Shek_1976_J.Med.Chem_19_113

Reference

Title : Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form - Shek_1976_J.Med.Chem_19_113
Author(s) : Shek E , Higuchi T , Bodor N
Ref : Journal of Medicinal Chemistry , 19 :113 , 1976
Abstract :

Administration of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, the pro-drug form of 2-PAM, resulted in an average of 13-fold increase in the amount of 2-PAM delivered into the brain of mice as compared to the administration of 2-PAM. The pro-drug which crossed the BBB resulted in a dramatic increase in the reactivation of AChE blocked by DFP. In vivo studies of the "aging" of the phosphorylated AChE in the brain of mice could also be studied using pro-2-PAM.

PubMedSearch : Shek_1976_J.Med.Chem_19_113
PubMedID: 1246032

Related information

Reactivator 2-PAM    pro-2PAM

Citations formats

Shek E, Higuchi T, Bodor N (1976)
Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form
Journal of Medicinal Chemistry 19 :113

Shek E, Higuchi T, Bodor N (1976)
Journal of Medicinal Chemistry 19 :113