| Title : Preparation of optically pure chiral amines by lipase -catalyzed enantioselective hydrolysis of N-acyl-amines - Smidt_1996_Biotechnol.Tech_10_335 |
| Author(s) : Smidt H , Fischer A , Fischer P , Schmid RD |
| Ref : Biotechnology Techniques , 10 :335 , 1996 |
|
Abstract :
A new and effective method using lipase from Candida antarctica (native or Novozym SP-435) for the preparation of enantiopure primary R-amines is reported. Hydrolysis of rac-N-acetyl-amines resulted in high conversion > 40% (168 hrs) and > 48 % (> 240 hrs) and enantiomeric excesses (> 99 %ee) for both the product and the remaining substrate |
| PubMedSearch : Smidt_1996_Biotechnol.Tech_10_335 |
| PubMedID: |
| Gene_locus related to this paper: canar-LipB |
| Substrate | Capsaicin |
| Gene_locus | canar-LipB |
Smidt H, Fischer A, Fischer P, Schmid RD (1996)
Preparation of optically pure chiral amines by lipase -catalyzed enantioselective hydrolysis of N-acyl-amines
Biotechnology Techniques
10 :335
Smidt H, Fischer A, Fischer P, Schmid RD (1996)
Biotechnology Techniques
10 :335