ABHD6-Lip
Relationship
Comment
Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzyme hydrolyzing 26AG (belongs to Monoglyceridelipase_lysophospholip family). 
. Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity. ABHD6 hydrolyzes Bis(monoacylglycerol)phosphate (BMP): a phospholipid crucial for lipid degradation and sorting in acidic organelles and accumulating in Lysosomal storage disorders Pribasnig et al. ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999 Membrane phospholipid remodeling by a bacterial Lands cycle phospholipase A is published by Bleffert et al. PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. (6I8W). Main substrates include: diacylglycerols, 1(3)-monoacylglycerols with saturated medium or long acyl chains, 2-arachidonoylglycerol, lysophosphatidylinositols, bis(monoacylglycero)phosphate. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility Wei et al.
Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Structures (4)
Genes Proteins in ABHD6-Lip family (156)
Fragments of genes in ABHD6-Lip family (3)
Structures in ABHD6-Lip family (4)Substrates in ABHD6-Lip family (11)
Inhibitors in ABHD6-Lip family (34)
References (29)
| Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559 |
| Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C |
| Ref : Prog Neurobiol , :102559 , 2023 |
| PubMedID: 38159878 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822 |
| Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M |
| Ref : Mol Metab , :101822 , 2023 |
| PubMedID: 37838014 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099 |
| Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N |
| Ref : Neurobiol Dis , 180 :106099 , 2023 |
| PubMedID: 36990366 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status - Miralpeix_2021_Br.J.Pharmacol_178_1507 |
| Author(s) : Miralpeix C , Reguera AC , Fosch A , Casas M , Lillo J , Navarro G , Franco R , Casas J , Alexander SPH , Casals N , Rodriguez-Rodriguez R |
| Ref : British Journal of Pharmacology , 178 :1507 , 2021 |
| PubMedID: 33444462 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System - Zhang_2021_Front.Pharmacol_12_784202 |
| Author(s) : Zhang H , Li X , Liao D , Luo P , Jiang X |
| Ref : Front Pharmacol , 12 :784202 , 2021 |
| PubMedID: 34925039 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Evidence for a bacterial Lands cycle phospholipase A: Structural and mechanistic insights into membrane phospholipid remodeling - Bleffert_2021_Biorxiv__ |
| Author(s) : Bleffert F , Granzin J , Caliskan M , Schott-Verdugo SN , Siebers M , Thiele B , Rahme L , Felgner S , Dormann P , Gohlke H , Batra-Safferling R , Jaeger KE , Kovacic F |
| Ref : Biorxiv , : , 2021 |
| PubMedID: |
| Gene_locus related to this paper: pseae-PA2949 |
| Title : Adipose ABHD6 regulates tolerance to cold and thermogenic programs - Poursharifi_2020_JCI.Insight_5_ |
| Author(s) : Poursharifi P , Attane C , Mugabo Y , Al-Mass A , Ghosh A , Schmitt C , Zhao S , Guida J , Lussier R , Erb H , Chenier I , Peyot ML , Joly E , Noll C , Carpentier AC , Madiraju SRM , Prentki M |
| Ref : JCI Insight , 5 : , 2020 |
| PubMedID: 33201859 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353 |
| Author(s) : Deng H , Li W |
| Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020 |
| PubMedID: 32371333 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans - Grabner_2019_J.Lipid.Res_60_1020 |
| Author(s) : Grabner GF , Fawzy N , Pribasnig MA , Trieb M , Taschler U , Holzer M , Schweiger M , Wolinski H , Kolb D , Horvath A , Breinbauer R , Rulicke T , Rabl R , Lass A , Stadlbauer V , Hutter-Paier B , Stauber RE , Fickert P , Zechner R , Marsche G , Eichmann TO , Zimmermann R |
| Ref : J Lipid Res , 60 :1020 , 2019 |
| PubMedID: 30894461 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : The alpha\/beta-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids - Bottemanne_2019_FASEB.J__fj201802259R |
| Author(s) : Bottemanne P , Paquot A , Ameraoui H , Alhouayek M , Muccioli GG |
| Ref : FASEB Journal , :fj201802259R , 2019 |
| PubMedID: 30896979 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype - Rahaman_2019_J.Immunol_202_1674 |
| Author(s) : Rahaman O , Bhattacharya R , Liu CSC , Raychaudhuri D , Ghosh AR , Bandopadhyay P , Pal S , Goswami RP , Sircar G , Ghosh P , Ganguly D |
| Ref : J Immunol , 202 :1674 , 2019 |
| PubMedID: 30728209 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells - van Esbroeck_2019_Front.Mol.Neurosci_12_286 |
| Author(s) : van Esbroeck ACM , Kantae V , Di X , van der Wel T , den Dulk H , Stevens AF , Singh S , Bakker AT , Florea BI , Stella N , Overkleeft HS , Hankemeier T , van der Stelt M |
