Title : Association between Lp-PLA2 and coronary heart disease in Chinese patients - Yang_2017_J.Int.Med.Res_45_159 |
Author(s) : Yang L , Liu Y , Wang S , Liu T , Cong H |
Ref : J Internal Medicine Res , 45 :159 , 2017 |
Abstract :
Objective To evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2; known to release inflammatory mediators that promote atherosclerosis) and coronary heart disease (CHD) in Chinese patients. Methods This observational, cross-sectional study included a patient cohort who were assessed by coronary angiography and divided into patients with coronary heart disease and patients with normal coronary angiography (controls). Data for several biochemical indicators were collected. Plasma Lp-PLA2 concentrations were measured by enzyme-linked immunosorbent assay. Univariate and multivariate logistic regression were used to analyse the association between Lp-PLA2 concentration and CHD. Results A total of 531 patients were included, comprising 391 with CHD and 140 with normal coronary angiography (controls). Plasma Lp-PLA2 concentration was significantly higher in patients with CHD versus controls (median, 251 microg/l versus 219 microg/l, respectively), and particularly among patients with acute myocardial infarction and stable angina pectoris (249 microg/l and 266 microg/l, respectively). Multivariate analysis showed that Lp-PLA2 <= 292 microg/l (upper quartile of the whole cohort) was independently associated with CHD (odds ratio 2.814, 95% confidence interval 1.519, 5.214). Conclusion Plasma Lp-PLA2 concentration was independently associated with CHD in Chinese patients. |
PubMedSearch : Yang_2017_J.Int.Med.Res_45_159 |
PubMedID: 28222638 |
Gene_locus related to this paper: human-PLA2G7 |
Yang L, Liu Y, Wang S, Liu T, Cong H (2017)
Association between Lp-PLA2 and coronary heart disease in Chinese patients
J Internal Medicine Res
45 :159
Yang L, Liu Y, Wang S, Liu T, Cong H (2017)
J Internal Medicine Res
45 :159