human-ABHD6
Homo sapiens (Human) ABHD6 Monoacylglycerol lipase EC: 3.1.1.23
Comment
Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification<\/A> of Arpigny and Jaeger 1999<\/A>. Alpha\/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.<\/A> A study by Wei et al.<\/A> shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity || Q9BV23 and Q9HBL9 differ only at cterminus (alternative splicing?)Q6ZMF7 hypothetical protein flj23958
Relationship
Family : ABHD6-Lip
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD
References (56)
| Title : ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice - Lau_2024_Nat.Commun_15_10652 |
| Author(s) : Lau D , Tobin S , Pribiag H , Nakajima S , Fisette A , Matthys D , Franco Flores AK , Peyot ML , Murthy Madiraju SR , Prentki M , Stellwagen D , Alquier T , Fulton S |
| Ref : Nat Commun , 15 :10652 , 2024 |
| Abstract : |
| PubMedSearch : Lau_2024_Nat.Commun_15_10652 |
| PubMedID: 39681558 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 suppresses colorectal cancer progression via AKT signaling pathway - Xiong_2024_Mol.Carcinog__ |
| Author(s) : Xiong X , Yang C , Jin Y , Zhang R , Wang S , Gan L , Hou S , Bao Y , Zeng Z , Ye Y , Gao Z |
| Ref : Mol Carcinog , : , 2024 |
| Abstract : |
| PubMedSearch : Xiong_2024_Mol.Carcinog__ |
| PubMedID: 38197491 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Elucidating genetic and molecular basis of altered higher-order brain structure-function coupling in major depressive disorder - Long_2024_Neuroimage_297_120722 |
| Author(s) : Long H , Chen Z , Xu X , Zhou Q , Fang Z , Lv M , Yang XH , Xiao J , Sun H , Fan M |
| Ref : Neuroimage , 297 :120722 , 2024 |
| Abstract : |
| PubMedSearch : Long_2024_Neuroimage_297_120722 |
| PubMedID: 38971483 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes - Ciuffreda_2024_Int.J.Mol.Sci_25_7693 |
| Author(s) : Ciuffreda P , Xynomilakis O , Casati S , Ottria R |
| Ref : Int J Mol Sci , 25 :7693 , 2024 |
| Abstract : |
| PubMedSearch : Ciuffreda_2024_Int.J.Mol.Sci_25_7693 |
| PubMedID: 39062935 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559 |
| Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C |
| Ref : Prog Neurobiol , :102559 , 2023 |
| Abstract : |
| PubMedSearch : Wei_2023_Prog.Neurobiol__102559 |
| PubMedID: 38159878 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822 |
| Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M |
| Ref : Mol Metab , :101822 , 2023 |
| Abstract : |
| PubMedSearch : Poursharifi_2023_Mol.Metab__101822 |
| PubMedID: 37838014 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe\/PS1dE9 mice - Xue_2023_Pharmacol.Res__106864 |
| Author(s) : Xue Z , Ye L , Ge J , Lan Z , Zou X , Mao C , Bao X , Yu L , Xu Y , Zhu X |
| Ref : Pharmacol Res , :106864 , 2023 |
| Abstract : |
| PubMedSearch : Xue_2023_Pharmacol.Res__106864 |
| PubMedID: 37480972 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache - Liktor-Busa_2023_Front.Pain.Res.(Lausanne)_4_1171188 |
| Author(s) : Liktor-Busa E , Levine AA , Palomino SM , Singh S , Wahl J , Vanderah TW , Stella N , Largent-Milnes TM |
| Ref : Front Pain Res (Lausanne) , 4 :1171188 , 2023 |
| Abstract : |
| PubMedSearch : Liktor-Busa_2023_Front.Pain.Res.(Lausanne)_4_1171188 |
| PubMedID: 37287623 |
| Gene_locus related to this paper: human-ABHD6 , human-MGLL |
| Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099 |
| Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N |
| Ref : Neurobiol Dis , 180 :106099 , 2023 |
| Abstract : |
| PubMedSearch : Westenbroek_2023_Neurobiol.Dis_180_106099 |
| PubMedID: 36990366 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase - Pusch_2022_Metabolites_12_761 |
| Author(s) : Pusch LM , Riegler-Berket L , Oberer M , Zimmermann R , Taschler U |
| Ref : Metabolites , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Pusch_2022_Metabolites_12_761 |
| PubMedID: 36005632 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB(1) Receptors - Deng_2021_Cannabis.Cannabinoid.Res__ |
| Author(s) : Deng L , Viray K , Singh S , Cravatt B , Stella N |
