Tacrine

Tacrine is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine therapy is associated with a very high rate of serum aminotransferase elevations during therapy and has been linked to several instances of clinically apparent, acute liver injury. || C13H14N2 * HCl MW 234.71 CAS 1684-40-8 || Treatment of Alzheimer Disease, trademark is cognex. Reversible inhibitor of both AChE and BChE Tacrine is an oral acetylcholinesterase inhibitor previously used for therapy of Alzheimer disease. Tacrine therapy is associated with a very high rate of serum aminotransferase elevations during therapy and has been linked to several instances of clinically apparent, acute liver injury. release of endogenous 5-hydroxytryptamine (5-HT) not through a cholinergic, reserpine- or amphetamine-like mechanism or through inhibition of reuptake. The release may occur via blockade of 4-AP-insensitive K+ channels

General

Type : Derivative of Tacrine, Acridine

Chemical_Nomenclature : 1,2,3,4-tetrahydroacridin-9-amine

Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)N

InChI : InChI=1S\/C13H14N2\/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13\/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

InChIKey : YLJREFDVOIBQDA-UHFFFAOYSA-N

Other name(s) : 1,2,3,4,-tetrahydro-9 aminoacridine  ||  Tetrahydroaminacrine  ||  Tetrahydroaminoacridine  ||  Cognex  ||  tetrahydroamino-acridine  ||  THA


MW : 198.27

Formula : C13H14N2

CAS_number : 321-64-2

PubChem : 1935

UniChem : YLJREFDVOIBQDA-UHFFFAOYSA-N

IUPHAR : 6687

Target

Families : Tacrine ligand of proteins in family
ACHE

Structure :
1ACJ 7XN1 4BDS 1MX1

Protein :
torca-ACHE human-BCHE human-CES1 human-ACHE

References (71)

Title : Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery - Dileep_2022_Int.J.Biol.Macromol_210_172
Author(s) : Dileep KV , Ihara K , Mishima-Tsumagari C , Kukimoto-Niino M , Yonemochi M , Hanada K , Shirouzu M , Zhang KYJ
Ref : Int J Biol Macromol , 210 :172 , 2022
Abstract :
PubMedSearch : Dileep_2022_Int.J.Biol.Macromol_210_172
PubMedID: 35526766
Gene_locus related to this paper: human-ACHE

Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226
Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM
Ref : Chemico-Biological Interactions , 203 :226 , 2013
Abstract :
PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226
PubMedID: 23123248

Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341
Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR
Ref : Chemical Biology , 10 :341 , 2003
Abstract :
PubMedSearch : Bencharit_2003_Chem.Biol_10_341
PubMedID: 12725862
Gene_locus related to this paper: human-CES1

Title : Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity - Alhomida_2000_Toxicology_147_33
Author(s) : Alhomida AS , Al-Rajhi AA , Kamal MA , Al-Jafari AA
Ref : Toxicology , 147 :33 , 2000
Abstract :
PubMedSearch : Alhomida_2000_Toxicology_147_33
PubMedID: 10837930

Title : Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease - Camps_2000_Mol.Pharmacol_57_409
Author(s) : Camps P , Cusack B , Mallender WD , Achab RE , Morral J , Munoz-Torrero D , Rosenberry TL
Ref : Molecular Pharmacology , 57 :409 , 2000
Abstract :
PubMedSearch : Camps_2000_Mol.Pharmacol_57_409
PubMedID: 10648652

Title : Mass psychogenic illness attributed to toxic exposure at a high school -
Author(s) : Heuser G
Ref : N Engl J Med , 342 :1674\; author reply 1675 , 2000
PubMedID: 10836879

Title : In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects - Traykov_1999_Eur.J.Neurol_6_273
Author(s) : Traykov L , Tavitian B , Jobert A , Boller F , Forette F , Crouzel C , Di Giamberardino L , Pappata S
Ref : Eur Journal of Neurology , 6 :273 , 1999
Abstract :
PubMedSearch : Traykov_1999_Eur.J.Neurol_6_273
PubMedID: 10210906

