Title : Alpha-conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins - Tsetlin_2006_J.Mol.Neurosci_30_77 |
Author(s) : Tsetlin VI , Kasheverov IE , Zhmak MN , Utkin YN , Vulfius CA , Smit AB , Bertrand D |
Ref : Journal of Molecular Neuroscience , 30 :77 , 2006 |
Abstract :
Alpha-conotoxins, neurotoxic peptides from poisonous Conus marine snails, can be subdivided into several groups targeting distinct subtypes of nicotinic acetylcholine receptors (nAChRs). Such alpha-conotoxins as, for example, GI, MI, or SIA potently block muscle-type nAChRs from muscles and from the electric organ of Torpedo ray, whereas others target distinct neuronal nAChRs: alpha-conotoxins ImI and PnIB block pentaoligomeric alpha7 nAChRs, and alpha-conotoxins MII or PnIA inhibit heteromeric nAChRs made of combinations of alpha3 or alpha6 subunits with beta2 subunit. alpha-Conotoxins interact with N-terminal extracellular ligand-binding domains of nAChRs and are indispensable tools for distinguishing various subtypes of AChRs at normal and pathological states. Although many alpha-conotoxins have been isolated from Conus venoms, there is still a great need in more potent and selective tools, which in principle can be obtained by design and synthesis of novel alpha-conotoxin analogs. |
PubMedSearch : Tsetlin_2006_J.Mol.Neurosci_30_77 |
PubMedID: 17192636 |
Tsetlin VI, Kasheverov IE, Zhmak MN, Utkin YN, Vulfius CA, Smit AB, Bertrand D (2006)
Alpha-conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins
Journal of Molecular Neuroscience
30 :77
Tsetlin VI, Kasheverov IE, Zhmak MN, Utkin YN, Vulfius CA, Smit AB, Bertrand D (2006)
Journal of Molecular Neuroscience
30 :77