| Ref : Front Mol Neurosci , 12 :286 , 2019 |
| PubMedID: 31849602 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Biochemical and Proteomic Characterization of Recombinant Human alpha\/beta Hydrolase Domain 6 - Shields_2019_Sci.Rep_9_890 |
| Author(s) : Shields CM , Zvonok N , Zvonok A , Makriyannis A |
| Ref : Sci Rep , 9 :890 , 2019 |
| PubMedID: 30696836 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267 |
| Author(s) : Cao JK , Kaplan J , Stella N |
| Ref : Trends in Pharmacological Sciences , 40 :267 , 2019 |
| PubMedID: 30853109 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease - Kind_2019_Amino.Acids_51_151 |
| Author(s) : Kind L , Kursula P |
| Ref : Amino Acids , 51 :151 , 2018 |
| PubMedID: 30564946 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 |
| Title : The Inhibitory Effect of alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors - Wei_2017_Front.Mol.Neurosci_10_55 |
| Author(s) : Wei M , Jia M , Zhang J , Yu L , Zhao Y , Chen Y , Ma Y , Zhang W , Shi YS , Zhang C |
| Ref : Front Mol Neurosci , 10 :55 , 2017 |
| PubMedID: 28303090 |
| Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872 |
| Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M |
| Ref : Cell Rep , 14 :2872 , 2016 |
| PubMedID: 26997277 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors - Wei_2016_Proc.Natl.Acad.Sci.U.S.A_113_E2695 |
| Author(s) : Wei M , Zhang J , Jia M , Yang C , Pan Y , Li S , Luo Y , Zheng J , Ji J , Chen J , Hu X , Xiong J , Shi Y , Zhang C |
| Ref : Proc Natl Acad Sci U S A , 113 :E2695 , 2016 |
| PubMedID: 27114538 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : alpha\/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal\/Lysosomal Lipid Bis(monoacylglycero)phosphate - Pribasnig_2015_J.Biol.Chem_290_29869 |
| Author(s) : Pribasnig MA , Mrak I , Grabner GF , Taschler U , Knittelfelder O , Scherz B , Eichmann TO , Heier C , Grumet L , Kowaliuk J , Romauch M , Holler S , Anderl F , Wolinski H , Lass A , Breinbauer R , Marsche G , Brown JM , Zimmermann R |
| Ref : Journal of Biological Chemistry , 290 :29869 , 2015 |
| PubMedID: 26491015 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257 |
| Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013 |
| PubMedID: 24152245 |
| Gene_locus related to this paper: human-DAGLB |
| Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270 |
| Author(s) : Hsu KL , Tsuboi K , Chang JW , Whitby LR , Speers AE , Pugh H , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8270 , 2013 |
| PubMedID: 24152295 |
| Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951 |
| Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N |
| Ref : Nat Neurosci , 13 :951 , 2010 |
| PubMedID: 20657592 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : High expression of the evolutionarily conserved alpha\/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors - Max_2009_Cancer.Sci_100_2383 |
| Author(s) : Max D , Hesse M , Volkmer I , Staege MS |
| Ref : Cancer Sci , 100 :2383 , 2009 |
| PubMedID: 19793082 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : An unannotated alpha\/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines - Li_2009_Mol.Biol.Rep_36_691 |
| Author(s) : Li F , Fei X , Xu J , Ji C |
| Ref : Mol Biol Rep , 36 :691 , 2009 |
| PubMedID: 18360779 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347 |
| Author(s) : Blankman JL , Simon GM , Cravatt BF |
| Ref : Chemical Biology , 14 :1347 , 2007 |
| PubMedID: 18096503 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Cloning, expression and characterization of a lipase gene (lip3) from Pseudomonas aeruginosa LST-03 - Ogino_2004_Mol.Genet.Genomics_271_189 |
| Author(s) : Ogino H , Hiroshima S , Hirose S , Yasuda M , Ishimi K , Ishikawa H |
| Ref : Mol Genet Genomics , 271 :189 , 2004 |
| PubMedID: 14740297 |
| Gene_locus related to this paper: pseae-PA2949 |
| Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390 |
| Author(s) : Jaeger KE , Eggert T |
| Ref : Curr Opin Biotechnol , 13 :390 , 2002 |
| PubMedID: 12323363 |
| Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177 |
| Author(s) : Arpigny JL , Jaeger KE |
| Ref : Biochemical Journal , 343 :177 , 1999 |
| PubMedID: 10493927 |
| Title : Nucleotide sequence of the lipase gene lip3 from the antarctic psychotroph Moraxella TA144 - Feller_1991_Biochim.Biophys.Acta_1088_323 |
| Author(s) : Feller G , Thiry M , Gerday C |
| Ref : Biochimica & Biophysica Acta , 1088 :323 , 1991 |
| PubMedID: 2001407 |
| Gene_locus related to this paper: morsp-3lipa |