Title : Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents - Zhao_1999_Bioorg.Med.Chem_7_1637
Author(s) : Zhao S , Totleben MJ , Freeman JP , Bacon CL , Fox GB , O'Driscoll E , Foley AG , Kelly J , Farrell U , Regan C , Mizsak SA , Szmuszkovicz J
Ref : Bioorganic & Medicinal Chemistry , 7 :1637 , 1999
Abstract :
PubMedSearch : Zhao_1999_Bioorg.Med.Chem_7_1637
PubMedID: 10482456

Title : Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys - Callahan_1999_Psychopharmacology.(Berl)_144_234
Author(s) : Callahan MJ
Ref : Psychopharmacology (Berl) , 144 :234 , 1999
Abstract :
PubMedSearch : Callahan_1999_Psychopharmacology.(Berl)_144_234
PubMedID: 10435389

Title : Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications - Giacobini_1998_Neurochem.Int_32_413
Author(s) : Giacobini E
Ref : Neurochem Int , 32 :413 , 1998
Abstract :
PubMedSearch : Giacobini_1998_Neurochem.Int_32_413
PubMedID: 9676739

Title : Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease - Riekkinen_1998_Neurosci_83_471
Author(s) : Riekkinen M , Soininen H , Riekkinen P, Sr. , Kuikka J , Laakso M , Helkala EL , Partanen J , Riekkinen P, Jr.
Ref : Neuroscience , 83 :471 , 1998
Abstract :
PubMedSearch : Riekkinen_1998_Neurosci_83_471
PubMedID: 9460755

Title : Penetration of tacrine into cerebrospinal fluid in patients with Alzheimer's disease - Grothe_1998_J.Clin.Psychopharmacol_18_78
Author(s) : Grothe DR , Piscitelli SC , Dukoff R , Fullerton T , Sunderland T , Molchan SE
Ref : J Clin Psychopharmacol , 18 :78 , 1998
Abstract :
PubMedSearch : Grothe_1998_J.Clin.Psychopharmacol_18_78
PubMedID: 9472847

Title : Functional and subcellular organelle changes in isolated rat and human hepatocytes induced by tetrahydroaminoacridine - Monteith_1998_Arch.Toxicol_72_147
Author(s) : Monteith DK , Theiss JC , Haskins JR , de la Iglesia FA
Ref : Archives of Toxicology , 72 :147 , 1998
Abstract :
PubMedSearch : Monteith_1998_Arch.Toxicol_72_147
PubMedID: 9520138

Title : Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats - Meyer_1998_Brain.Res_786_252
Author(s) : Meyer EM , King MA , Meyers C
Ref : Brain Research , 786 :252 , 1998
Abstract :
PubMedSearch : Meyer_1998_Brain.Res_786_252
PubMedID: 9555043

Title : Sensitivity of bovine retinal acetylcholinesterase (E.C. 3.1.1.7) toward tacrine: kinetic characterization - al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245
Author(s) : Al-Jafari AA , Kamal MA , Alhomida AS
Ref : J Biochem Mol Toxicol , 12 :245 , 1998
Abstract :
PubMedSearch : al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245
PubMedID: 9580877

Title : Responses induced by tacrine in neuronal and non-neuronal cell lines - De Ferrari_1998_J.Neurosci.Res_52_435
Author(s) : De Ferrari GV , Von Bernhardi R , Calderon FH , Luza SC , Inestrosa NC
Ref : Journal of Neuroscience Research , 52 :435 , 1998
Abstract :
PubMedSearch : De Ferrari_1998_J.Neurosci.Res_52_435
PubMedID: 9589388

Title : Shuttle-box avoidance learning in mice: improvement by combined glucose and tacrine - Pavone_1998_Neurobiol.Learn.Mem_69_204
Author(s) : Pavone F , Capone F , Battaglia M , Sansone M
Ref : Neurobiol Learn Mem , 69 :204 , 1998
Abstract :
PubMedSearch : Pavone_1998_Neurobiol.Learn.Mem_69_204
PubMedID: 9619996

