Watanabe_2013_Toxicol.Appl.Pharmacol_272_61

Reference

Title : Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats - Watanabe_2013_Toxicol.Appl.Pharmacol_272_61
Author(s) : Watanabe Y , Itoh T , Shiraishi H , Maeno Y , Arima Y , Torikoshi A , Namera A , Makita R , Yoshizumi M , Nagao M
Ref : Toxicol Appl Pharmacol , 272 :61 , 2013
Abstract : The organophosphorus compound sarin irreversibly inhibits acetylcholinesterase. We examined the acute cardiovascular effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate (BIMP), in anaesthetized, artificially ventilated rats. Intravenous administration of BIMP (0.8mg/kg; the LD50 value) induced a long-lasting increase in blood pressure and tended to increase heart rate. In rats pretreated with the non-selective muscarinic-receptor antagonist atropine, BIMP significantly increased both heart rate and blood pressure. In atropine-treated rats, hexamethonium (antagonist of ganglionic nicotinic receptors) greatly attenuated the BIMP-induced increase in blood pressure without changing the BIMP-induced increase in heart rate. In rats treated with atropine plus hexamethonium, intravenous phentolamine (non-selective alpha-adrenergic receptor antagonist) plus propranolol (non-selective beta-adrenergic receptor antagonist) completely blocked the BIMP-induced increases in blood pressure and heart rate. In atropine-treated rats, the reversible acetylcholinesterase inhibitor neostigmine (1mg/kg) induced a transient increase in blood pressure, but had no effect on heart rate. These results suggest that in anaesthetized rats, BIMP induces powerful stimulation of sympathetic as well as parasympathetic nerves and thereby modulates heart rate and blood pressure. They may also indicate that an action independent of acetylcholinesterase inhibition contributes to the acute cardiovascular responses induced by BIMP.
ESTHER : Watanabe_2013_Toxicol.Appl.Pharmacol_272_61
PubMedSearch : Watanabe_2013_Toxicol.Appl.Pharmacol_272_61
PubMedID: 23769715

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Citations formats

Watanabe Y, Itoh T, Shiraishi H, Maeno Y, Arima Y, Torikoshi A, Namera A, Makita R, Yoshizumi M, Nagao M (2013)
Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats
Toxicol Appl Pharmacol 272 :61

Watanabe Y, Itoh T, Shiraishi H, Maeno Y, Arima Y, Torikoshi A, Namera A, Makita R, Yoshizumi M, Nagao M (2013)
Toxicol Appl Pharmacol 272 :61