| Ref : Cannabis Cannabinoid Res , : , 2021 |
| Abstract : |
| PubMedSearch : Deng_2021_Cannabis.Cannabinoid.Res__ |
| PubMedID: 34705543 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status - Miralpeix_2021_Br.J.Pharmacol_178_1507 |
| Author(s) : Miralpeix C , Reguera AC , Fosch A , Casas M , Lillo J , Navarro G , Franco R , Casas J , Alexander SPH , Casals N , Rodriguez-Rodriguez R |
| Ref : British Journal of Pharmacology , 178 :1507 , 2021 |
| Abstract : |
| PubMedSearch : Miralpeix_2021_Br.J.Pharmacol_178_1507 |
| PubMedID: 33444462 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6\/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity - Kokona_2021_Neuropharmacol_185_108450 |
| Author(s) : Kokona D , Spyridakos D , Tzatzarakis M , Papadogkonaki S , Filidou E , Arvanitidis KI , Kolios G , Lamani M , Makriyannis A , Malamas MS , Thermos K |
| Ref : Neuropharmacology , 185 :108450 , 2021 |
| Abstract : |
| PubMedSearch : Kokona_2021_Neuropharmacol_185_108450 |
| PubMedID: 33450278 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors - Malamas_2021_ChemMedChem__ |
| Author(s) : Malamas MS , Lamani M , Farah SI , Mohammad KA , Miyabe CY , Rajarshi G , Wu S , Zvonok N , Chandrashekhar H , Wood J , Makriyannis A |
| Ref : ChemMedChem , : , 2021 |
| Abstract : |
| PubMedSearch : Malamas_2021_ChemMedChem__ |
| PubMedID: 34486233 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System - Zhang_2021_Front.Pharmacol_12_784202 |
| Author(s) : Zhang H , Li X , Liao D , Luo P , Jiang X |
| Ref : Front Pharmacol , 12 :784202 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Front.Pharmacol_12_784202 |
| PubMedID: 34925039 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1 - Farah_2021_Biochem.Biophys.Res.Commun_591_31 |
| Author(s) : Farah SI , Hilston S , Tran N , Zvonok N , Makriyannis A |
| Ref : Biochemical & Biophysical Research Communications , 591 :31 , 2021 |
| Abstract : |
| PubMedSearch : Farah_2021_Biochem.Biophys.Res.Commun_591_31 |
| PubMedID: 34995983 |
| Gene_locus related to this paper: human-ABHD6 , human-MGLL |
| Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000 |
| Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F |
| Ref : Journal of Neurochemistry , :e15000 , 2020 |
| Abstract : |
| PubMedSearch : Longaretti_2020_J.Neurochem__e15000 |
| PubMedID: 32141088 |
| Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL |
| Title : Adipose ABHD6 regulates tolerance to cold and thermogenic programs - Poursharifi_2020_JCI.Insight_5_ |
| Author(s) : Poursharifi P , Attane C , Mugabo Y , Al-Mass A , Ghosh A , Schmitt C , Zhao S , Guida J , Lussier R , Erb H , Chenier I , Peyot ML , Joly E , Noll C , Carpentier AC , Madiraju SRM , Prentki M |
| Ref : JCI Insight , 5 : , 2020 |
| Abstract : |
| PubMedSearch : Poursharifi_2020_JCI.Insight_5_ |
| PubMedID: 33201859 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353 |
| Author(s) : Deng H , Li W |
| Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020 |
| Abstract : |
| PubMedSearch : Deng_2020_Eur.J.Med.Chem_198_112353 |
| PubMedID: 32371333 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta - Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807 |
| Author(s) : Maia J , Fonseca BM , Cunha SC , Braga J , Goncalves D , Teixeira N , Correia-da-Silva G |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , :158807 , 2020 |
| Abstract : |
| PubMedSearch : Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807 |
| PubMedID: 32829065 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans - Grabner_2019_J.Lipid.Res_60_1020 |
| Author(s) : Grabner GF , Fawzy N , Pribasnig MA , Trieb M , Taschler U , Holzer M , Schweiger M , Wolinski H , Kolb D , Horvath A , Breinbauer R , Rulicke T , Rabl R , Lass A , Stadlbauer V , Hutter-Paier B , Stauber RE , Fickert P , Zechner R , Marsche G , Eichmann TO , Zimmermann R |
| Ref : J Lipid Res , 60 :1020 , 2019 |
| Abstract : |
| PubMedSearch : Grabner_2019_J.Lipid.Res_60_1020 |
