo D , Kraus WE , Gregory SG , Hauser ER |
| Ref : Hum Mol Genet , 17 :1318 , 2008 |
| Abstract : |
| PubMedSearch : Sutton_2008_Hum.Mol.Genet_17_1318 |
| PubMedID: 18204052 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Comprehensive evaluation of genetic and environmental factors influencing the plasma lipoprotein-associated phospholipase A2 activity in a Japanese population - Zhang_2007_Hypertens.Res_30_403 |
| Author(s) : Zhang SY , Shibata H , Karino K , Wang BY , Kobayashi S , Masuda J , Nabika T |
| Ref : Hypertens Res , 30 :403 , 2007 |
| Abstract : |
| PubMedSearch : Zhang_2007_Hypertens.Res_30_403 |
| PubMedID: 17587752 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men - Jang_2006_J.Clin.Endocrinol.Metab_91_3521 |
| Author(s) : Jang Y , Kim OY , Koh SJ , Chae JS , Ko YG , Kim JY , Cho H , Jeong TS , Lee WS , Ordovas JM , Lee JH |
| Ref : J Clinical Endocrinology Metab , 91 :3521 , 2006 |
| Abstract : |
| PubMedSearch : Jang_2006_J.Clin.Endocrinol.Metab_91_3521 |
| PubMedID: 16787988 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction - Liu_2006_J.Thromb.Haemost_4_1023 |
| Author(s) : Liu PY , Li YH , Wu HL , Chao TH , Tsai LM , Lin LJ , Shi GY , Chen JH |
| Ref : J Thromb Haemost , 4 :1023 , 2006 |
| Abstract : |
| PubMedSearch : Liu_2006_J.Thromb.Haemost_4_1023 |
| PubMedID: 16689754 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients - Sekuri_2006_Anadolu.Kardiyol.Derg_6_132 |
| Author(s) : Sekuri C , Cam FS , Tengiz I , Ercan E , Bayturan O , Berdeli A |
| Ref : Anadolu Kardiyol Derg , 6 :132 , 2006 |
| Abstract : |
| PubMedSearch : Sekuri_2006_Anadolu.Kardiyol.Derg_6_132 |
| PubMedID: 16766276 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese - Mashiba_2005_Circ.J_69_1466 |
| Author(s) : Mashiba J , Koike G , Kamiunten H , Ikeda M , Sunagawa K |
| Ref : Circ J , 69 :1466 , 2005 |
| Abstract : |
| PubMedSearch : Mashiba_2005_Circ.J_69_1466 |
| PubMedID: 16308493 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease - Ninio_2004_Hum.Mol.Genet_13_1341 |
| Author(s) : Ninio E , Tregouet D , Carrier JL , Stengel D , Bickel C , Perret C , Rupprecht HJ , Cambien F , Blankenberg S , Tiret L |
| Ref : Hum Mol Genet , 13 :1341 , 2004 |
| Abstract : |
| PubMedSearch : Ninio_2004_Hum.Mol.Genet_13_1341 |
| PubMedID: 15115767 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe - Abuzeid_2003_Atherosclerosis_168_283 |
| Author(s) : Abuzeid AM , Hawe E , Humphries SE , Talmud PJ |
| Ref : Atherosclerosis , 168 :283 , 2003 |
| Abstract : |
| PubMedSearch : Abuzeid_2003_Atherosclerosis_168_283 |
| PubMedID: 12801611 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients - Yamamoto_2003_Diabetes.Res.Clin.Pract_59_219 |
| Author(s) : Yamamoto I , Fujitsu J , Nohnen S , Igarashi T , Motomura T , Inaba M , Tsubakimori S , Azuma J |
| Ref : Diabetes Res Clin Pract , 59 :219 , 2003 |
| Abstract : |
| PubMedSearch : Yamamoto_2003_Diabetes.Res.Clin.Pract_59_219 |
| PubMedID: 12590019 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Evidence for the existence of the PAF acetylhydrolase mutation (Val279Phe) in non-Japanese populations: a preliminary study in Turkey, Azerbaijan, and Kyrgyzstan - Balta_2001_Thromb.Res_101_231 |
| Author(s) : Balta G , Gurgey A , Kudayarov DK , Tunc B , Altay C |
| Ref : Thromb Res , 101 :231 , 2001 |
| Abstract : |
| PubMedSearch : Balta_2001_Thromb.Res_101_231 |
| PubMedID: 11248283 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group - Packard_2000_N.Engl.J.Med_343_1148 |
| Author(s) : Packard CJ , O'Reilly DS , Caslake MJ , McMahon AD , Ford I , Cooney J , Macphee CH , Suckling KE , Krishna M , Wilkinson FE , Rumley A , Lowe GD |
| Ref : N Engl J Med , 343 :1148 , 2000 |
| Abstract : |
| PubMedSearch : Packard_2000_N.Engl.J.Med_343_1148 |
| PubMedID: 11036120 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma - Kruse_2000_Am.J.Hum.Genet_66_1522 |
| Author(s) : Kruse S , Mao XQ , Heinzmann A , Blattmann S , Roberts MH , Braun S , Gao PS , Forster J , Kuehr J , Hopkin JM , Shirakawa T , Deichmann KA |
| Ref : American Journal of Human Genetics , 66 :1522 , 2000 |
| Abstract : |
| PubMedSearch : Kruse_2000_Am.J.Hum.Genet_66_1522 |
| PubMedID: 10733466 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome - Xu_2000_Am.J.Kidney.Dis_36_42 |
| Author(s) : Xu H , Iijima K , Shirakawa T , Shiozawa S , Miwa M , Yamaoka K , Kawamura N , Nakamura H , Yoshikawa N |
| Ref : Am J Kidney Dis , 36 :42 , 2000 |
