ABHD6-Lip

Relationship

Family: ABHD6-Lip

Block: X

Parent Family: Epoxide-hydrolase_like

Comment

Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzyme hydrolyzing 26AG (belongs to Monoglyceridelipase_lysophospholip family). . Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity. ABHD6 hydrolyzes Bis(monoacylglycerol)phosphate (BMP): a phospholipid crucial for lipid degradation and sorting in acidic organelles and accumulating in Lysosomal storage disorders Pribasnig et al. ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999 Membrane phospholipid remodeling by a bacterial Lands cycle phospholipase A is published by Bleffert et al. PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. (6I8W). Main substrates include: diacylglycerols, 1(3)-monoacylglycerols with saturated medium or long acyl chains, 2-arachidonoylglycerol, lysophosphatidylinositols, bis(monoacylglycero)phosphate. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility Wei et al.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (4)

Genes Proteins in ABHD6-Lip family (156)

Fragments of genes in ABHD6-Lip family (3)

Structures in ABHD6-Lip family (4)

Substrates in ABHD6-Lip family (11)

Inhibitors in ABHD6-Lip family (34)

References (29)

Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559
Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C
Ref : Prog Neurobiol , :102559 , 2023
PubMedID: 38159878
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822
Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M
Ref : Mol Metab , :101822 , 2023
PubMedID: 37838014
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099
Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N
Ref : Neurobiol Dis , 180 :106099 , 2023
PubMedID: 36990366
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Evidence for a bacterial Lands cycle phospholipase A: Structural and mechanistic insights into membrane phospholipid remodeling - Bleffert_2021_Biorxiv__
Author(s) : Bleffert F , Granzin J , Caliskan M , Schott-Verdugo SN , Siebers M , Thiele B , Rahme L , Felgner S , Dormann P , Gohlke H , Batra-Safferling R , Jaeger KE , Kovacic F
Ref : Biorxiv , : , 2021
PubMedID:
Gene_locus related to this paper: pseae-PA2949

Title : Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status - Miralpeix_2021_Br.J.Pharmacol_178_1507
Author(s) : Miralpeix C , Reguera AC , Fosch A , Casas M , Lillo J , Navarro G , Franco R , Casas J , Alexander SPH , Casals N , Rodriguez-Rodriguez R
Ref : British Journal of Pharmacology , 178 :1507 , 2021
PubMedID: 33444462
Gene_locus related to this paper: human-ABHD6

Title : Alpha\/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System - Zhang_2021_Front.Pharmacol_12_784202
Author(s) : Zhang H , Li X , Liao D , Luo P , Jiang X
Ref : Front Pharmacol , 12 :784202 , 2021
PubMedID: 34925039
Gene_locus related to this paper: human-ABHD6

Title : Adipose ABHD6 regulates tolerance to cold and thermogenic programs - Poursharifi_2020_JCI.Insight_5_
Author(s) : Poursharifi P , Attane C , Mugabo Y , Al-Mass A , Ghosh A , Schmitt C , Zhao S , Guida J , Lussier R , Erb H , Chenier I , Peyot ML , Joly E , Noll C , Carpentier AC , Madiraju SRM , Prentki M
Ref : JCI Insight , 5 : , 2020
PubMedID: 33201859
Gene_locus related to this paper: human-ABHD6

Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353
Author(s) : Deng H , Li W
Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020
PubMedID: 32371333
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans - Grabner_2019_J.Lipid.Res_60_1020
Author(s) : Grabner GF , Fawzy N , Pribasnig MA , Trieb M , Taschler U , Holzer M , Schweiger M , Wolinski H , Kolb D , Horvath A , Breinbauer R , Rulicke T , Rabl R , Lass A , Stadlbauer V , Hutter-Paier B , Stauber RE , Fickert P , Zechner R , Marsche G , Eichmann TO , Zimmermann R
Ref : J Lipid Res , 60 :1020 , 2019
PubMedID: 30894461
Gene_locus related to this paper: human-ABHD6

Title : The alpha\/beta-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids - Bottemanne_2019_FASEB.J__fj201802259R
Author(s) : Bottemanne P , Paquot A , Ameraoui H , Alhouayek M , Muccioli GG
Ref : FASEB Journal , :fj201802259R , 2019
PubMedID: 30896979
Gene_locus related to this paper: human-ABHD6

Title : Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype - Rahaman_2019_J.Immunol_202_1674
Author(s) : Rahaman O , Bhattacharya R , Liu CSC , Raychaudhuri D , Ghosh AR , Bandopadhyay P , Pal S , Goswami RP , Sircar G , Ghosh P , Ganguly D
Ref : J Immunol , 202 :1674 , 2019
PubMedID: 30728209
Gene_locus related to this paper: human-ABHD6

Title : Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells - van Esbroeck_2019_Front.Mol.Neurosci_12_286
Author(s) : van Esbroeck ACM , Kantae V , Di X , van der Wel T , den Dulk H , Stevens AF , Singh S , Bakker AT , Florea BI , Stella N , Overkleeft HS , Hankemeier T , van der Stelt M
Ref : Front Mol Neurosci , 12 :286 , 2019
PubMedID: 31849602
Gene_locus related to this paper: human-ABHD6

Title : Biochemical and Proteomic Characterization of Recombinant Human alpha\/beta Hydrolase Domain 6 - Shields_2019_Sci.Rep_9_890
Author(s) : Shields CM , Zvonok N , Zvonok A , Makriyannis A
Ref : Sci Rep , 9 :890 , 2019
PubMedID: 30696836
Gene_locus related to this paper: human-ABHD6

Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267
Author(s) : Cao JK , Kaplan J , Stella N
Ref : Trends in Pharmacological Sciences , 40 :267 , 2019
PubMedID: 30853109
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease - Kind_2019_Amino.Acids_51_151
Author(s) : Kind L , Kursula P
Ref : Amino Acids , 51 :151 , 2018
PubMedID: 30564946
Gene_locus related to this paper: human-ABHD6 , human-ABHD12

Title : The Inhibitory Effect of alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors - Wei_2017_Front.Mol.Neurosci_10_55
Author(s) : Wei M , Jia M , Zhang J , Yu L , Zhao Y , Chen Y , Ma Y , Zhang W , Shi YS , Zhang C
Ref : Front Mol Neurosci , 10 :55 , 2017
PubMedID: 28303090

Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872
Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M
Ref : Cell Rep , 14 :2872 , 2016
PubMedID: 26997277
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors - Wei_2016_Proc.Natl.Acad.Sci.U.S.A_113_E2695
Author(s) : Wei M , Zhang J , Jia M , Yang C , Pan Y , Li S , Luo Y , Zheng J , Ji J , Chen J , Hu X , Xiong J , Shi Y , Zhang C
Ref : Proc Natl Acad Sci U S A , 113 :E2695 , 2016
PubMedID: 27114538
Gene_locus related to this paper: human-ABHD6

Title : alpha\/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal\/Lysosomal Lipid Bis(monoacylglycero)phosphate - Pribasnig_2015_J.Biol.Chem_290_29869
Author(s) : Pribasnig MA , Mrak I , Grabner GF , Taschler U , Knittelfelder O , Scherz B , Eichmann TO , Heier C , Grumet L , Kowaliuk J , Romauch M , Holler S , Anderl F , Wolinski H , Lass A , Breinbauer R , Marsche G , Brown JM , Zimmermann R
Ref : Journal of Biological Chemistry , 290 :29869 , 2015
PubMedID: 26491015
Gene_locus related to this paper: human-ABHD6

Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270
Author(s) : Hsu KL , Tsuboi K , Chang JW , Whitby LR , Speers AE , Pugh H , Cravatt BF
Ref : Journal of Medicinal Chemistry , 56 :8270 , 2013
PubMedID: 24152295

Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257
Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF
Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013
PubMedID: 24152245
Gene_locus related to this paper: human-DAGLB

Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951
Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N
Ref : Nat Neurosci , 13 :951 , 2010
PubMedID: 20657592
Gene_locus related to this paper: human-ABHD6

Title : High expression of the evolutionarily conserved alpha\/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors - Max_2009_Cancer.Sci_100_2383
Author(s) : Max D , Hesse M , Volkmer I , Staege MS
Ref : Cancer Sci , 100 :2383 , 2009
PubMedID: 19793082
Gene_locus related to this paper: human-ABHD6

Title : An unannotated alpha\/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines - Li_2009_Mol.Biol.Rep_36_691
Author(s) : Li F , Fei X , Xu J , Ji C
Ref : Mol Biol Rep , 36 :691 , 2009
PubMedID: 18360779
Gene_locus related to this paper: human-ABHD6

Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347
Author(s) : Blankman JL , Simon GM , Cravatt BF
Ref : Chemical Biology , 14 :1347 , 2007
PubMedID: 18096503
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : Cloning, expression and characterization of a lipase gene (lip3) from Pseudomonas aeruginosa LST-03 - Ogino_2004_Mol.Genet.Genomics_271_189
Author(s) : Ogino H , Hiroshima S , Hirose S , Yasuda M , Ishimi K , Ishikawa H
Ref : Mol Genet Genomics , 271 :189 , 2004
PubMedID: 14740297
Gene_locus related to this paper: pseae-PA2949

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
PubMedID: 12323363

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
Author(s) : Arpigny JL , Jaeger KE
Ref : Biochemical Journal , 343 :177 , 1999
PubMedID: 10493927

Title : Nucleotide sequence of the lipase gene lip3 from the antarctic psychotroph Moraxella TA144 - Feller_1991_Biochim.Biophys.Acta_1088_323
Author(s) : Feller G , Thiry M , Gerday C
Ref : Biochimica & Biophysica Acta , 1088 :323 , 1991
PubMedID: 2001407
Gene_locus related to this paper: morsp-3lipa