Title : Tetrahydroaminoacridine, a cholinesterase inhibitor, and D-cycloserine, a partial NMDA receptor-associated glycine site agonist, enhances acquisition of spatial navigation - Riekkinen_1998_Neuroreport_9_1633
Author(s) : Riekkinen P, Jr. , Ikonen S , Riekkinen M
Ref : Neuroreport , 9 :1633 , 1998
Abstract :
PubMedSearch : Riekkinen_1998_Neuroreport_9_1633
PubMedID: 9631478

Title : Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release - Allal_1998_Eur.J.Pharmacol_348_191
Author(s) : Allal C , Lazartigues E , Tran MA , Brefel-Courbon C , Gharib C , Montastruc JL , Rascol O
Ref : European Journal of Pharmacology , 348 :191 , 1998
Abstract :
PubMedSearch : Allal_1998_Eur.J.Pharmacol_348_191
PubMedID: 9652334

Title : Effects of AF102B and tacrine on delayed match-to-sample in monkeys - O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665
Author(s) : O'Neill J , Fitten LJ , Siembieda D , Halgren E , Kim E , Fisher A , Perryman K
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 22 :665 , 1998
Abstract :
PubMedSearch : O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665
PubMedID: 9682279

Title : Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats - Giovannini_1998_Eur.J.Pharmacol_354_17
Author(s) : Giovannini MG , Scali C , Bartolini L , Schmidt B , Pepeu G
Ref : European Journal of Pharmacology , 354 :17 , 1998
Abstract :
PubMedSearch : Giovannini_1998_Eur.J.Pharmacol_354_17
PubMedID: 9726626

Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427
Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM
Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998
Abstract :
PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427
PubMedID: 9597187

Title : Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities - Cheng_1998_Pharmacol.Biochem.Behav_60_377
Author(s) : Cheng DH , Tang XC
Ref : Pharmacol Biochem Behav , 60 :377 , 1998
Abstract :
PubMedSearch : Cheng_1998_Pharmacol.Biochem.Behav_60_377
PubMedID: 9632220

Title : Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells - Svensson_1998_Neuroreport_9_1519
Author(s) : Svensson AL , Nordberg A
Ref : Neuroreport , 9 :1519 , 1998
Abstract :
PubMedSearch : Svensson_1998_Neuroreport_9_1519
PubMedID: 9631459

Title : Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease - Costagli_1998_Biochem.Pharmacol_55_1733
Author(s) : Costagli C , Galli A
Ref : Biochemical Pharmacology , 55 :1733 , 1998
Abstract :
PubMedSearch : Costagli_1998_Biochem.Pharmacol_55_1733
PubMedID: 9634011

Title : Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine - Wang_1998_Eur.J.Pharmacol_349_137
Author(s) : Wang T , Tang XC
Ref : European Journal of Pharmacology , 349 :137 , 1998
Abstract :
PubMedSearch : Wang_1998_Eur.J.Pharmacol_349_137
PubMedID: 9671090

Title : Capillary zone electrophoretic determination of some drugs against Alzheimer's disease - Vargas_1998_J.Chromatogr.A_802_121
Author(s) : Vargas MG , Havel J , Patocka J
Ref : Journal of Chromatography A , 802 :121 , 1998
Abstract :
PubMedSearch : Vargas_1998_J.Chromatogr.A_802_121
PubMedID: 9588015

Title : Safety of tacrine: clinical trials, treatment IND, and postmarketing experience - Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93
Author(s) : Gracon SI , Knapp MJ , Berghoff WG , Pierce M , DeJong R , Lobbestael SJ , Symons J , Dombey SL , Luscombe FA , Kraemer D
Ref : Alzheimer Disease & Associated Disorders , 12 :93 , 1998
Abstract :
PubMedSearch : Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93
PubMedID: 9651138

