| Title : Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase - Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| Author(s) : Tarver JE, Jr. , Pabba PK , Barbosa J , Han Q , Gardyan MW , Brommage R , Thompson AY , Schmidt JM , Wilson AG , He W , Lombardo VK , Carson KG , Wilson AGE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1525 , 2016 |
|
Abstract :
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified. |
| PubMedSearch : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| PubMedID: 26897593 |
| Gene_locus related to this paper: human-NOTUM |
| Inhibitor | M9N LP-922056 |
| Substrate | OPTS |
| Gene_locus | human-NOTUM |
| Family | Pectinacetylesterase-Notum |
Tarver JE, Jr., Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AG, He W, Lombardo VK, Carson KG, Wilson AGE (2016)
Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
Bioorganic & Medicinal Chemistry Lett
26 :1525
Tarver JE, Jr., Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AG, He W, Lombardo VK, Carson KG, Wilson AGE (2016)
Bioorganic & Medicinal Chemistry Lett
26 :1525