Swale_2015_Pest.Manag.Sci_71_1158

Reference

Title : Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management - Swale_2015_Pest.Manag.Sci_71_1158
Author(s) : Swale DR , Carlier PR , Hartsel JA , Ma M , Bloomquist JR
Ref : Pest Manag Sci , 71 :1158 , 2015
Abstract :

BACKGROUND: Insecticide resistance in the malaria mosquito Anopheles gambiae is well documented, and widespread agricultural use of pyrethroids may exacerbate development of resistance when pyrethroids are used in vector control. We have developed carbamate anticholinesterases that possess a high degree of An. gambiae:human selectivity for enzyme inhibition. The purpose of this study was to assess the spectrum of activity of these carbamates against other mosquitoes and agricultural pests.
RESULTS: Experimental carbamates were potent inhibitors of mosquito acetylcholinesterases, with IC50 values in the nanomolar range. Similar potencies were observed for Musca domestica and Drosophila melanogaster enzymes. Although meta-substituted carbamates were potent inhibitors, two ortho-substituted carbamates displayed poor enzyme inhibition (IC50 >/= 10(-6) M) in honey bee (Apis mellifera), Asian citrus psyllid (Diaphorina citri) and lepidopteran agricultural pests (Plutella xylostella and Ostrinia nubilalis). Enzyme inhibition results were confirmed by toxicity studies in caterpillars, where the new carbamates were 2-3-fold less toxic than propoxur and up to tenfold less active than bendiocarb, indicating little utility of these compounds for crop protection. CONCLUSION: The experimental carbamates were broadly active against mosquito species but not agricultural pests, which should mitigate selection for mosquito insecticide resistance by reducing agricultural uses of these compounds. (c) 2014 Society of Chemical Industry.

PubMedSearch : Swale_2015_Pest.Manag.Sci_71_1158
PubMedID: 25185896
Gene_locus related to this paper: anoga-ACHE1

Related information

Gene_locus anoga-ACHE1

Citations formats

Swale DR, Carlier PR, Hartsel JA, Ma M, Bloomquist JR (2015)
Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management
Pest Manag Sci 71 :1158

Swale DR, Carlier PR, Hartsel JA, Ma M, Bloomquist JR (2015)
Pest Manag Sci 71 :1158