| Title : Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties - Basagni_2023_Eur.J.Med.Chem_261_115803 |
| Author(s) : Basagni F , Ortega JA , Bertozzi SM , Armirotti A , Summa M , Bertorelli R , Bartolini M , Mellor IR , Bedeschi M , Bottegoni G , Lembo V , Minarini A , Cavalli A , Rosini M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115803 , 2023 |
| Abstract : |
| PubMedSearch : Basagni_2023_Eur.J.Med.Chem_261_115803 |
| PubMedID: 37734258 |
| Title : Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140-A Multitarget Compound for Alzheimer's Disease - Singhal_2019_Mol.Pharm_16_3460 |
| Author(s) : Singhal M , Merino V , Rosini M , Cavalli A , Kalia YN |
| Ref : Mol Pharm , 16 :3460 , 2019 |
| Abstract : |
| PubMedSearch : Singhal_2019_Mol.Pharm_16_3460 |
| PubMedID: 31241959 |
| Title : Chalcone-based carbamates for Alzheimer's disease treatment - Rampa_2017_Future.Med.Chem_9_749 |
| Author(s) : Rampa A , Montanari S , Pruccoli L , Bartolini M , Falchi F , Feoli A , Cavalli A , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Future Med Chem , 9 :749 , 2017 |
| Abstract : |
| PubMedSearch : Rampa_2017_Future.Med.Chem_9_749 |
| PubMedID: 28498775 |
| Title : Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation - Simoni_2017_Future.Med.Chem_9_953 |
| Author(s) : Simoni E , Bartolini M , Abu IF , Blockley A , Gotti C , Bottegoni G , Caporaso R , Bergamini C , Andrisano V , Cavalli A , Mellor IR , Minarini A , Rosini M |
| Ref : Future Med Chem , 9 :953 , 2017 |
| Abstract : |
| PubMedSearch : Simoni_2017_Future.Med.Chem_9_953 |
| PubMedID: 28632446 |
| Title : In Vivo Characterization of ARN14140, a Memantine\/Galantamine-Based Multi-Target Compound for Alzheimer's Disease - Reggiani_2016_Sci.Rep_6_33172 |
| Author(s) : Reggiani AM , Simoni E , Caporaso R , Meunier J , Keller E , Maurice T , Minarini A , Rosini M , Cavalli A |
| Ref : Sci Rep , 6 :33172 , 2016 |
| Abstract : |
| PubMedSearch : Reggiani_2016_Sci.Rep_6_33172 |
| PubMedID: 27609215 |
| Title : Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives - Montanari_2016_ChemMedChem_11_1296 |
| Author(s) : Montanari S , Bartolini M , Neviani P , Belluti F , Gobbi S , Pruccoli L , Tarozzi A , Falchi F , Andrisano V , Miszta P , Cavalli A , Filipek S , Bisi A , Rampa A |
| Ref : ChemMedChem , 11 :1296 , 2016 |
| Abstract : |
| PubMedSearch : Montanari_2016_ChemMedChem_11_1296 |
| PubMedID: 26507467 |
| Title : Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease - Prati_2016_Molecules_21_ |
| Author(s) : Prati F , Cavalli A , Bolognesi ML |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Prati_2016_Molecules_21_ |
| PubMedID: 27070562 |
| Title : Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets - Palermo_2015_PLoS.Comput.Biol_11_e1004231 |
| Author(s) : Palermo G , Bauer I , Campomanes P , Cavalli A , Armirotti A , Girotto S , Rothlisberger U , De Vivo M |
| Ref : PLoS Comput Biol , 11 :e1004231 , 2015 |
| Abstract : |
| PubMedSearch : Palermo_2015_PLoS.Comput.Biol_11_e1004231 |
| PubMedID: 26111155 |
| Title : From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold - Rampa_2015_Bioorg.Med.Chem.Lett_25_2804 |
| Author(s) : Rampa A , Mancini F , De Simone A , Falchi F , Belluti F , Di Martino RM , Gobbi S , Andrisano V , Tarozzi A , Bartolini M , Cavalli A , Bisi A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :2804 , 2015 |
| Abstract : |
| PubMedSearch : Rampa_2015_Bioorg.Med.Chem.Lett_25_2804 |
| PubMedID: 26003339 |
| Title : Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease - Belluti_2014_Eur.J.Med.Chem_78C_157 |
| Author(s) : Belluti F , De Simone A , Tarozzi A , Bartolini M , Djemil A , Bisi A , Gobbi S , Montanari S , Cavalli A , Andrisano V , Bottegoni G , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 78C :157 , 2014 |
| Abstract : |