| Abstract : |
| PubMedSearch : Xu_2000_Am.J.Kidney.Dis_36_42 |
| PubMedID: 10873870 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma - Stafforini_1999_J.Clin.Invest_103_989 |
| Author(s) : Stafforini DM , Numao T , Tsodikov A , Vaitkus D , Fukuda T , Watanabe N , Fueki N , McIntyre TM , Zimmerman GA , Makino S , Prescott SM |
| Ref : J Clinical Investigation , 103 :989 , 1999 |
| Abstract : |
| PubMedSearch : Stafforini_1999_J.Clin.Invest_103_989 |
| PubMedID: 10194471 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy - Tanaka_1999_Am.J.Kidney.Dis_34_289 |
| Author(s) : Tanaka R , Iijima K , Xu H , Inoue Y , Murakami R , Shirakawa T , Nishiyama K , Miwa M , Shiozawa S , Nakamura H , Yoshikawa N |
| Ref : Am J Kidney Dis , 34 :289 , 1999 |
| Abstract : |
| PubMedSearch : Tanaka_1999_Am.J.Kidney.Dis_34_289 |
| PubMedID: 10430976 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A genome-wide search for linkage to asthma. German Asthma Genetics Group - Wjst_1999_Genomics_58_1 |
| Author(s) : Wjst M , Fischer G , Immervoll T , Jung M , Saar K , Rueschendorf F , Reis A , Ulbrecht M , Gomolka M , Weiss EH , Jaeger L , Nickel R , Richter K , Kjellman NI , Griese M , von Berg A , Gappa M , Riedel F , Boehle M , van Koningsbruggen S , Schoberth P , Szczepanski R , Dorsch W , Silbermann M , Loesgen S , Scholz M , Bickeboller H , Wichmann HE |
| Ref : Genomics , 58 :1 , 1999 |
| Abstract : |
| PubMedSearch : Wjst_1999_Genomics_58_1 |
| PubMedID: 10333435 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma - Ober_1998_Hum.Mol.Genet_7_1393 |
| Author(s) : Ober C , Cox NJ , Abney M , Di Rienzo A , Lander ES , Changyaleket B , Gidley H , Kurtz B , Lee J , Nance M , Pettersson A , Prescott J , Richardson A , Schlenker E , Summerhill E , Willadsen S , Parry R |
| Ref : Hum Mol Genet , 7 :1393 , 1998 |
| Abstract : |
| PubMedSearch : Ober_1998_Hum.Mol.Genet_7_1393 |
| PubMedID: 9700192 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children - Xu_1998_Kidney.Int_54_1867 |
| Author(s) : Xu H , Iijima K , Shiozawa S , Tanaka SS , Inoue Y , Shirakawa T , Nishiyama K , Miwa M , Nakamura H , Yoshikawa N |
| Ref : Kidney Int , 54 :1867 , 1998 |
| Abstract : |
| PubMedSearch : Xu_1998_Kidney.Int_54_1867 |
| PubMedID: 9853251 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia - Bell_1997_Biochem.Biophys.Res.Commun_241_630 |
| Author(s) : Bell R , Collier DA , Rice SQ , Roberts GW , Macphee CH , Kerwin RW , Price J , Gloger IS |
| Ref : Biochemical & Biophysical Research Communications , 241 :630 , 1997 |
| Abstract : |
| PubMedSearch : Bell_1997_Biochem.Biophys.Res.Commun_241_630 |
| PubMedID: 9434759 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->\;Phe) is a genetic risk factor for stroke - Hiramoto_1997_Stroke_28_2417 |
| Author(s) : Hiramoto M , Yoshida H , Imaizumi T , Yoshimizu N , Satoh K |
| Ref : Stroke , 28 :2417 , 1997 |
| Abstract : |
| PubMedSearch : Hiramoto_1997_Stroke_28_2417 |
| PubMedID: 9412624 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase - Stafforini_1996_J.Clin.Invest_97_2784 |
| Author(s) : Stafforini DM , Satoh K , Atkinson DL , Tjoelker LW , Eberhardt C , Yoshida H , Imaizumi T , Takamatsu S , Zimmerman GA , McIntyre TM , Gray PW , Prescott SM |
| Ref : J Clinical Investigation , 97 :2784 , 1996 |
| Abstract : |
| PubMedSearch : Stafforini_1996_J.Clin.Invest_97_2784 |
| PubMedID: 8675689 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states - |
| Author(s) : Nadel JA |
| Ref : J Clinical Investigation , 97 :2689 , 1996 |
| PubMedID: 8675676 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Anti-inflammatory properties of a platelet-activating factor acetylhydrolase - Tjoelker_1995_Nature_374_549 |
| Author(s) : Tjoelker LW , Wilder C , Eberhardt C , Stafforini DM |
| Ref : Nature , 374 :549 , 1995 |
| Abstract : |
| PubMedSearch : Tjoelker_1995_Nature_374_549 |
| PubMedID: 7700381 |
| Gene_locus related to this paper: bovin-pafa , canfa-pafa , chick-pafa , human-PLA2G7 , mouse-pafa |
| Title : Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children - Miwa_1988_J.Clin.Invest_82_1983 |
| Author(s) : Miwa M , Miyake T , Yamanaka T , Sugatani J , Suzuki Y , Sakata S , Araki Y , Matsumoto M |
| Ref : J Clinical Investigation , 82 :1983 , 1988 |
| Abstract : |
| PubMedSearch : Miwa_1988_J.Clin.Invest_82_1983 |
| PubMedID: 3198761 |
| Gene_locus related to this paper: human-PLA2G7 |