Capsaicin
A non-narcotic analgesic, a voltage-gated sodium channel blocker and a TRPV1 agonist. Capsaicin is most often used as a topical analgesic. Capsaicin is a naturally-occurring botanical irritant in chili peppers (Capsicum pubescens, Capsicum annuum, Paprika) Hydrolysed by lipase B from Candida antarctica into vanillylamine and 8-methyl-6-trans-nonenoic acid
General
Type : Fatty acid ester, Natural, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Canonical SMILES : CC(C)\/C=C\/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI : InChI=1S\/C18H27NO3\/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3\/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)\/b8-6+
InChIKey : YKPUWZUDDOIDPM-SOFGYWHQSA-N
Other name(s) : Capsaicine || (E)-Capsaicin || Zostrix || CHEBI:3374 || CHEMBL294199 || SCHEMBL8085 || SCHEMBL8086
MW : 305.4
Formula : C18H27NO3
CAS_number : 404-86-4
PubChem : 1548943
UniChem : YKPUWZUDDOIDPM-SOFGYWHQSA-N
Target
Structures : No structure
Families : Canar_LipB
References (3)
| Title : The amidase activity of Candida antarctica lipase B is dependent on specific structural features of the substrates - Torres-Gavilan_2006_J.Mol.Catal.B.Enzym_41_136 |
| Author(s) : Torres-Gavilan A , Castillo E , Lopez-Munguia A |
| Ref : J Mol Catal B Enzym , 41 :136 , 2006 |
| Abstract : |
| PubMedSearch : Torres-Gavilan_2006_J.Mol.Catal.B.Enzym_41_136 |
| PubMedID: |
| Title : - Reyes-Duarte_2000_Biotechnol.Lett_22_1811 |
| Author(s) : Reyes-Duarte D , Castillo , Barzana E , Lopez-Munguia A |
| Ref : Biotechnol Lett , 22 :1811 , 2000 |
| Abstract : |
| PubMedSearch : Reyes-Duarte_2000_Biotechnol.Lett_22_1811 |
| PubMedID: |
| Title : Preparation of optically pure chiral amines by lipase -catalyzed enantioselective hydrolysis of N-acyl-amines - Smidt_1996_Biotechnol.Tech_10_335 |
| Author(s) : Smidt H , Fischer A , Fischer P , Schmid RD |
| Ref : Biotechnology Techniques , 10 :335 , 1996 |
| Abstract : |
| PubMedSearch : Smidt_1996_Biotechnol.Tech_10_335 |
| PubMedID: |
| Gene_locus related to this paper: canar-LipB |