human-ABHD11

Homo sapiens (Human) (EC 3.3.2.3) Abhydrolase domain-containing protein 11 williams-beuren syndrome critical region protein 21

Comment

No amidase\/protease, phosphatase, sulfatase, phospholipase C or phosphodiesterase activity. No activity of hABHD11 towards mono- or diacylglycerols. ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al.<\/A> published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies

Relationship

Family : ABHD11-Acetyl_transferase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Sequence

Peptide

MRAGQQLASM LRWTRAWRLP REGLGPHGPS FARVPVAPSS SSGGRGGAEP RLLDGEAALP AVVFLHGLFG SKTNFNSIAK ILAQQTGRRV LTVDARNHGD SPHSPDMSYE IMSQDLQDLL PQLGLVPCVV VGHSMGGKTA MLLALQRPEL VERLIAVDIS PVESTGVSHF ATYVAAMRAI NIADELPRSR ARKLADEQLS SVIQDMAVRQ HLLTNLVEVD GRFVWRVNLD ALTQHLDKIL AFPQRQESYL GPTLFLLGGN SQFVHPSHHP EIMRLFPRAQ MQTVPNAGHW IHADRPQDFI AAIRGFLV

References (34)

Title : LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1\/EGFR signaling pathway - Lu_2022_Clin.Transl.Oncol_24_1124
Author(s) : Lu H , Zhu C , Chen Y , Ruan Y , Fan L , Chen Q , Wei Q
Ref : Clin Transl Oncol , 24 :1124 , 2022
PubMedID: 35098448
Gene_locus related to this paper: human-ABHD11

Title : Pancreatic Cancer Cell-Derived Exosomes Promote Lymphangiogenesis by Downregulating ABHD11-AS1 Expression - Zhou_2022_Cancers.(Basel)_14_
Author(s) : Zhou X , Zhong F , Yan Y , Wu S , Wang H , Liu J , Li F , Cui D , Xu M
Ref : Cancers (Basel) , 14 : , 2022
PubMedID: 36230535
Gene_locus related to this paper: human-ABHD11

Title : LncRNA ABHD11-AS1 Participates in the Progression of Cervical Carcinoma by Targeting miR-1254 and Is the Key to the Diagnosis and Treatment of Cervical Carcinoma in the Future - Zhu_2022_J.Healthc.Eng_2022_8387458
Author(s) : Zhu D , Hao Q , Qian M , Hu Y , Wu F
Ref : J Healthc Eng , 2022 :8387458 , 2022
PubMedID: 35186240
Gene_locus related to this paper: human-ABHD11

Title : ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies - Golla_2022_Noncoding.RNA_8_21
Author(s) : Golla U , Sesham K , Dallavalasa S , Manda NK , Unnam S , Sanapala AK , Nalla S , Kondam S , Kumar R
Ref : Noncoding RNA , 8 : , 2022
PubMedID: 35314614
Gene_locus related to this paper: human-ABHD11

Title : A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes - Karottki_2021_Metab.Eng_66_114
Author(s) : Karottki KJC , Hefzi H , Li S , Pedersen LE , Spahn PN , Joshi C , Ruckerbauer D , Bort JAH , Thomas A , Lee JS , Borth N , Lee GM , Kildegaard HF , Lewis NE
Ref : Metab Eng , 66 :114 , 2021
PubMedID: 33813034
Gene_locus related to this paper: human-ABHD11

Title : Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5\/focal adhesion kinase\/phosphoinositide 3 kinase\/Akt signaling pathway - Luo_2021_Aging.(Albany.NY)_13_20179
Author(s) : Luo J , Jiang Y , Wu L , Zhuo D , Zhang S , Jiang X , Sun Y , Huang Y
Ref : Aging (Albany NY) , 13 :20179 , 2021
PubMedID: 34375304
Gene_locus related to this paper: human-ABHD11

