ABHD11-Acetyl_transferase

Relationship

Family: ABHD11-Acetyl_transferase

Block: X

Parent Family: Abhydrolase_6

Comment

ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al. published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (3)

Genes Proteins in ABHD11-Acetyl_transferase family (423)

Fragments of genes in ABHD11-Acetyl_transferase family (31)

Structures in ABHD11-Acetyl_transferase family (3)

Substrates in ABHD11-Acetyl_transferase family (7)

Inhibitors in ABHD11-Acetyl_transferase family (6)

References (14)

Title : ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies - Golla_2022_Noncoding.RNA_8_21
Author(s) : Golla U , Sesham K , Dallavalasa S , Manda NK , Unnam S , Sanapala AK , Nalla S , Kondam S , Kumar R
Ref : Noncoding RNA , 8 : , 2022
PubMedID: 35314614
Gene_locus related to this paper: human-ABHD11

Title : ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex - Bailey_2020_Nat.Commun_11_4046
Author(s) : Bailey PSJ , Ortmann BM , Martinelli AW , Houghton JW , Costa ASH , Burr SP , Antrobus R , Frezza C , Nathan JA
Ref : Nat Commun , 11 :4046 , 2020
PubMedID: 32792488
Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11

Title : ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis - Liu_2020_Front.Cell.Dev.Biol_8_570
Author(s) : Liu G , Ruan Y , Zhang J , Wang X , Wu W , He P , Wang J , Xiong J , Cheng Y , Liu L , Yang Y , Tian Y , Jian R
Ref : Front Cell Developmental Biology , 8 :570 , 2020
PubMedID: 32733886
Gene_locus related to this paper: human-ABHD11

Title : Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice - Park_2019_Neurosci.Res_147_58
Author(s) : Park H , Miyazaki H , Yamanaka T , Nukina N
Ref : Neurosci Res , 147 :58 , 2019
PubMedID: 30391555
Gene_locus related to this paper: human-ABHD11

Title : Ethyl acetate production by the elusive alcohol acetyltransferase from yeast - Kruis_2017_Metab.Eng_41_92
Author(s) : Kruis AJ , Levisson M , Mars AE , Van der Ploeg M , Garces Daza F , Ellena V , Kengen SWM , Van der Oost J , Weusthuis RA
Ref : Metab Eng , 41 :92 , 2017
PubMedID: 28356220
Gene_locus related to this paper: wicao-a0a1e3p8s6 , wiccf-k0kpv8 , wicao-a0a1e3p8s8 , wiccf-k0ksn3 , cybfa-a0a061ayy2

Title : Human alpha beta hydrolase domain containing protein 11 and its yeast homolog are lipid hydrolases - Arya_2017_Biochem.Biophys.Res.Commun_487_875
Author(s) : Arya M , Srinivasan M , Rajasekharan R
Ref : Biochemical & Biophysical Research Communications , 487 :875 , 2017
PubMedID: 28465236
Gene_locus related to this paper: human-ABHD11

Title : Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer - Chen_2017_Oncotarget_8_28176
Author(s) : Chen M , Li J , Zhuang C , Cai Z
Ref : Oncotarget , 8 :28176 , 2017
PubMedID: 28157695
Gene_locus related to this paper: human-ABHD11

Title : The Arabidopsis ABHD11 Mutant Accumulates Polar Lipids in Leaves as a Consequence of Absent Acylhydrolase Activity - Vijayakumar_2016_Plant.Physiol_170_180
Author(s) : Vijayakumar A , Vijayaraj P , Vijayakumar AK , Rajasekharan R
Ref : Plant Physiol , 170 :180 , 2016
PubMedID: 26589672
Gene_locus related to this paper: arath-AT4G10030

Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253
Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR
Ref : Eur J Pharm Sci , 93 :253 , 2016
PubMedID: 27544863
Gene_locus related to this paper: human-ABHD11

Title : Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer - Yang_2016_Tumour.Biol_37_1183
Author(s) : Yang Y , Shao Y , Zhu M , Li Q , Yang F , Lu X , Xu C , Xiao B , Sun Y , Guo J
Ref : Tumour Biol , 37 :1183 , 2016
PubMedID: 26280398
Gene_locus related to this paper: human-ABHD11

Title : Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo - Francelle_2015_Neurobiol.Aging_36_1601.e7
Author(s) : Francelle L , Galvan L , Gaillard MC , Petit F , Bernay B , Guillermier M , Bonvento G , Dufour N , Elalouf JM , Hantraye P , Deglon N , de Chaldee M , Brouillet E
Ref : Neurobiology of Aging , 36 :1601 e7 , 2015
PubMedID: 25619660
Gene_locus related to this paper: human-ABHD11

Title : Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance - Lin_2014_Med.Oncol_31_42
Author(s) : Lin X , Yang M , Xia T , Guo J
Ref : Med Oncol , 31 :42 , 2014
PubMedID: 24984296
Gene_locus related to this paper: human-ABHD11

Title : Activity-based proteomics: identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma - Wiedl_2011_J.Proteomics_74_1884
Author(s) : Wiedl T , Arni S , Roschitzki B , Grossmann J , Collaud S , Soltermann A , Hillinger S , Aebersold R , Weder W
Ref : J Proteomics , 74 :1884 , 2011
PubMedID: 21596165

Title : High-resolution structure of ybfF from Escherichia coli K12: a unique substrate-binding crevice generated by domain arrangement. - Park_2008_J.Mol.Biol_376_1426
Author(s) : Park SY , Lee SH , Lee J , Nishi K , Kim YS , Jung CH , Kim JS
Ref : Journal of Molecular Biology , 376 :1426 , 2008
PubMedID: 18215690
Gene_locus related to this paper: ecoli-ybff