Title : Functional characterisation of Schistosoma japonicum acetylcholinesterase - You_2016_Parasit.Vectors_9_328 |
Author(s) : You H , Gobert GN , Du X , Pali G , Cai P , Jones MK , McManus DP |
Ref : Parasit Vectors , 9 :328 , 2016 |
Abstract :
BACKGROUND: Acetylcholinesterase (AChE) is an important metabolic enzyme of schistosomes present in the musculature and on the surface of the blood stage where it has been implicated in the modulation of glucose scavenging from mammalian host blood. As both a target for the antischistosomal drug metrifonate and as a potential vaccine candidate, AChE has been characterised in the schistosome species Schistosoma mansoni, S. haematobium and S. bovis, but not in S. japonicum. Recently, using a schistosome protein microarray, a predicted S. japonicum acetylcholinesterase precursor was significantly targeted by protective IgG1 immune responses in S. haematobium-exposed individuals that had acquired drug-induced resistance to schistosomiasis after praziquantel treatment. |
PubMedSearch : You_2016_Parasit.Vectors_9_328 |
PubMedID: 27283196 |
Gene_locus related to this paper: schja-a0a191sw41 |
Gene_locus | schja-a0a191sw41 |
You H, Gobert GN, Du X, Pali G, Cai P, Jones MK, McManus DP (2016)
Functional characterisation of Schistosoma japonicum acetylcholinesterase
Parasit Vectors
9 :328
You H, Gobert GN, Du X, Pali G, Cai P, Jones MK, McManus DP (2016)
Parasit Vectors
9 :328