| PubMedSearch : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| PubMedID: 24681980 |
| Title : Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease - Capurro_2013_PLoS.One_8_e56870 |
| Author(s) : Capurro V , Busquet P , Lopes JP , Bertorelli R , Tarozzo G , Bolognesi ML , Piomelli D , Reggiani A , Cavalli A |
| Ref : PLoS ONE , 8 :e56870 , 2013 |
| Abstract : |
| PubMedSearch : Capurro_2013_PLoS.One_8_e56870 |
| PubMedID: 23441223 |
| Title : Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity - Lopes_2013_Brain.Behav_3_67 |
| Author(s) : Lopes JP , Tarozzo G , Reggiani A , Piomelli D , Cavalli A |
| Ref : Brain Behav , 3 :67 , 2013 |
| Abstract : |
| PubMedSearch : Lopes_2013_Brain.Behav_3_67 |
| PubMedID: 23532860 |
| Title : Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease - Simoni_2012_J.Med.Chem_55_9708 |
| Author(s) : Simoni E , Daniele S , Bottegoni G , Pizzirani D , Trincavelli ML , Goldoni L , Tarozzo G , Reggiani A , Martini C , Piomelli D , Melchiorre C , Rosini M , Cavalli A |
| Ref : Journal of Medicinal Chemistry , 55 :9708 , 2012 |
| Abstract : |
| PubMedSearch : Simoni_2012_J.Med.Chem_55_9708 |
| PubMedID: 23033965 |
| Title : Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Belluti_2011_Eur.J.Med.Chem_46_1682 |
| Author(s) : Belluti F , Bartolini M , Bottegoni G , Bisi A , Cavalli A , Andrisano V , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 46 :1682 , 2011 |
| Abstract : |
| PubMedSearch : Belluti_2011_Eur.J.Med.Chem_46_1682 |
| PubMedID: 21397996 |
| Title : Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 - Rizzo_2010_Bioorg.Med.Chem_18_1749 |
| Author(s) : Rizzo S , Bartolini M , Ceccarini L , Piazzi L , Gobbi S , Cavalli A , Recanatini M , Andrisano V , Rampa A |
| Ref : Bioorganic & Medicinal Chemistry , 18 :1749 , 2010 |
| Abstract : |
| PubMedSearch : Rizzo_2010_Bioorg.Med.Chem_18_1749 |
| PubMedID: 20171894 |
| Title : Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks - Bolognesi_2009_J.Med.Chem_52_7883 |
| Author(s) : Bolognesi ML , Cavalli A , Bergamini C , Fato R , Lenaz G , Rosini M , Bartolini M , Andrisano V , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 52 :7883 , 2009 |
| Abstract : |
| PubMedSearch : Bolognesi_2009_J.Med.Chem_52_7883 |
| PubMedID: 19813747 |
| Title : Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors - Belluti_2009_Eur.J.Med.Chem_44_1341 |
| Author(s) : Belluti F , Piazzi L , Bisi A , Gobbi S , Bartolini M , Cavalli A , Valenti P , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 44 :1341 , 2009 |
| Abstract : |
| PubMedSearch : Belluti_2009_Eur.J.Med.Chem_44_1341 |
| PubMedID: 18396354 |
| Title : Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine - Rizzo_2009_ChemMedChem_4_670 |
| Author(s) : Rizzo S , Cavalli A , Ceccarini L , Bartolini M , Belluti F , Bisi A , Andrisano V , Recanatini M , Rampa A |
| Ref : ChemMedChem , 4 :670 , 2009 |
| Abstract : |
| PubMedSearch : Rizzo_2009_ChemMedChem_4_670 |
| PubMedID: 19222043 |
| Title : The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge - Petraglio_2008_Proteins_70_779 |
| Author(s) : Petraglio G , Bartolini M , Branduardi D , Andrisano V , Recanatini M , Gervasio FL , Cavalli A , Parrinello M |
| Ref : Proteins , 70 :779 , 2008 |
| Abstract : |
| PubMedSearch : Petraglio_2008_Proteins_70_779 |
| PubMedID: 17729290 |
| Title : Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds - Piazzi_2008_Bioorg.Med.Chem.Lett_18_423 |
| Author(s) : Piazzi L , Cavalli A , Colizzi F , Belluti F , Bartolini M , Mancini F , Recanatini M , Andrisano V , Rampa A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :423 , 2008 |
| Abstract : |
| PubMedSearch : Piazzi_2008_Bioorg.Med.Chem.Lett_18_423 |
| PubMedID: 17998161 |
| Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008 |
| Abstract : |
| PubMedSearch : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedID: 18605718 |
| Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer - Tumiatti_2008_J.Med.Chem_51_7308 |
| Author(s) : Tumiatti V , Milelli A , Minarini A , Rosini M , Bolognesi ML , Micco M , Andrisano V , Bartolini M , Mancini F , Recanatini M , Cavalli A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :7308 , 2008 |
| Abstract : |
| PubMedSearch : Tumiatti_2008_J.Med.Chem_51_7308 |
| PubMedID: 18954037 |
| Title : Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease - Bolognesi_2007_J.Med.Chem_50_6446 |
| Author(s) : Bolognesi ML , Cavalli A , Valgimigli L , Bartolini M , Rosini M , Andrisano V , Recanatini M , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 50 :6446 , 2007 |
| Abstract : |
| PubMedSearch : Bolognesi_2007_J.Med.Chem_50_6446 |
| PubMedID: 18047264 |
| Title : Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives - Piazzi_2007_J.Med.Chem_50_4250 |
| Author(s) : Piazzi L , Cavalli A , Belluti F , Bisi A , Gobbi S , Rizzo S , Bartolini M , Andrisano V , Recanatini M , Rampa A |
| Ref : Journal of Medicinal Chemistry , 50 :4250 , 2007 |
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| PubMedSearch : Piazzi_2007_J.Med.Chem_50_4250 |
| PubMedID: 17655212 |
| Title : Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation - Belluti_2005_J.Med.Chem_48_4444 |
| Author(s) : Belluti F , Rampa A , Piazzi L , Bisi A , Gobbi S , Bartolini M , Andrisano V , Cavalli A , Recanatini M , Valenti P |
| Ref : Journal of Medicinal Chemistry , 48 :4444 , 2005 |
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| PubMedSearch : Belluti_2005_J.Med.Chem_48_4444 |
| PubMedID: 15974596 |
| Title : Heterocyclic inhibitors of AChE acylation and peripheral sites - Bolognesi_2005_Farmaco_60_465 |
| Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Cavalli A , Minarini A , Recanatini M , Rosini M , Tumiatti V , Melchiorre C |
| Ref : Farmaco , 60 :465 , 2005 |
| Abstract : |
| PubMedSearch : Bolognesi_2005_Farmaco_60_465 |
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| Title : Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues - Bolognesi_2004_J.Med.Chem_47_5945 |
| Author(s) : Bolognesi ML , Bartolini M , Cavalli A , Andrisano V , Rosini M , Minarini A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 47 :5945 , 2004 |
| Abstract : |
| PubMedSearch : Bolognesi_2004_J.Med.Chem_47_5945 |
| PubMedID: 15537349 |
| Title : A computational study of the binding of propidium to the peripheral anionic site of human acetylcholinesterase - Cavalli_2004_J.Med.Chem_47_3991 |
| Author(s) : Cavalli A , Bottegoni G , Raco C , De Vivo M , Recanatini M |
| Ref : Journal of Medicinal Chemistry , 47 :3991 , 2004 |
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| PubMedSearch : Cavalli_2004_J.Med.Chem_47_3991 |
| PubMedID: 15267237 |
| Title : 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy - Piazzi_2003_J.Med.Chem_46_2279 |
| Author(s) : Piazzi L , Rampa A , Bisi A , Gobbi S , Belluti F , Cavalli A , Bartolini M , Andrisano V , Valenti P , Recanatini M |
| Ref : Journal of Medicinal Chemistry , 46 :2279 , 2003 |
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| PubMedSearch : Piazzi_2003_J.Med.Chem_46_2279 |
| PubMedID: 12773032 |
| Title : A structural model of agonist binding to the alpha3beta4 neuronal nicotinic receptor - Costa_2003_Br.J.Pharmacol_140_921 |
| Author(s) : Costa V , Nistri A , Cavalli A , Carloni P |
| Ref : British Journal of Pharmacology , 140 :921 , 2003 |
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| PubMedSearch : Costa_2003_Br.J.Pharmacol_140_921 |
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| Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine - Tumiatti_2003_J.Med.Chem_46_954 |
| Author(s) : Tumiatti V , Rosini M , Bartolini M , Cavalli A , Marucci G , Andrisano V , Angeli P , Banzi R , Minarini A , Recanatini M , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 46 :954 , 2003 |
