| Title : Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors - Sheng_2005_Bioorg.Med.Chem.Lett_15_3834 |
| Author(s) : Sheng R , Lin X , Li J , Jiang Y , Shang Z , Hu Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3834 , 2005 |
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Abstract :
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE. |
| PubMedSearch : Sheng_2005_Bioorg.Med.Chem.Lett_15_3834 |
| PubMedID: 15993600 |
| Inhibitor | BYYT-25 |
Sheng R, Lin X, Li J, Jiang Y, Shang Z, Hu Y (2005)
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett
15 :3834
Sheng R, Lin X, Li J, Jiang Y, Shang Z, Hu Y (2005)
Bioorganic & Medicinal Chemistry Lett
15 :3834