human-ABHD6

Homo sapiens (Human) ABHD6 Monoacylglycerol lipase EC: 3.1.1.23

Comment

Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification<\/A> of Arpigny and Jaeger 1999<\/A>. Alpha\/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.<\/A> A study by Wei et al.<\/A> shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity || Q9BV23 and Q9HBL9 differ only at cterminus (alternative splicing?)Q6ZMF7 hypothetical protein flj23958

Relationship

Family : ABHD6-Lip

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Sequence

Peptide

MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD

References (53)

Title : ABHD6 suppresses colorectal cancer progression via AKT signaling pathway - Xiong_2024_Mol.Carcinog__
Author(s) : Xiong X , Yang C , Jin Y , Zhang R , Wang S , Gan L , Hou S , Bao Y , Zeng Z , Ye Y , Gao Z
Ref : Mol Carcinog , : , 2024
PubMedID: 38197491
Gene_locus related to this paper: human-ABHD6

Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559
Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C
Ref : Prog Neurobiol , :102559 , 2023
PubMedID: 38159878
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822
Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M
Ref : Mol Metab , :101822 , 2023
PubMedID: 37838014
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe\/PS1dE9 mice - Xue_2023_Pharmacol.Res__106864
Author(s) : Xue Z , Ye L , Ge J , Lan Z , Zou X , Mao C , Bao X , Yu L , Xu Y , Zhu X
Ref : Pharmacol Res , :106864 , 2023
PubMedID: 37480972
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache - Liktor-Busa_2023_Front.Pain.Res.(Lausanne)_4_1171188
Author(s) : Liktor-Busa E , Levine AA , Palomino SM , Singh S , Wahl J , Vanderah TW , Stella N , Largent-Milnes TM
Ref : Front Pain Res (Lausanne) , 4 :1171188 , 2023
PubMedID: 37287623
Gene_locus related to this paper: human-ABHD6 , human-MGLL

Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099
Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N
Ref : Neurobiol Dis , 180 :106099 , 2023
PubMedID: 36990366
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase - Pusch_2022_Metabolites_12_761
Author(s) : Pusch LM , Riegler-Berket L , Oberer M , Zimmermann R , Taschler U
Ref : Metabolites , 12 : , 2022
PubMedID: 36005632
Gene_locus related to this paper: human-ABHD6

Title : ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB(1) Receptors - Deng_2021_Cannabis.Cannabinoid.Res__
Author(s) : Deng L , Viray K , Singh S , Cravatt B , Stella N
Ref : Cannabis Cannabinoid Res , : , 2021
PubMedID: 34705543
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status - Miralpeix_2021_Br.J.Pharmacol_178_1507
Author(s) : Miralpeix C , Reguera AC , Fosch A , Casas M , Lillo J , Navarro G , Franco R , Casas J , Alexander SPH , Casals N , Rodriguez-Rodriguez R
Ref : British Journal of Pharmacology , 178 :1507 , 2021
PubMedID: 33444462
Gene_locus related to this paper: human-ABHD6

Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6\/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity - Kokona_2021_Neuropharmacol_185_108450
Author(s) : Kokona D , Spyridakos D , Tzatzarakis M , Papadogkonaki S , Filidou E , Arvanitidis KI , Kolios G , Lamani M , Makriyannis A , Malamas MS , Thermos K
Ref : Neuropharmacology , 185 :108450 , 2021
PubMedID: 33450278
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors - Malamas_2021_ChemMedChem__
Author(s) : Malamas MS , Lamani M , Farah SI , Mohammad KA , Miyabe CY , Rajarshi G , Wu S , Zvonok N , Chandrashekhar H , Wood J , Makriyannis A
Ref : ChemMedChem , : , 2021
PubMedID: 34486233
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System - Zhang_2021_Front.Pharmacol_12_784202
Author(s) : Zhang H , Li X , Liao D , Luo P , Jiang X
Ref : Front Pharmacol , 12 :784202 , 2021
PubMedID: 34925039
Gene_locus related to this paper: human-ABHD6

Title : 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1 - Farah_2021_Biochem.Biophys.Res.Commun_591_31
Author(s) : Farah SI , Hilston S , Tran N , Zvonok N , Makriyannis A
Ref : Biochemical & Biophysical Research Communications , 591 :31 , 2021
PubMedID: 34995983
Gene_locus related to this paper: human-ABHD6 , human-MGLL

Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000
Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F
Ref : Journal of Neurochemistry , :e15000 , 2020
PubMedID: 32141088
Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL

Title : Adipose ABHD6 regulates tolerance to cold and thermogenic programs - Poursharifi_2020_JCI.Insight_5_
Author(s) : Poursharifi P , Attane C , Mugabo Y , Al-Mass A , Ghosh A , Schmitt C , Zhao S , Guida J , Lussier R , Erb H , Chenier I , Peyot ML , Joly E , Noll C , Carpentier AC , Madiraju SRM , Prentki M
Ref : JCI Insight , 5 : , 2020
PubMedID: 33201859
Gene_locus related to this paper: human-ABHD6

Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353
Author(s) : Deng H , Li W
Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020
PubMedID: 32371333
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta - Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807
Author(s) : Maia J , Fonseca BM , Cunha SC , Braga J , Goncalves D , Teixeira N , Correia-da-Silva G
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , :158807 , 2020
PubMedID: 32829065
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans - Grabner_2019_J.Lipid.Res_60_1020
Author(s) : Grabner GF , Fawzy N , Pribasnig MA , Trieb M , Taschler U , Holzer M , Schweiger M , Wolinski H , Kolb D , Horvath A , Breinbauer R , Rulicke T , Rabl R , Lass A , Stadlbauer V , Hutter-Paier B , Stauber RE , Fickert P , Zechner R , Marsche G , Eichmann TO , Zimmermann R
Ref : J Lipid Res , 60 :1020 , 2019
PubMedID: 30894461
Gene_locus related to this paper: human-ABHD6

Title : The alpha\/beta-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids - Bottemanne_2019_FASEB.J__fj201802259R
Author(s) : Bottemanne P , Paquot A , Ameraoui H , Alhouayek M , Muccioli GG
Ref : FASEB Journal , :fj201802259R , 2019
PubMedID: 30896979
Gene_locus related to this paper: human-ABHD6

Title : Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype - Rahaman_2019_J.Immunol_202_1674
Author(s) : Rahaman O , Bhattacharya R , Liu CSC , Raychaudhuri D , Ghosh AR , Bandopadhyay P , Pal S , Goswami RP , Sircar G , Ghosh P , Ganguly D
Ref : J Immunol , 202 :1674 , 2019
PubMedID: 30728209
Gene_locus related to this paper: human-ABHD6

Title : Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells - van Esbroeck_2019_Front.Mol.Neurosci_12_286
Author(s) : van Esbroeck ACM , Kantae V , Di X , van der Wel T , den Dulk H , Stevens AF , Singh S , Bakker AT , Florea BI , Stella N , Overkleeft HS , Hankemeier T , van der Stelt M
Ref : Front Mol Neurosci , 12 :286 , 2019
PubMedID: 31849602
Gene_locus related to this paper: human-ABHD6

Title : Biochemical and Proteomic Characterization of Recombinant Human alpha\/beta Hydrolase Domain 6 - Shields_2019_Sci.Rep_9_890
Author(s) : Shields CM , Zvonok N , Zvonok A , Makriyannis A
Ref : Sci Rep , 9 :890 , 2019
PubMedID: 30696836
Gene_locus related to this paper: human-ABHD6

Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267
Author(s) : Cao JK , Kaplan J , Stella N
Ref : Trends in Pharmacological Sciences , 40 :267 , 2019
PubMedID: 30853109
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells - Drehmer_2019_Biochem.Genet_57_35
Author(s) : Drehmer MN , Muniz YCN , Marrero AR , Lofgren SE
Ref : Biochemical Genetics , 57 :35 , 2019
PubMedID: 30006903
Gene_locus related to this paper: human-ABHD6

Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337
Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N
Ref : J Leukoc Biol , 106 :1337 , 2019
PubMedID: 31556464
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1

Title : Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease - Kind_2019_Amino.Acids_51_151
Author(s) : Kind L , Kursula P
Ref : Amino Acids , 51 :151 , 2018
PubMedID: 30564946
Gene_locus related to this paper: human-ABHD6 , human-ABHD12