| PubMedID: 30894461 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : The alpha\/beta-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids - Bottemanne_2019_FASEB.J__fj201802259R |
| Author(s) : Bottemanne P , Paquot A , Ameraoui H , Alhouayek M , Muccioli GG |
| Ref : FASEB Journal , :fj201802259R , 2019 |
| Abstract : |
| PubMedSearch : Bottemanne_2019_FASEB.J__fj201802259R |
| PubMedID: 30896979 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype - Rahaman_2019_J.Immunol_202_1674 |
| Author(s) : Rahaman O , Bhattacharya R , Liu CSC , Raychaudhuri D , Ghosh AR , Bandopadhyay P , Pal S , Goswami RP , Sircar G , Ghosh P , Ganguly D |
| Ref : J Immunol , 202 :1674 , 2019 |
| Abstract : |
| PubMedSearch : Rahaman_2019_J.Immunol_202_1674 |
| PubMedID: 30728209 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells - van Esbroeck_2019_Front.Mol.Neurosci_12_286 |
| Author(s) : van Esbroeck ACM , Kantae V , Di X , van der Wel T , den Dulk H , Stevens AF , Singh S , Bakker AT , Florea BI , Stella N , Overkleeft HS , Hankemeier T , van der Stelt M |
| Ref : Front Mol Neurosci , 12 :286 , 2019 |
| Abstract : |
| PubMedSearch : van Esbroeck_2019_Front.Mol.Neurosci_12_286 |
| PubMedID: 31849602 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Biochemical and Proteomic Characterization of Recombinant Human alpha\/beta Hydrolase Domain 6 - Shields_2019_Sci.Rep_9_890 |
| Author(s) : Shields CM , Zvonok N , Zvonok A , Makriyannis A |
| Ref : Sci Rep , 9 :890 , 2019 |
| Abstract : |
| PubMedSearch : Shields_2019_Sci.Rep_9_890 |
| PubMedID: 30696836 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267 |
| Author(s) : Cao JK , Kaplan J , Stella N |
| Ref : Trends in Pharmacological Sciences , 40 :267 , 2019 |
| Abstract : |
| PubMedSearch : Cao_2019_Trends.Pharmacol.Sci_40_267 |
| PubMedID: 30853109 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells - Drehmer_2019_Biochem.Genet_57_35 |
| Author(s) : Drehmer MN , Muniz YCN , Marrero AR , Lofgren SE |
| Ref : Biochemical Genetics , 57 :35 , 2019 |
| Abstract : |
| PubMedSearch : Drehmer_2019_Biochem.Genet_57_35 |
| PubMedID: 30006903 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337 |
| Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N |
| Ref : J Leukoc Biol , 106 :1337 , 2019 |
| Abstract : |
| PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedID: 31556464 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1 |
| Title : Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease - Kind_2019_Amino.Acids_51_151 |
| Author(s) : Kind L , Kursula P |
| Ref : Amino Acids , 51 :151 , 2018 |
| Abstract : |
| PubMedSearch : Kind_2019_Amino.Acids_51_151 |
| PubMedID: 30564946 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 |
| Title : Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis - Manterola_2018_Neuropharmacol_141_181 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Ruiz A , Perez-Samartin A , Moreno-Rodriguez M , Hsu KL , Cravatt BF , Brown JM , Rodriguez-Puertas R , Matute C , Mato S |
| Ref : Neuropharmacology , 141 :181 , 2018 |
| Abstract : |
| PubMedSearch : Manterola_2018_Neuropharmacol_141_181 |
| PubMedID: 30171986 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination - Manterola_2018_Biochem.Pharmacol_157_189 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Canedo-Antelo M , Moreno-Garcia A , Martin-Fontecha M , Perez-Cerda F , Sanchez-Gomez MV , Ortega-Gutierrez S , Brown JM , Hsu KL , Cravatt B , Matute C , Mato S |
| Ref : Biochemical Pharmacology , 157 :189 , 2018 |
| Abstract : |
| PubMedSearch : Manterola_2018_Biochem.Pharmacol_157_189 |
| PubMedID: 30075103 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases - Baggelaar_2017_ACS.Chem.Biol_12_852 |
| Author(s) : Baggelaar MP , van Esbroeck AC , van Rooden EJ , Florea BI , Overkleeft HS , Marsicano G , Chaouloff F , van der Stelt M |
| Ref : ACS Chemical Biology , 12 :852 , 2017 |
| Abstract : |
| PubMedSearch : Baggelaar_2017_ACS.Chem.Biol_12_852 |
| PubMedID: 28106377 |
| Gene_locus related to this paper: human-ABHD4 , human-ABHD6 , human-ABHD12 , human-DAGLA , human-MGLL |
