| Title : miR-4454 up-regulated by HPV16 E6\/E7 promotes invasion and migration by targeting ABHD2\/NUDT21 in cervical cancer - Wang_2020_Biosci.Rep_40_ |
| Author(s) : Wang H , Hu H , Luo Z , Liu S , Wu W , Zhu M , Wang J , Liu Y , Lu Z |
| Ref : Bioscience Reports , 40 : , 2020 |
|
Abstract :
The abnormal expression of HPV16 E6/E7 activates oncogenes and/or inactivates tumor suppressor genes, resulting in the selective growth and malignant transformation of cancer cells. miR-4454 was selected by sequencing due to its abnormal high expression in HPV16 E6/E7 positive CaSki cell compared with HPV16 E6/E7 negative C33A cell. Overexpression of miR-4454 enhances cervical cancer cell invasion and migration. ABHD2 and NUDT21 are identified as a target gene of miR-4454.The effects of ABHD2 and NUDT21 on migration and invasion of CaSki and C33A cells were determined. The dual luciferase and RT-qPCR assays confirmed that miR-4454 might regulate its targets ABHD2 and NUDT21 to promote the proliferation, invasion and migration, whereas, inhibit the apoptosis in CaSki and C33A cells. |
| PubMedSearch : Wang_2020_Biosci.Rep_40_ |
| PubMedID: 32816024 |
Wang H, Hu H, Luo Z, Liu S, Wu W, Zhu M, Wang J, Liu Y, Lu Z (2020)
miR-4454 up-regulated by HPV16 E6\/E7 promotes invasion and migration by targeting ABHD2\/NUDT21 in cervical cancer
Bioscience Reports
40 :
Wang H, Hu H, Luo Z, Liu S, Wu W, Zhu M, Wang J, Liu Y, Lu Z (2020)
Bioscience Reports
40 :