| Title : Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues - Wei_2003_Org.Biomol.Chem_1_3878 |
| Author(s) : Wei ZL , Xiao Y , George C , Kellar KJ , Kozikowski AP |
| Ref : Org Biomol Chem , 1 :3878 , 2003 |
|
Abstract :
A novel method for the epimerization of endo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptan-3-one (12) on silica gel was developed and used as the key step to synthesize functionalized analogues of epibatidine which were evaluated for their nicotine receptor subtype selectivity in binding studies. |
| PubMedSearch : Wei_2003_Org.Biomol.Chem_1_3878 |
| PubMedID: 14664377 |
Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP (2003)
Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues
Org Biomol Chem
1 :3878
Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP (2003)
Org Biomol Chem
1 :3878