Svensson_1998_Neuroreport_9_1519

Reference

Title : Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells - Svensson_1998_Neuroreport_9_1519
Author(s) : Svensson AL , Nordberg A
Ref : Neuroreport , 9 :1519 , 1998
Abstract : The effect of the cholinesterase inhibitors tacrine and donepezil on A beta(25-35)-induced toxicity was investigated in rat pheochromocytoma PC12 cells by measuring the mitochondrial activity. Tacrine and donepezil was found in clinical relevant concentrations (10(-7)-10(-6) M) to attenuate A beta(25-35)-induced toxicity in PC12 cells. The neuroprotective effect of tacrine was blocked in the presence of the nicotinic antagonists mecamylamine (10(-5) M) and tubocurarine (10(-5) M), suggesting an interaction via nicotinic receptors. This study demonstrates that tacrine and donepezil can exert neuroprotective properties which might be of importance and contribute to the clinical efficacy of cholinesterase inhibitors in the treatment of Alzheimer's disease.
ESTHER : Svensson_1998_Neuroreport_9_1519
PubMedSearch : Svensson_1998_Neuroreport_9_1519
PubMedID: 9631459

Related information

Citations formats

Svensson AL, Nordberg A (1998)
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells
Neuroreport 9 :1519

Svensson AL, Nordberg A (1998)
Neuroreport 9 :1519

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    [author] => Svensson AL || Nordberg A
    [year] => 1998
    [title] => Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells
    [journal] => Neuroreport
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    [page] => 1519
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            [content] => The effect of the cholinesterase inhibitors tacrine and donepezil on A beta(25-35)-induced toxicity was investigated in rat pheochromocytoma PC12 cells by measuring the mitochondrial activity. Tacrine and donepezil was found in clinical relevant concentrations (10(-7)-10(-6) M) to attenuate A beta(25-35)-induced toxicity in PC12 cells. The neuroprotective effect of tacrine was blocked in the presence of the nicotinic antagonists mecamylamine (10(-5) M) and tubocurarine (10(-5) M), suggesting an interaction via nicotinic receptors. This study demonstrates that tacrine and donepezil can exert neuroprotective properties which might be of importance and contribute to the clinical efficacy of cholinesterase inhibitors in the treatment of Alzheimer's disease.
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