| Title : Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol - Varoli_2003_Farmaco_58_651 |
| Author(s) : Varoli L , Angeli P , Buccioni M , Burnelli S , Cavalli A , Marucci G , Recanatini M |
| Ref : Farmaco , 58 :651 , 2003 |
|
Abstract :
A series of new derivatives, related to diphenidol and to its 2-carbonyl analogue, were designed as antimuscarinic agents. The synthesized compounds were evaluated both as hydrochlorides and as methiodides by functional tests at guinea-pig heart (M(2)), guinea-pig ileum (M(3)) and rabbit vas deferens (putative M(4)). Two derivatives (3a and 5a) showed an M(3)-selective profile similar to that of the reference compounds, though they resulted less potent. |
| PubMedSearch : Varoli_2003_Farmaco_58_651 |
| PubMedID: 13679157 |
Varoli L, Angeli P, Buccioni M, Burnelli S, Cavalli A, Marucci G, Recanatini M (2003)
Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol
Farmaco
58 :651
Varoli L, Angeli P, Buccioni M, Burnelli S, Cavalli A, Marucci G, Recanatini M (2003)
Farmaco
58 :651