Title : Single-Nucleotide Polymorphisms Promote Dysregulation Activation by Essential Gene Mediated Bio-Molecular Interaction in Breast Cancer - Wang_2021_Front.Oncol_11_791943
Author(s) : Wang X , Zhao Z , Han X , Zhang Y , Li F , Li H
Ref : Front Oncol , 11 :791943 , 2021
PubMedID: 34926308
Gene_locus related to this paper: human-ABHD11

Title : m(6) A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer - Xue_2021_J.Cell.Physiol_236_2649
Author(s) : Xue L , Li J , Lin Y , Liu D , Yang Q , Jian J , Peng J
Ref : Journal of Cellular Physiology , 236 :2649 , 2021
PubMedID: 32892348
Gene_locus related to this paper: human-ABHD11

Title : EZH2-mediated lncRNA ABHD11-AS1 promoter regulates the progression of ovarian cancer by targeting miR-133a-3p - Zhang_2021_Anticancer.Drugs_32_269
Author(s) : Zhang W , Huang X , Shi J
Ref : Anticancer Drugs , 32 :269 , 2021
PubMedID: 33491971
Gene_locus related to this paper: human-ABHD11

Title : Long non-coding RNA ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p\/PDPK1 signalling - Xin_2020_J.Biochem_168_465
Author(s) : Xin H , Yan Z , Cao J
Ref : J Biochem , 168 :465 , 2020
PubMedID: 32678870
Gene_locus related to this paper: human-ABHD11

Title : ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex - Bailey_2020_Nat.Commun_11_4046
Author(s) : Bailey PSJ , Ortmann BM , Martinelli AW , Houghton JW , Costa ASH , Burr SP , Antrobus R , Frezza C , Nathan JA
Ref : Nat Commun , 11 :4046 , 2020
PubMedID: 32792488
Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11

Title : ABHD11, a new diacylglycerol lipase involved in weight gain regulation - Escoubet_2020_PLoS.One_15_e0234780
Author(s) : Escoubet J , Kenigsberg M , Derock M , Yaligara V , Bock MD , Roche S , Massey F , de Foucauld H , Bettembourg C , Olivier A , Berthemy A , Capdevielle J , Legoux R , Perret E , Buzy A , Chardenot P , Destelle V , Leroy A , Cahours C , Teixeira S , Juvet P , Gauthier P , Leguet M , Rocheteau-Beaujouan L , Chatoux MA , Deshayes W , Clement M , Kabiri M , Orsini C , Mikol V , Didier M , Guillemot JC
Ref : PLoS ONE , 15 :e0234780 , 2020
PubMedID: 32579589
Gene_locus related to this paper: human-ABHD11

Title : ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis - Liu_2020_Front.Cell.Dev.Biol_8_570
Author(s) : Liu G , Ruan Y , Zhang J , Wang X , Wu W , He P , Wang J , Xiong J , Cheng Y , Liu L , Yang Y , Tian Y , Jian R
Ref : Front Cell Developmental Biology , 8 :570 , 2020
PubMedID: 32733886
Gene_locus related to this paper: human-ABHD11

Title : Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice - Park_2019_Neurosci.Res_147_58
Author(s) : Park H , Miyazaki H , Yamanaka T , Nukina N
Ref : Neurosci Res , 147 :58 , 2019
PubMedID: 30391555
Gene_locus related to this paper: human-ABHD11

Title : Circulating lncRNA ABHD11-AS1 serves as a biomarker for early pancreatic cancer diagnosis - Liu_2019_J.Cancer_10_3746
Author(s) : Liu Y , Feng W , Liu W , Kong X , Li L , He J , Wang D , Zhang M , Zhou G , Xu W , Chen W , Gong A , Xu M
Ref : J Cancer , 10 :3746 , 2019
PubMedID: 31333792
Gene_locus related to this paper: human-ABHD11

Title : STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p\/STAT3 axis and PI3K\/AKT signalling pathway - Wen_2019_Cell.Prolif_52_e12569
Author(s) : Wen J , Wang H , Dong T , Gan P , Fang H , Wu S , Li J , Zhang Y , Du R , Zhu Q
Ref : Cell Prolif , 52 :e12569 , 2019
PubMedID: 30657221
Gene_locus related to this paper: human-ABHD11

