Zhang_2021_Front.Pharmacol_12_784202

Reference

Title : Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System - Zhang_2021_Front.Pharmacol_12_784202
Author(s) : Zhang H , Li X , Liao D , Luo P , Jiang X
Ref : Front Pharmacol , 12 :784202 , 2021
Abstract :

Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). alpha/beta-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6.

PubMedSearch : Zhang_2021_Front.Pharmacol_12_784202
PubMedID: 34925039
Gene_locus related to this paper: human-ABHD6

Related information

Gene_locus human-ABHD6
Family human-ABHD6    ABHD6-Lip

Citations formats

Zhang H, Li X, Liao D, Luo P, Jiang X (2021)
Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
Front Pharmacol 12 :784202

Zhang H, Li X, Liao D, Luo P, Jiang X (2021)
Front Pharmacol 12 :784202