| Title : Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors - Wallace_2008_Bioorg.Med.Chem.Lett_18_2362 |
| Author(s) : Wallace MB , Feng J , Zhang Z , Skene RJ , Shi L , Caster CL , Kassel DB , Xu R , Gwaltney SL, 2nd |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2362 , 2008 |
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Abstract :
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery of potent and selective inhibitors with excellent pharmaceutical properties. |
| PubMedSearch : Wallace_2008_Bioorg.Med.Chem.Lett_18_2362 |
| PubMedID: 18346892 |
| Gene_locus related to this paper: human-DPP4 |
| Inhibitor | 2-phenylbenzylamine Benzimidazole-derivative-2 |
| Gene_locus | human-DPP4 |
| Structure | 3CCB 3CCC |
Wallace MB, Feng J, Zhang Z, Skene RJ, Shi L, Caster CL, Kassel DB, Xu R, Gwaltney SL, 2nd (2008)
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
18 :2362
Wallace MB, Feng J, Zhang Z, Skene RJ, Shi L, Caster CL, Kassel DB, Xu R, Gwaltney SL, 2nd (2008)
Bioorganic & Medicinal Chemistry Lett
18 :2362