Title : Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis - Manterola_2018_Neuropharmacol_141_181
Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Ruiz A , Perez-Samartin A , Moreno-Rodriguez M , Hsu KL , Cravatt BF , Brown JM , Rodriguez-Puertas R , Matute C , Mato S
Ref : Neuropharmacology , 141 :181 , 2018
PubMedID: 30171986
Gene_locus related to this paper: human-ABHD6

Title : Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination - Manterola_2018_Biochem.Pharmacol_157_189
Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Canedo-Antelo M , Moreno-Garcia A , Martin-Fontecha M , Perez-Cerda F , Sanchez-Gomez MV , Ortega-Gutierrez S , Brown JM , Hsu KL , Cravatt B , Matute C , Mato S
Ref : Biochemical Pharmacology , 157 :189 , 2018
PubMedID: 30075103
Gene_locus related to this paper: human-ABHD6

Title : Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases - Baggelaar_2017_ACS.Chem.Biol_12_852
Author(s) : Baggelaar MP , van Esbroeck AC , van Rooden EJ , Florea BI , Overkleeft HS , Marsicano G , Chaouloff F , van der Stelt M
Ref : ACS Chemical Biology , 12 :852 , 2017
PubMedID: 28106377
Gene_locus related to this paper: human-ABHD4 , human-ABHD6 , human-ABHD12 , human-DAGLA , human-MGLL

Title : Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors - Deng_2017_Medchemcomm_8_982
Author(s) : Deng H , van der Wel T , van den Berg R , van den Nieuwendijk A , Janssen FJ , Baggelaar MP , Overkleeft HS , van der Stelt M
Ref : Medchemcomm , 8 :982 , 2017
PubMedID: 30108813
Gene_locus related to this paper: human-ABHD6

Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872
Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M
Ref : Cell Rep , 14 :2872 , 2016
PubMedID: 26997277
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors - Wei_2016_Proc.Natl.Acad.Sci.U.S.A_113_E2695
Author(s) : Wei M , Zhang J , Jia M , Yang C , Pan Y , Li S , Luo Y , Zheng J , Ji J , Chen J , Hu X , Xiong J , Shi Y , Zhang C
Ref : Proc Natl Acad Sci U S A , 113 :E2695 , 2016
PubMedID: 27114538
Gene_locus related to this paper: human-ABHD6

Title : alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility - Fisette_2016_Cell.Rep_17_1217
Author(s) : Fisette A , Tobin S , Decarie-Spain L , Bouyakdan K , Peyot ML , Madiraju SR , Prentki M , Fulton S , Alquier T
Ref : Cell Rep , 17 :1217 , 2016
PubMedID: 27783937
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal\/Lysosomal Lipid Bis(monoacylglycero)phosphate - Pribasnig_2015_J.Biol.Chem_290_29869
Author(s) : Pribasnig MA , Mrak I , Grabner GF , Taschler U , Knittelfelder O , Scherz B , Eichmann TO , Heier C , Grumet L , Kowaliuk J , Romauch M , Holler S , Anderl F , Wolinski H , Lass A , Breinbauer R , Marsche G , Brown JM , Zimmermann R
Ref : Journal of Biological Chemistry , 290 :29869 , 2015
PubMedID: 26491015
Gene_locus related to this paper: human-ABHD6

Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253
Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T
Ref : ChemMedChem , 10 :253 , 2015
PubMedID: 25504894
Gene_locus related to this paper: human-ABHD6

Title : alpha\/beta-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli - Zhao_2015_Mol.Metab_4_940
Author(s) : Zhao S , Poursharifi P , Mugabo Y , Levens EJ , Vivot K , Attane C , Iglesias J , Peyot ML , Joly E , Madiraju SR , Prentki M
Ref : Mol Metab , 4 :940 , 2015
PubMedID: 26909310
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family - Thomas_2014_Biochim.Biophys.Acta_1841_1097
Author(s) : Thomas G , Brown AL , Brown JM
Ref : Biochimica & Biophysica Acta , 1841 :1097 , 2014
PubMedID: 24423940
Gene_locus related to this paper: human-ABHD3 , human-ABHD6 , human-ABHD12

Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361
Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N
Ref : Neuron , 83 :361 , 2014
PubMedID: 25033180
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522
Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT
Ref : Molecular Pharmacology , 86 :522 , 2014
PubMedID: 25140003
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome - Thomas_2013_Cell.Rep_5_508
Author(s) : Thomas G , Betters JL , Lord CC , Brown AL , Marshall S , Ferguson D , Sawyer J , Davis MA , Melchior JT , Blume LC , Howlett AC , Ivanova PT , Milne SB , Myers DS , Mrak I , Leber V , Heier C , Taschler U , Blankman JL , Cravatt BF , Lee RG , Crooke RM , Graham MJ , Zimmermann R , Brown HA , Brown JM
Ref : Cell Rep , 5 :508 , 2013
PubMedID: 24095738
Gene_locus related to this paper: human-ABHD6

Title : Highly predictive ligand-based pharmacophore and homology models of ABHD6 - Bowman_2013_Chem.Biol.Drug.Des_81_382
Author(s) : Bowman AL , Makriyannis A
Ref : Chemical Biology Drug Des , 81 :382 , 2013
PubMedID: 23110439
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6 - Alhouayek_2013_Proc.Natl.Acad.Sci.U.S.A_110_17558
Author(s) : Alhouayek M , Masquelier J , Cani PD , Lambert DM , Muccioli GG
Ref : Proc Natl Acad Sci U S A , 110 :17558 , 2013
PubMedID: 24101490
Gene_locus related to this paper: human-ABHD6

Title : Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) - Hsu_2012_Probe.Report__
Author(s) : Hsu KL , Tsuboi K , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H
Ref : Probe Report , : , 2012
PubMedID: 23658950
Gene_locus related to this paper: human-ABHD6

Title : Biochemical and pharmacological characterization of human alpha\/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) - Navia-Paldanius_2012_J.Lipid.Res_53_2413
Author(s) : Navia-Paldanius D , Savinainen JR , Laitinen JT
Ref : J Lipid Res , 53 :2413 , 2012
PubMedID: 22969151
Gene_locus related to this paper: human-ABHD6 , human-ABHD12

Title : The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors - Savinainen_2012_Acta.Physiol.(Oxf)_204_267
Author(s) : Savinainen JR , Saario SM , Laitinen JT
Ref : Acta Physiol (Oxf) , 204 :267 , 2012
PubMedID: 21418147
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone - Matuszak_2011_Bioorg.Med.Chem.Lett_21_7321
Author(s) : Matuszak N , Es Saadi B , Labar G , Marchand-Brynaert J , Lambert DM
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :7321 , 2011
PubMedID: 22056744
Gene_locus related to this paper: human-ABHD6

Title : Dual inhibition of alpha\/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons - Marrs_2011_J.Biol.Chem_286_28723
Author(s) : Marrs WR , Horne EA , Ortega-Gutierrez S , Cisneros JA , Xu C , Lin YH , Muccioli GG , Lopez-Rodriguez ML , Stella N
Ref : Journal of Biological Chemistry , 286 :28723 , 2011
PubMedID: 21665953
Gene_locus related to this paper: human-ABHD6

Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951
Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N
Ref : Nat Neurosci , 13 :951 , 2010
PubMedID: 20657592
Gene_locus related to this paper: human-ABHD6

Title : A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors - King_2009_Br.J.Pharmacol_157_974
Author(s) : King AR , Lodola A , Carmi C , Fu J , Mor M , Piomelli D
Ref : British Journal of Pharmacology , 157 :974 , 2009
PubMedID: 19486005
Gene_locus related to this paper: human-ABHD6

Title : High expression of the evolutionarily conserved alpha\/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors - Max_2009_Cancer.Sci_100_2383
Author(s) : Max D , Hesse M , Volkmer I , Staege MS
Ref : Cancer Sci , 100 :2383 , 2009
PubMedID: 19793082
Gene_locus related to this paper: human-ABHD6

Title : An unannotated alpha\/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines - Li_2009_Mol.Biol.Rep_36_691
Author(s) : Li F , Fei X , Xu J , Ji C
Ref : Mol Biol Rep , 36 :691 , 2009
PubMedID: 18360779
Gene_locus related to this paper: human-ABHD6

Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347
Author(s) : Blankman JL , Simon GM , Cravatt BF
Ref : Chemical Biology , 14 :1347 , 2007
PubMedID: 18096503
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A