| Title : Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| Author(s) : Xu J , Wei L , Mathvink R , Edmondson SD , Mastracchio A , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Petrov A , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1346 , 2006 |
|
Abstract :
anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species. |
| PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| PubMedID: 16332437 |
Xu J, Wei L, Mathvink R, Edmondson SD, Mastracchio A, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE (2006)
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors
Bioorganic & Medicinal Chemistry Lett
16 :1346
Xu J, Wei L, Mathvink R, Edmondson SD, Mastracchio A, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE (2006)
Bioorganic & Medicinal Chemistry Lett
16 :1346