Tan_2025_Int.J.Oncol_66_20

Long non-coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11-AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, reverse transcription-quantitative PCR and in situ hybridization revealed that ABHD11-AS1 expression was decreased in CRC samples and associated with an unfavorable prognosis. ABHD11-AS1 overexpression significantly decreased proliferation, migration and invasion of CRC cells, whereas ABHD11-AS1 inhibition had the opposite effects. ABHD11-AS1 interacted with EGFR to inhibit EGFR phosphorylation and attenuate EGFR/ERK signaling, which in turn suppressed the malignant biological behavior of CRC cells. The tumor suppressor function of ABHD11-AS1 was attenuated by the EGFR agonist NSC228155. Finally, resveratrol (RSV) inhibited CRC cell proliferation, migration and invasion, which may be associated with RSV-induced decrease in SPT6 homolog, histone chaperone and transcription elongation factor protein expression and increase in ABHD11-AS1 transcript levels. ABHD11-AS1 inhibited the phosphorylation of EGFR and decreased EGFR/ERK signaling by interacting with EGFR, thereby delaying the progression of CRC. The ABHD11-AS1/EGFR/ERK axis may be a novel therapeutic target for preventing CRC progression.