Wilson_2014_Nature_506_58

Reference

Title : An environmental bacterial taxon with a large and distinct metabolic repertoire - Wilson_2014_Nature_506_58
Author(s) : Wilson MC , Mori T , Ruckert C , Uria AR , Helf MJ , Takada K , Gernert C , Steffens UA , Heycke N , Schmitt S , Rinke C , Helfrich EJ , Brachmann AO , Gurgui C , Wakimoto T , Kracht M , Crusemann M , Hentschel U , Abe I , Matsunaga S , Kalinowski J , Takeyama H , Piel J
Ref : Nature , 506 :58 , 2014
Abstract :

Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Here we report the single-cell- and metagenomics-based discovery of such producers. Two phylotypes of the candidate genus 'Entotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei. Almost all bioactive polyketides and peptides known from this animal were attributed to a single phylotype. 'Entotheonella' spp. are widely distributed in sponges and belong to an environmental taxon proposed here as candidate phylum 'Tectomicrobia'. The pronounced bioactivities and chemical uniqueness of 'Entotheonella' compounds provide significant opportunities for ecological studies and drug discovery.

PubMedSearch : Wilson_2014_Nature_506_58
PubMedID: 24476823
Gene_locus related to this paper: 9delt-w4lci7 , 9delt-w4lkq9 , 9delt-w4lj58 , 9delt-w4l7a4 , 9delt-w4m617

Related information

Gene_locus 9delt-w4lci7    9delt-w4lkq9    9delt-w4lj58    9delt-w4l7a4    9delt-w4m617
Gene_locus_frgt 9delt-w4lci7    9delt-w4lkq9    9delt-w4lj58    9delt-w4l7a4    9delt-w4m617    9delt-w4lbk5    9bact-w4m440

Citations formats

Wilson MC, Mori T, Ruckert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, Wakimoto T, Kracht M, Crusemann M, Hentschel U, Abe I, Matsunaga S, Kalinowski J, Takeyama H, Piel J (2014)
An environmental bacterial taxon with a large and distinct metabolic repertoire
Nature 506 :58

Wilson MC, Mori T, Ruckert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, Wakimoto T, Kracht M, Crusemann M, Hentschel U, Abe I, Matsunaga S, Kalinowski J, Takeyama H, Piel J (2014)
Nature 506 :58