Title : lncRNA ABHD11-AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2 - Zeng_2019_Cancer.Med_8_7074
Author(s) : Zeng XY , Jiang XY , Yong JH , Xie H , Yuan J , Zeng D , Dou YY , Xiao SS
Ref : Cancer Med , 8 :7074 , 2019
PubMedID: 31568657
Gene_locus related to this paper: human-ABHD11

Title : Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p\/SLC1A5 axis - Zhuang_2019_Cell.Death.Dis_10_620
Author(s) : Zhuang X , Tong H , Ding Y , Wu L , Cai J , Si Y , Zhang H , Shen M
Ref : Cell Death Dis , 10 :620 , 2019
PubMedID: 31409775
Gene_locus related to this paper: human-ABHD11

Title : Long noncoding RNA ABHD11-AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR-1254-WNT11 pathway - He_2019_J.Cell.Physiol_234_12070
Author(s) : He D , Yue Z , Liu L , Fang X , Chen L , Han H
Ref : Journal of Cellular Physiology , 234 :12070 , 2019
PubMedID: 30537177
Gene_locus related to this paper: human-ABHD11

Title : Long non-coding RNA ABHD11-AS1 promotes colorectal cancer development through regulation of miR-133a\/SOX4 axis - Lei_2018_Biosci.Rep_38_
Author(s) : Lei X , Li L , Duan X
Ref : Bioscience Reports , 38 : , 2018
PubMedID: 30429229
Gene_locus related to this paper: human-ABHD11

Title : LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1 - Liu_2018_J.Cell.Mol.Med_22_3955
Author(s) : Liu Y , Wang LL , Chen S , Zong ZH , Guan X , Zhao Y
Ref : J Cell Mol Med , 22 :3955 , 2018
PubMedID: 29799152
Gene_locus related to this paper: human-ABHD11

Title : Long noncoding RNA ABHD11-AS1 predicts the prognosis of pancreatic cancer patients and serves as a promoter by activating the PI3K-AKT pathway - Qiao_2018_Eur.Rev.Med.Pharmacol.Sci_22_8630
Author(s) : Qiao X , Lv SX , Qiao Y , Li QP , Ye B , Wang CC , Miao L
Ref : Eur Rev Med Pharmacol Sci , 22 :8630 , 2018
PubMedID: 30575903
Gene_locus related to this paper: human-ABHD11

Title : Role of the lncRNA ABHD11-AS(1) in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC - Wu_2017_Mol.Cancer_16_138
Author(s) : Wu DD , Chen X , Sun KX , Wang LL , Chen S , Zhao Y
Ref : Mol Cancer , 16 :138 , 2017
PubMedID: 28818073
Gene_locus related to this paper: human-ABHD11

Title : Human alpha beta hydrolase domain containing protein 11 and its yeast homolog are lipid hydrolases - Arya_2017_Biochem.Biophys.Res.Commun_487_875
Author(s) : Arya M , Srinivasan M , Rajasekharan R
Ref : Biochemical & Biophysical Research Communications , 487 :875 , 2017
PubMedID: 28465236
Gene_locus related to this paper: human-ABHD11

Title : Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer - Chen_2017_Oncotarget_8_28176
Author(s) : Chen M , Li J , Zhuang C , Cai Z
Ref : Oncotarget , 8 :28176 , 2017
PubMedID: 28157695
Gene_locus related to this paper: human-ABHD11

Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253
Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR
Ref : Eur J Pharm Sci , 93 :253 , 2016
PubMedID: 27544863
Gene_locus related to this paper: human-ABHD11

Title : Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer - Yang_2016_Tumour.Biol_37_1183
Author(s) : Yang Y , Shao Y , Zhu M , Li Q , Yang F , Lu X , Xu C , Xiao B , Sun Y , Guo J
Ref : Tumour Biol , 37 :1183 , 2016
PubMedID: 26280398
Gene_locus related to this paper: human-ABHD11