| Title : Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors - Deng_2017_Medchemcomm_8_982 |
| Author(s) : Deng H , van der Wel T , van den Berg R , van den Nieuwendijk A , Janssen FJ , Baggelaar MP , Overkleeft HS , van der Stelt M |
| Ref : Medchemcomm , 8 :982 , 2017 |
| Abstract : |
| PubMedSearch : Deng_2017_Medchemcomm_8_982 |
| PubMedID: 30108813 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872 |
| Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M |
| Ref : Cell Rep , 14 :2872 , 2016 |
| Abstract : |
| PubMedSearch : Zhao_2016_Cell.Rep_14_2872 |
| PubMedID: 26997277 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors - Wei_2016_Proc.Natl.Acad.Sci.U.S.A_113_E2695 |
| Author(s) : Wei M , Zhang J , Jia M , Yang C , Pan Y , Li S , Luo Y , Zheng J , Ji J , Chen J , Hu X , Xiong J , Shi Y , Zhang C |
| Ref : Proc Natl Acad Sci U S A , 113 :E2695 , 2016 |
| Abstract : |
| PubMedSearch : Wei_2016_Proc.Natl.Acad.Sci.U.S.A_113_E2695 |
| PubMedID: 27114538 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility - Fisette_2016_Cell.Rep_17_1217 |
| Author(s) : Fisette A , Tobin S , Decarie-Spain L , Bouyakdan K , Peyot ML , Madiraju SR , Prentki M , Fulton S , Alquier T |
| Ref : Cell Rep , 17 :1217 , 2016 |
| Abstract : |
| PubMedSearch : Fisette_2016_Cell.Rep_17_1217 |
| PubMedID: 27783937 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal\/Lysosomal Lipid Bis(monoacylglycero)phosphate - Pribasnig_2015_J.Biol.Chem_290_29869 |
| Author(s) : Pribasnig MA , Mrak I , Grabner GF , Taschler U , Knittelfelder O , Scherz B , Eichmann TO , Heier C , Grumet L , Kowaliuk J , Romauch M , Holler S , Anderl F , Wolinski H , Lass A , Breinbauer R , Marsche G , Brown JM , Zimmermann R |
| Ref : Journal of Biological Chemistry , 290 :29869 , 2015 |
| Abstract : |
| PubMedSearch : Pribasnig_2015_J.Biol.Chem_290_29869 |
| PubMedID: 26491015 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253 |
| Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T |
| Ref : ChemMedChem , 10 :253 , 2015 |
| Abstract : |
| PubMedSearch : Patel_2015_ChemMedChem_10_253 |
| PubMedID: 25504894 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : alpha\/beta-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli - Zhao_2015_Mol.Metab_4_940 |
| Author(s) : Zhao S , Poursharifi P , Mugabo Y , Levens EJ , Vivot K , Attane C , Iglesias J , Peyot ML , Joly E , Madiraju SR , Prentki M |
| Ref : Mol Metab , 4 :940 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_Mol.Metab_4_940 |
| PubMedID: 26909310 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family - Thomas_2014_Biochim.Biophys.Acta_1841_1097 |
| Author(s) : Thomas G , Brown AL , Brown JM |
| Ref : Biochimica & Biophysica Acta , 1841 :1097 , 2014 |
| Abstract : |
| PubMedSearch : Thomas_2014_Biochim.Biophys.Acta_1841_1097 |
| PubMedID: 24423940 |
| Gene_locus related to this paper: human-ABHD3 , human-ABHD6 , human-ABHD12 |
| Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361 |
| Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N |
| Ref : Neuron , 83 :361 , 2014 |
| Abstract : |
| PubMedSearch : Naydenov_2014_Neuron_83_361 |
| PubMedID: 25033180 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522 |
| Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT |
| Ref : Molecular Pharmacology , 86 :522 , 2014 |
| Abstract : |
| PubMedSearch : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedID: 25140003 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome - Thomas_2013_Cell.Rep_5_508 |
| Author(s) : Thomas G , Betters JL , Lord CC , Brown AL , Marshall S , Ferguson D , Sawyer J , Davis MA , Melchior JT , Blume LC , Howlett AC , Ivanova PT , Milne SB , Myers DS , Mrak I , Leber V , Heier C , Taschler U , Blankman JL , Cravatt BF , Lee RG , Crooke RM , Graham MJ , Zimmermann R , Brown HA , Brown JM |
| Ref : Cell Rep , 5 :508 , 2013 |
| Abstract : |
| PubMedSearch : Thomas_2013_Cell.Rep_5_508 |
| PubMedID: 24095738 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Highly predictive ligand-based pharmacophore and homology models of ABHD6 - Bowman_2013_Chem.Biol.Drug.Des_81_382 |
