| Title : Contemporary paradigms for cholinergic ligand design guided by biological structure - Taylor_2004_Bioorg.Med.Chem.Lett_14_1875 |
| Author(s) : Taylor P , Hansen SB , Talley TT , Hibbs RE , Radic Z |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1875 , 2004 |
|
Abstract :
The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission. |
| PubMedSearch : Taylor_2004_Bioorg.Med.Chem.Lett_14_1875 |
| PubMedID: 15050619 |
Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z (2004)
Contemporary paradigms for cholinergic ligand design guided by biological structure
Bioorganic & Medicinal Chemistry Lett
14 :1875
Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z (2004)
Bioorganic & Medicinal Chemistry Lett
14 :1875