Title : Alzheimer's disease: an overview for the pharmacist - McGuffey_1997_J.Am.Pharm.Assoc_3_347
Author(s) : McGuffey EC
Ref : J Am Pharm Assoc , 3 :347 , 1997
Abstract :
PubMedSearch : McGuffey_1997_J.Am.Pharm.Assoc_3_347
PubMedID: 9170813

Title : Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease - Riekkinen_1997_Neuroreport_8_1845
Author(s) : Riekkinen P, Jr. , Riekkinen M , Soininen H , Kuikka J , Laakso M , Riekkinen P, Sr.
Ref : Neuroreport , 8 :1845 , 1997
Abstract :
PubMedSearch : Riekkinen_1997_Neuroreport_8_1845
PubMedID: 9223063

Title : The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat - Ibebunjo_1997_Anesth.Analg_85_431
Author(s) : Ibebunjo C , Donati F , Fox GS , Eshelby D , Tchervenkov JI
Ref : Anesthesia & Analgesia , 85 :431 , 1997
Abstract :
PubMedSearch : Ibebunjo_1997_Anesth.Analg_85_431
PubMedID: 9249126

Title : Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs - Cousins_1997_Eur.J.Pharmacol_322_137
Author(s) : Cousins MS , Carriero DL , Salamone JD
Ref : European Journal of Pharmacology , 322 :137 , 1997
Abstract :
PubMedSearch : Cousins_1997_Eur.J.Pharmacol_322_137
PubMedID: 9098680

Title : The effect of several putative cognition enhancers on a water maze acquisition deficit produced by pCPA + scopolamine combination treatment - Harder_1997_Pharmacol.Biochem.Behav_56_657
Author(s) : Harder JA , Kelly ME
Ref : Pharmacol Biochem Behav , 56 :657 , 1997
Abstract :
PubMedSearch : Harder_1997_Pharmacol.Biochem.Behav_56_657
PubMedID: 9130291

Title : Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons - Pool_1997_Drug.Metab.Dispos_25_590
Author(s) : Pool WF , Reily MD , Bjorge SM , Woolf TF
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 25 :590 , 1997
Abstract :
PubMedSearch : Pool_1997_Drug.Metab.Dispos_25_590
PubMedID: 9152598

Title : Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) on ATP diphosphohydrolase (EC 3.6.1.5) and 5'-nucleotidase (EC 3.1.3.5) from rat brain synaptosomes - Bonan_1997_Gen.Pharmacol_28_761
Author(s) : Bonan CD , Battastini AM , Schetinger MR , Moreira CM , Frassetto SS , Dias RD , Sarkis JJ
Ref : General Pharmacology , 28 :761 , 1997
Abstract :
PubMedSearch : Bonan_1997_Gen.Pharmacol_28_761
PubMedID: 9184816

Title : Effect of tetrahydroaminoacridine, a cholinesterase inhibitor, on cognitive performance following experimental brain injury - Pike_1997_J.Neurotrauma_14_897
Author(s) : Pike BR , Hamm RJ , Temple MD , Buck DL , Lyeth BG
Ref : Journal of Neurotrauma , 14 :897 , 1997
Abstract :
PubMedSearch : Pike_1997_J.Neurotrauma_14_897
PubMedID: 9475371

Title : Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys - Rupniak_1997_Psychopharmacology_131_406
Author(s) : Rupniak NM , Tye SJ , Field MJ
Ref : Psychopharmacology , 131 :406 , 1997
Abstract :
PubMedSearch : Rupniak_1997_Psychopharmacology_131_406
PubMedID: 9226744

Title : Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia [published erratum appears in Methods Find Exp Clin Pharmacol 1997 Jun\;19(5):364] - Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245
Author(s) : Kojima J , Nakajima K , Ochiai M , Nakayama K
Ref : Methods Find Exp Clin Pharmacol , 19 :245 , 1997
Abstract :
PubMedSearch : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245
PubMedID: 9228650

Title : Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys - Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408
Author(s) : Tsukada H , Kakiuchi T , Ando I , Ouchi Y
Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :1408 , 1997
Abstract :
PubMedSearch : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408
PubMedID: 9190877

