Yang_2011_Toxicol.Lett_206_306

Reference

Title : Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry - Yang_2011_Toxicol.Lett_206_306
Author(s) : Yang J , Sun X , Feng Z , Hao D , Wang M , Zhao X , Sun C
Ref : Toxicol Lett , 206 :306 , 2011
Abstract :

The purpose of the current study was to assess the effects of long-term exposure to low levels of DDVP on the biochemical parameters and metabolic profiles of rats. Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. Significant changes in blood cholinesterase, creatinine, urea nitrogen, aspartate aminotransferase, alanine aminotransferase, and albumin concentrations were observed in the middle and high dose groups. Changes in the concentration of some urine metabolites were detected via ultra performance liquid chromatography-mass spectrometry (UPLC-MS). Dimethyl phosphate (DMP), which was exclusively detected in the treated groups, can be an early, sensitive biomarker for DDVP exposure. Moreover, DDVP treatment resulted in an increase in the lactobionic acid, estrone sulfate, and indoxyl sulfic concentrations, and a decrease in citric acid, suberic acid, gulonic acid, urea, creatinine, and uric acid. These results suggest that chronic exposure to low-level DDVP can cause a disturbance in carbohydrate and fatty acid metabolism, the antioxidant system, etc. Therefore, an analysis of the metabolic profiles can contribute to the understanding of the adverse effects of long-term exposure to low doses of DDVP.

PubMedSearch : Yang_2011_Toxicol.Lett_206_306
PubMedID: 21889581

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Citations formats

Yang J, Sun X, Feng Z, Hao D, Wang M, Zhao X, Sun C (2011)
Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry
Toxicol Lett 206 :306

Yang J, Sun X, Feng Z, Hao D, Wang M, Zhao X, Sun C (2011)
Toxicol Lett 206 :306