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| PubMedSearch : Tumiatti_2003_J.Med.Chem_46_954 |
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| Title : Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol - Varoli_2003_Farmaco_58_651 |
| Author(s) : Varoli L , Angeli P , Buccioni M , Burnelli S , Cavalli A , Marucci G , Recanatini M |
| Ref : Farmaco , 58 :651 , 2003 |
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| PubMedSearch : Varoli_2003_Farmaco_58_651 |
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| Title : Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography - Bartolini_2002_J.Chromatogr.A_958_59 |
| Author(s) : Bartolini M , Bertucci C , Gotti R , Tumiatti V , Cavalli A , Recanatini M , Andrisano V |
| Ref : Journal of Chromatography A , 958 :59 , 2002 |
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| PubMedSearch : Bartolini_2002_J.Chromatogr.A_958_59 |
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| Title : Synthesis and Screening for Antiacetylcholinesterase Activity of (1-Benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles Related to Donepezil - Andreani_2001_J.Med.Chem_44_4011 |
| Author(s) : Andreani A , Cavalli A , Granaiola M , Guardigli M , Leoni A , Locatelli A , Morigi R , Rambaldi M , Recanatini M , Roda A |
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| PubMedSearch : Andreani_2001_J.Med.Chem_44_4011 |
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| Title : Acetylcholinesterase Inhibitors: SAR and Kinetic Studies on omega-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives - Rampa_2001_J.Med.Chem_44_3810 |
| Author(s) : Rampa A , Piazzi L , Belluti F , Gobbi S , Bisi A , Bartolini M , Andrisano V , Cavrini V , Cavalli A , Recanatini M , Valenti P |
| Ref : Journal of Medicinal Chemistry , 44 :3810 , 2001 |
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| Title : SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues - Recanatini_2000_J.Med.Chem_43_2007 |
| Author(s) : Recanatini M , Cavalli A , Belluti F , Piazzi L , Rampa A , Bisi A , Gobbi S , Valenti P , Andrisano V , Bartolini M , Cavrini V |
| Ref : Journal of Medicinal Chemistry , 43 :2007 , 2000 |
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| PubMedSearch : Recanatini_2000_J.Med.Chem_43_2007 |
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| Title : [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors - Tumiatti_2000_Bioorg.Med.Chem_8_681 |
| Author(s) : Tumiatti V , Angeli P , Andrisano V , Bolognesi ML , Cavalli A , Marucci G , Minarini A , Recanatini M , Rosini M , Melchiorre C |
| Ref : Bioorganic & Medicinal Chemistry , 8 :681 , 2000 |
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| PubMedSearch : Tumiatti_2000_Bioorg.Med.Chem_8_681 |
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| Title : Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives - Rampa_2000_Bioorg.Med.Chem_8_497 |
| Author(s) : Rampa A , Bisi A , Belluti F , Gobbi S , Valenti P , Andrisano V , Cavrini V , Cavalli A , Recanatini M |
| Ref : Bioorganic & Medicinal Chemistry , 8 :497 , 2000 |
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| PubMedSearch : Rampa_2000_Bioorg.Med.Chem_8_497 |
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| Title : Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease - |
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| Author(s) : Rampa A , Bisi A , Valenti P , Recanatini M , Cavalli A , Andrisano V , Cavrini V , Fin L , Buriani A , Giusti P |
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| Title : Release of acetylcholine by Xenopus oocytes injected with mRNAs from cholinergic neurons - Cavalli_1991_EMBO.J_10_1671 |
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