Title : Pharmacological basis of drug therapy of Alzheimer's disease - Sharma_1997_Indian.J.Exp.Biol_35_1146
Author(s) : Sharma A , Parikh V , Singh M
Ref : Indian J Exp Biol , 35 :1146 , 1997
Abstract :
PubMedSearch : Sharma_1997_Indian.J.Exp.Biol_35_1146
PubMedID: 9567741

Title : Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats - Jakala_1997_Pharmacol.Biochem.Behav_56_713
Author(s) : Jakala P , Riekkinen P, Jr.
Ref : Pharmacol Biochem Behav , 56 :713 , 1997
Abstract :
PubMedSearch : Jakala_1997_Pharmacol.Biochem.Behav_56_713
PubMedID: 9130298

Title : Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures - Lahiri_1997_Ann.N.Y.Acad.Sci_826_416
Author(s) : Lahiri DK , Farlow MR , Nurnberger JI, Jr. , Greig NH
Ref : Annals of the New York Academy of Sciences , 826 :416 , 1997
Abstract :
PubMedSearch : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416
PubMedID: 9329715

Title : Motor dysfunction produced by tacrine administration in rats - Carriero_1997_Pharmacol.Biochem.Behav_58_851
Author(s) : Carriero DL , Outslay G , Mayorga AJ , Aberman J , Gianutsos G , Salamone JD
Ref : Pharmacol Biochem Behav , 58 :851 , 1997
Abstract :
PubMedSearch : Carriero_1997_Pharmacol.Biochem.Behav_58_851
PubMedID: 9408186

Title : [Advantages in long-term treatment with Cognex in Alzheimer disease] - Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350
Author(s) : Gracon S , Smith F , Shokry A
Ref : Schweiz Rundsch Med Prax , 86 :1350 , 1997
Abstract :
PubMedSearch : Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350
PubMedID: 9381027

Title : Prevention of amitriptyline-induced avoidance impairment by tacrine in mice - Pavone_1997_Behav.Brain.Res_89_229
Author(s) : Pavone F , Battaglia M , Sansone M
Ref : Behavioural Brain Research , 89 :229 , 1997
Abstract :
PubMedSearch : Pavone_1997_Behav.Brain.Res_89_229
PubMedID: 9475630

Title : Studies on a new series of THA analogues: effects of the aromatic residues that line the gorge of AChE - Pomponi_1997_FEBS.Lett_409_155
Author(s) : Pomponi M , Marta M , Colella A , Sacchi S , Patamia M , Gatta F , Capone F , Oliverio A , Pavone F
Ref : FEBS Letters , 409 :155 , 1997
Abstract :
PubMedSearch : Pomponi_1997_FEBS.Lett_409_155
PubMedID: 9202137

Title : [Alzheimer disease cannot be treated with Cognex] -
Author(s) : Shafazand M
Ref : Lakartidningen , 93 :1406 , 1996
PubMedID: 8667714

Title : Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions - Jackson_1996_Life.Sci_58_47
Author(s) : Jackson JJ , Soliman MR
Ref : Life Sciences , 58 :47 , 1996
Abstract :
PubMedSearch : Jackson_1996_Life.Sci_58_47
PubMedID: 8628110

Title : Huperzine A, a novel promising acetylcholinesterase inhibitor - Cheng_1996_Neuroreport_8_97
Author(s) : Cheng DH , Ren H , Tang XC
Ref : Neuroreport , 8 :97 , 1996
Abstract :
PubMedSearch : Cheng_1996_Neuroreport_8_97
PubMedID: 9051760

Title : An enriched-population, double-blind, placebo-controlled, crossover study of tacrine and lecithin in Alzheimer's disease. The Tacrine 970-6 Study Group - Foster_1996_Dementia_7_260
Author(s) : Foster NL , Petersen RC , Gracon SI , Lewis K
Ref : Dementia , 7 :260 , 1996
Abstract :
PubMedSearch : Foster_1996_Dementia_7_260
PubMedID: 8872417

Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H
Ref : Molecular Pharmacology , 50 :1423 , 1996
Abstract :
PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
PubMedID: 8967962
Gene_locus related to this paper: human-BCHE

Title : Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors - Gnagey_1996_Biochem.Pharmacol_52_1767
Author(s) : Gnagey AL , Ellis J
Ref : Biochemical Pharmacology , 52 :1767 , 1996
Abstract :
PubMedSearch : Gnagey_1996_Biochem.Pharmacol_52_1767
PubMedID: 8986140

Title : The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations - Bezek_1996_Xenobiotica_26_935
Author(s) : Bezek S , Kukan M , Pool WF , Woolf TF
Ref : Xenobiotica , 26 :935 , 1996
Abstract :
PubMedSearch : Bezek_1996_Xenobiotica_26_935
PubMedID: 8893040

Title : Inhibition of tacrine oral clearance by cimetidine - Forgue_1996_Clin.Pharmacol.Ther_59_444
Author(s) : Forgue ST , Reece PA , Sedman AJ , deVries TM
Ref : Clinical Pharmacology & Therapeutics , 59 :444 , 1996
Abstract :
PubMedSearch : Forgue_1996_Clin.Pharmacol.Ther_59_444
PubMedID: 8612390

Title : [Pharma-clinics. Drug of the month. Tacrine (Cognex)] -
Author(s) : Scheen AJ
Ref : Rev Med Liege , 51 :379 , 1996
PubMedID: 8992561

Title : Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase - Pacheco_1995_J.Pharmacol.Exp.Ther_274_767
Author(s) : Pacheco G , Palacios-Esquivel R , Moss DE
Ref : Journal of Pharmacology & Experimental Therapeutics , 274 :767 , 1995
Abstract :
PubMedSearch : Pacheco_1995_J.Pharmacol.Exp.Ther_274_767
PubMedID: 7636741

Title : Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library - Pirrung_1995_Chem.Biol_2_621
Author(s) : Pirrung MC , Chau JH , Chen J
Ref : Chemistry & Biology , 2 :621 , 1995
Abstract :
PubMedSearch : Pirrung_1995_Chem.Biol_2_621
PubMedID: 9383467

Title : [New therapeutic prospects in Alzheimer disease] - Rouhart_1995_Rev.Med.Interne_16_860
Author(s) : Rouhart F
Ref : Rev Med Interne , 16 :860 , 1995
Abstract :
PubMedSearch : Rouhart_1995_Rev.Med.Interne_16_860
PubMedID: 8570945

Title : MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice - Murai_1994_J.Neur.Transm_98_1
Author(s) : Murai S , Saito H , Abe E , Masuda Y , Odashima J , Itoh T
Ref : Journal of Neural Transmission General Section , 98 :1 , 1994
Abstract :
PubMedSearch : Murai_1994_J.Neur.Transm_98_1
PubMedID: 7710736

Title : Changes of rat blood and tissue cholinesterases following administration of tacrine derivatives in vivo - Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73
Author(s) : Bajgar J , Skopec F
Ref : Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity , 36 :73 , 1993
Abstract :
PubMedSearch : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73
PubMedID: 8165433

Title : The next generation of cholinesterase inhibitors - Adem_1993_Acta.Neurol.Scand.Suppl_149_10
Author(s) : Adem A
Ref : Acta Neurologica Scandinavica Supplementum , 149 :10 , 1993
Abstract :
PubMedSearch : Adem_1993_Acta.Neurol.Scand.Suppl_149_10
PubMedID: 8128831

Title : Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase - Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
Author(s) : Harel M , Schalk I , Ehret-Sabatier L , Bouet F , Goeldner M , Hirth C , Axelsen PH , Silman I , Sussman JL
Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :9031 , 1993
Abstract :
PubMedSearch : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
PubMedID: 8415649
Gene_locus related to this paper: torca-ACHE

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