| Title : Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities - Xiao_2022_J.Fungi.(Basel)_8_ |
| Author(s) : Xiao Y , Liang W , Zhang Z , Wang Y , Zhang S , Liu J , Chang J , Ji C , Zhu D |
| Ref : J Fungi (Basel) , 8 : , 2022 |
| Abstract : The secondary metabolites of Phaeosphaeria sp. LF5, an endophytic fungus with acetylcholinesterase (AChE) inhibitory activity isolated from Huperzia serrata, were investigated. Their structures and absolute configurations were elucidated by means of extensive spectroscopic data, including one- and two-dimensional nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses, and calculations of electronic circular dichroism (ECD). A chemical study on the solid-cultured fungus LF5 resulted in 11 polyketide derivatives, which included three previously undescribed derivatives: aspilactonol I (4), 2-(1-hydroxyethyl)-6-methylisonicotinic acid (7), and 6,8-dihydroxy-3-(1'R, 2'R-dihydroxypropyl)-isocoumarin (9), and two new natural-source-derived aspilactonols (G, H) (2, 3). Moreover, the absolute configuration of de-O-methyldiaporthin (11) was identified for the first time. Compounds 4 and 11 exhibited inhibitory activity against AChE with half maximal inhibitory concentration (IC(50)) values of 6.26 and 21.18 microM, respectively. Aspilactonol I (4) is the first reported furanone AChE inhibitor (AChEI). The results indicated that Phaeosphaeria is a good source of polyketide derivatives. This study identified intriguing lead compounds for further research and development of new AChEIs. |
| ESTHER : Xiao_2022_J.Fungi.(Basel)_8_ |
| PubMedSearch : Xiao_2022_J.Fungi.(Basel)_8_ |
| PubMedID: 35330234 |
Xiao Y, Liang W, Zhang Z, Wang Y, Zhang S, Liu J, Chang J, Ji C, Zhu D (2022)
Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities
J Fungi (Basel)
8 :
Xiao Y, Liang W, Zhang Z, Wang Y, Zhang S, Liu J, Chang J, Ji C, Zhu D (2022)
J Fungi (Basel)
8 :