BYYT-25
General
Type : Derivative of Donepezil, Inden, Pyrrolidine
Chemical_Nomenclature : 5,6-dimethoxy-2-[4-(pyrrolidin-1-ylmethyl)phenoxy]-2,3-dihydroinden-1-one
Canonical SMILES : COC1=C(C=C2C(=C1)CC(C2=O)OC3=CC=C(C=C3)CN4CCCC4)OC
InChI : InChI=1S\/C22H25NO4\/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)27-17-7-5-15(6-8-17)14-23-9-3-4-10-23\/h5-8,11,13,21H,3-4,9-10,12,14H2,1-2H3
InChIKey : NHKALDYCLFCPIU-UHFFFAOYSA-N
Other name(s) : CHEMBL180483 || SCHEMBL8921502 || BDBM50169850
Target
Families : BYYT-25 ligand of proteins in family
ACHE
BCHE
Cholinesterase
References (2)
| Title : Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H(3)R and BACE 1 inhibitory activities - Huang_2011_Bioorg.Med.Chem_19_7158 |
| Author(s) : Huang W , Tang L , Shi Y , Huang S , Xu L , Sheng R , Wu P , Li J , Zhou N , Hu Y |
| Ref : Bioorganic & Medicinal Chemistry , 19 :7158 , 2011 |
| Abstract : |
| PubMedSearch : Huang_2011_Bioorg.Med.Chem_19_7158 |
| PubMedID: 22019465 |
| Title : Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors - Sheng_2005_Bioorg.Med.Chem.Lett_15_3834 |
| Author(s) : Sheng R , Lin X , Li J , Jiang Y , Shang Z , Hu Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3834 , 2005 |
| Abstract : |
| PubMedSearch : Sheng_2005_Bioorg.Med.Chem.Lett_15_3834 |
| PubMedID: 15993600 |