Title : Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo - Francelle_2015_Neurobiol.Aging_36_1601.e7
Author(s) : Francelle L , Galvan L , Gaillard MC , Petit F , Bernay B , Guillermier M , Bonvento G , Dufour N , Elalouf JM , Hantraye P , Deglon N , de Chaldee M , Brouillet E
Ref : Neurobiology of Aging , 36 :1601 e7 , 2015
PubMedID: 25619660
Gene_locus related to this paper: human-ABHD11

Title : Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance - Lin_2014_Med.Oncol_31_42
Author(s) : Lin X , Yang M , Xia T , Guo J
Ref : Med Oncol , 31 :42 , 2014
PubMedID: 24984296
Gene_locus related to this paper: human-ABHD11

Title : Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes - Bachovchin_2009_Nat.Biotechnol_27_387
Author(s) : Bachovchin DA , Brown SJ , Rosen H , Cravatt BF
Ref : Nat Biotechnol , 27 :387 , 2009
PubMedID: 19329999
Gene_locus related to this paper: human-ABHD11

Title : Effects of rosiglitazone and high fat diet on lipase\/esterase expression in adipose tissue - Shen_2007_Biochim.Biophys.Acta_1771_177
Author(s) : Shen WJ , Patel S , Yu Z , Jue D , Kraemer FB
Ref : Biochimica & Biophysica Acta , 1771 :177 , 2007
PubMedID: 17215164
Gene_locus related to this paper: human-ABHD11

Title : The DNA sequence of human chromosome 7 - Hillier_2003_Nature_424_157
Author(s) : Hillier LW , Fulton RS , Fulton LA , Graves TA , Pepin KH , Wagner-McPherson C , Layman D , Maas J , Jaeger S , Walker R , Wylie K , Sekhon M , Becker MC , O'Laughlin MD , Schaller ME , Fewell GA , Delehaunty KD , Miner TL , Nash WE , Cordes M , Du H , Sun H , Edwards J , Bradshaw-Cordum H , Ali J , Andrews S , Isak A , Vanbrunt A , Nguyen C , Du F , Lamar B , Courtney L , Kalicki J , Ozersky P , Bielicki L , Scott K , Holmes A , Harkins R , Harris A , Strong CM , Hou S , Tomlinson C , Dauphin-Kohlberg S , Kozlowicz-Reilly A , Leonard S , Rohlfing T , Rock SM , Tin-Wollam AM , Abbott A , Minx P , Maupin R , Strowmatt C , Latreille P , Miller N , Johnson D , Murray J , Woessner JP , Wendl MC , Yang SP , Schultz BR , Wallis JW , Spieth J , Bieri TA , Nelson JO , Berkowicz N , Wohldmann PE , Cook LL , Hickenbotham MT , Eldred J , Williams D , Bedell JA , Mardis ER , Clifton SW , Chissoe SL , Marra MA , Raymond C , Haugen E , Gillett W , Zhou Y , James R , Phelps K , Iadanoto S , Bubb K , Simms E , Levy R , Clendenning J , Kaul R , Kent WJ , Furey TS , Baertsch RA , Brent MR , Keibler E , Flicek P , Bork P , Suyama M , Bailey JA , Portnoy ME , Torrents D , Chinwalla AT , Gish WR , Eddy SR , McPherson JD , Olson MV , Eichler EE , Green ED , Waterston RH , Wilson RK
Ref : Nature , 424 :157 , 2003
PubMedID: 12853948
Gene_locus related to this paper: human-ABHD11 , human-ACHE , human-CPVL , human-DPP6 , human-MEST

Title : Identification of additional transcripts in the Williams-Beuren syndrome critical region - Merla_2002_Hum.Genet_110_429
Author(s) : Merla G , Ucla C , Guipponi M , Reymond A
Ref : Hum Genet , 110 :429 , 2002
PubMedID: 12073013
Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21