Title : Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells - Woo_2012_Int.J.Mol.Med_29_403 |
Author(s) : Woo Y , Shin SY , Hyun J , Lee SD , Lee YH , Lim Y |
Ref : Int J Mol Med , 29 :403 , 2012 |
Abstract :
Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined. |
PubMedSearch : Woo_2012_Int.J.Mol.Med_29_403 |
PubMedID: 22160193 |
Woo Y, Shin SY, Hyun J, Lee SD, Lee YH, Lim Y (2012)
Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells
Int J Mol Med
29 :403
Woo Y, Shin SY, Hyun J, Lee SD, Lee YH, Lim Y (2012)
Int J Mol Med
29 :403