| Author(s) : Bowman AL , Makriyannis A |
| Ref : Chemical Biology Drug Des , 81 :382 , 2013 |
| Abstract : |
| PubMedSearch : Bowman_2013_Chem.Biol.Drug.Des_81_382 |
| PubMedID: 23110439 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6 - Alhouayek_2013_Proc.Natl.Acad.Sci.U.S.A_110_17558 |
| Author(s) : Alhouayek M , Masquelier J , Cani PD , Lambert DM , Muccioli GG |
| Ref : Proc Natl Acad Sci U S A , 110 :17558 , 2013 |
| Abstract : |
| PubMedSearch : Alhouayek_2013_Proc.Natl.Acad.Sci.U.S.A_110_17558 |
| PubMedID: 24101490 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) - Hsu_2012_Probe.Report__ |
| Author(s) : Hsu KL , Tsuboi K , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2012 |
| Abstract : |
| PubMedSearch : Hsu_2012_Probe.Report__ |
| PubMedID: 23658950 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Biochemical and pharmacological characterization of human alpha\/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) - Navia-Paldanius_2012_J.Lipid.Res_53_2413 |
| Author(s) : Navia-Paldanius D , Savinainen JR , Laitinen JT |
| Ref : J Lipid Res , 53 :2413 , 2012 |
| Abstract : |
| PubMedSearch : Navia-Paldanius_2012_J.Lipid.Res_53_2413 |
| PubMedID: 22969151 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 |
| Title : The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors - Savinainen_2012_Acta.Physiol.(Oxf)_204_267 |
| Author(s) : Savinainen JR , Saario SM , Laitinen JT |
| Ref : Acta Physiol (Oxf) , 204 :267 , 2012 |
| Abstract : |
| PubMedSearch : Savinainen_2012_Acta.Physiol.(Oxf)_204_267 |
| PubMedID: 21418147 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone - Matuszak_2011_Bioorg.Med.Chem.Lett_21_7321 |
| Author(s) : Matuszak N , Es Saadi B , Labar G , Marchand-Brynaert J , Lambert DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :7321 , 2011 |
| Abstract : |
| PubMedSearch : Matuszak_2011_Bioorg.Med.Chem.Lett_21_7321 |
| PubMedID: 22056744 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Dual inhibition of alpha\/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons - Marrs_2011_J.Biol.Chem_286_28723 |
| Author(s) : Marrs WR , Horne EA , Ortega-Gutierrez S , Cisneros JA , Xu C , Lin YH , Muccioli GG , Lopez-Rodriguez ML , Stella N |
| Ref : Journal of Biological Chemistry , 286 :28723 , 2011 |
| Abstract : |
| PubMedSearch : Marrs_2011_J.Biol.Chem_286_28723 |
| PubMedID: 21665953 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951 |
| Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N |
| Ref : Nat Neurosci , 13 :951 , 2010 |
| Abstract : |
| PubMedSearch : Marrs_2010_Nat.Neurosci_13_951 |
| PubMedID: 20657592 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors - King_2009_Br.J.Pharmacol_157_974 |
| Author(s) : King AR , Lodola A , Carmi C , Fu J , Mor M , Piomelli D |
| Ref : British Journal of Pharmacology , 157 :974 , 2009 |
| Abstract : |
| PubMedSearch : King_2009_Br.J.Pharmacol_157_974 |
| PubMedID: 19486005 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : High expression of the evolutionarily conserved alpha\/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors - Max_2009_Cancer.Sci_100_2383 |
| Author(s) : Max D , Hesse M , Volkmer I , Staege MS |
| Ref : Cancer Sci , 100 :2383 , 2009 |
| Abstract : |
| PubMedSearch : Max_2009_Cancer.Sci_100_2383 |
| PubMedID: 19793082 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : An unannotated alpha\/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines - Li_2009_Mol.Biol.Rep_36_691 |
| Author(s) : Li F , Fei X , Xu J , Ji C |
| Ref : Mol Biol Rep , 36 :691 , 2009 |
| Abstract : |
| PubMedSearch : Li_2009_Mol.Biol.Rep_36_691 |
| PubMedID: 18360779 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347 |
| Author(s) : Blankman JL , Simon GM , Cravatt BF |
| Ref : Chemical Biology , 14 :1347 , 2007 |
| Abstract : |
| PubMedSearch : Blankman_2007_Chem.Biol_14_1347 |
| PubMedID: 18096503 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |