ABHD6-Lip

Relationship

Family: ABHD6-Lip

Block: X

Parent Family: Epoxide-hydrolase_like

Comment

Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzyme hydrolyzing 26AG (belongs to Monoglyceridelipase_lysophospholip family). . Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity. ABHD6 hydrolyzes Bis(monoacylglycerol)phosphate (BMP): a phospholipid crucial for lipid degradation and sorting in acidic organelles and accumulating in Lysosomal storage disorders Pribasnig et al. ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999 Membrane phospholipid remodeling by a bacterial Lands cycle phospholipase A is published by Bleffert et al. PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. (6I8W). Main substrates include: diacylglycerols, 1(3)-monoacylglycerols with saturated medium or long acyl chains, 2-arachidonoylglycerol, lysophosphatidylinositols, bis(monoacylglycero)phosphate. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility Wei et al.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
7OTS Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside human-ABHD6
6I8W Crystal structure of a membrane phospholipase A from Pseudomonas aeruginosa, a novel bacterial virulence factor pseae-PA2949
4OPM Crystal structure of a putative lipase (lip1) from Acinetobacter baumannii AYE at 1.70 A resolution aciba-k6lkl9
4NS4 Crystal structure of cold-active esterase from Psychrobacter cryohalolentis K5 psyck-q1qeu6

Gene_locus Name Species
9gamm-g6yq95 Marinobacter flavimaris\; Marinobacter adhaerens\; Marinobacter manganoxydans, esterase Est1347 Marinobacter flavimaris
alcbs-q0vqa3 Alcanivorax borkumensis (strain ATCC 700651 \/ DSM 11573 \/ NCIMB 13689 \/ SK2) EH128 Carboxylic ester hydrolase Alcanivorax borkumensis SK2
9zzzz-a0a0g3fh19 uncultured organism EH122 Uncharacterized protein uncultured organism
9bact-a0a1s5ql22 uncultured bacterium EH114 Alpha\/beta hydrolase fold carboxyl esterase uncultured bacterium
9zzzz-a0a0g3fkz8 uncultured organism EH104 Uncharacterized protein uncultured organism
9zzzz-a0a0g3fei1 uncultured organism EH81 Uncharacterized protein uncultured organism
9bact-a0a1s5qly6 uncultured bacterium EH65 Alpha\/beta hydrolase fold carboxyl esterase uncultured bacterium
9alte-a3j8t5 Marinobacter sp. ELB17 Predicted Hydrolase or acyltransferase (Alpha\/beta hydrolase superfamily) protein Marinobacter sp. ELB17
9alte-h3zi43 Alishewanella jeotgali KCTC 22429 Lipase Alishewanella jeotgali KCTC 22429
9alte-m1faq0 Marinobacter sp. BSs20148 Lipase 3 Marinobacter sp. BSs20148
9alte-n6wxm5 Marinobacter nanhaiticus D15-8W Abhydrolase domain-containing protein 6 Marinobacter nanhaiticus D15-8W
9alte-r8b447 Marinobacter lipolyticus SM19 Alpha\/beta hydrolase Marinobacter lipolyticus SM19
capte-r7t7t5 Capitella teleta Uncharacterized protein Capitella teleta
capte-r7tx98 Capitella teleta Uncharacterized protein Capitella teleta
capte-r7ua57 Capitella teleta Uncharacterized protein Capitella teleta
capte-r7ua73 Capitella teleta Uncharacterized protein Capitella teleta
9bact-d8v1i7 uncultured bacterium Esterase\/lipase MhpC clone EM3L3 uncultured bacterium
9bact-q1m315 uncultured soil bacterium triacylglycerol lipase (EC 3.1.1.3) uncultured soil bacterium
9bact-q5i686 symbiont bacterium of Paederus fuscipes pedq symbiont bacterium of Paederus fuscipes
9bact-r9qzf7 uncultured bacterium EH55 Hybrid C-C meta-cleavage hydrolase-carboxylesterase uncultured bacterium
9brad-q35a75 Bradyrhizobium sp. BTAi1 probable lipase Bradyrhizobium sp. BTAi1
9burk-a6gnd0 Limnobacter sp. MED105 Putative lipase Limnobacter sp. MED105
9gamm-b5jx61 gamma proteobacterium HTCC5015 Lipase 3, putative gamma proteobacterium HTCC5015
9gamm-i4vny4 Rhodanobacter sp. 115 Alpha\/beta hydrolase Rhodanobacter sp. 115
9gamm-i4vr63 Rhodanobacter fulvus Jip2 Alpha\/beta hydrolase Rhodanobacter fulvus Jip2
9gamm-i4wcv0 Rhodanobacter thiooxydans LCS2 Alpha\/beta hydrolase Rhodanobacter thiooxydans LCS2
9gamm-m5dq85 Thalassolituus oleivorans MIL-1 Carboxylesterase Thalassolituus oleivorans MIL-1
9gamm-n8q9e0 Acinetobacter sp. ANC 3994 Uncharacterized protein Acinetobacter sp. ANC 3994
9gamm-n9djx8 Acinetobacter bouvetii DSM 14964 = CIP 107468 Uncharacterized protein Acinetobacter bouvetii DSM 14964 = CIP 107468
9gamm-q1n052 Oceanobacter sp. RED65 AlphaBeta_hydrolase superfamily protein Oceanobacter sp. RED65
9gamm-q2ktb4 Psychrobacter sp. 7195 triacylglycerol lipase (EC 3.1.1.3) Psychrobacter sp. 7195
9gamm-r1igh2 Grimontia sp. AK16 Alpha\/beta hydrolase fold protein Grimontia sp. AK16
9lept-h2cht8 Leptonema illini DSM 21528 Alpha\/beta hydrolase fold containing protein Leptonema illini DSM 21528
9lept-i0xnk5 Leptospira licerasiae serovar Varillal str. VAR 010 Alpha\/beta hydrolase family protein Leptospira licerasiae serovar Varillal str. VAR 010
9lept-m6dkc4 Leptospira sp. B5-022 Alpha\/beta hydrolase family protein Leptospira sp. B5-022
9lept-n1vn52 Leptospira terpstrae serovar Hualin str. LT 11-33 = ATCC 700639 Alpha\/beta hydrolase family protein Leptospira terpstrae serovar Hualin str. LT 11-33 = ATCC 700639
9lept-n1wa55 Leptospira vanthielii serovar Holland str. Waz Holland = ATCC 700522 Alpha\/beta hydrolase family protein Leptospira vanthielii serovar Holland str. Waz Holland = ATCC 700522
9lept-r8zx46 Leptospira yanagawae serovar Saopaulo str. Sao Paulo = ATCC 700523 Alpha\/beta hydrolase family protein Leptospira yanagawae serovar Saopaulo str. Sao Paulo = ATCC 700523
9lept-r9a4g5 Leptospira wolbachii serovar Codice str. CDC Alpha\/beta hydrolase family protein Leptospira wolbachii serovar Codice str. CDC
9lept-s3ul62 Leptospira wolffii serovar Khorat str. Khorat-H2 Alpha\/beta hydrolase family protein Leptospira wolffii serovar Khorat str. Khorat-H2
9lept-s3v4s9 Leptospira fainei serovar Hurstbridge str. BUT 6 Alpha\/beta hydrolase family protein Leptospira fainei serovar Hurstbridge str. BUT 6
9sphn-n9uyg5 Sphingopyxis sp. MC1 Alpha\/beta hydrolase Sphingopyxis sp. MC1
9zzzz-d0vym9 uncultured microorganism Putative uncharacterized protein uncultured microorganism
9zzzz-m1p1l5 uncultured organism Alpha\/beta superfamily hydrolase\/acyltransferase uncultured organism
aciad-q6fd56 Acinetobacter sp. (strain ADP1) lipase (EC 3.1.1.3) Acinetobacter sp.
aciba-k6lkl9 Acinetobacter baumannii OIFC099 Alpha\/beta hydrolase family protein Acinetobacter baumannii OIFC099
acicp-f0kgu1 Acinetobacter calcoaceticus (strain PHEA-2) Lipase Acinetobacter calcoaceticus
acig3-n9g6y3 Acinetobacter pittii ANC 3678 Uncharacterized protein Acinetobacter pittii ANC 3678
ailme-d2gx08 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
ampqe-i1gj81 Amphimedon queenslandica (Sponge) Uncharacterized protein Amphimedon queenslandica
anoca-g1k9z1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
anoca-g1kln1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
anoca-g1klq2 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
anoca-r4gan7 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
anoca-r4gdd2 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
bosmu-l8ic43 Bos grunniens mutus Monoacylglycerol lipase ABHD6 Bos grunniens mutus
bovin-q1lz86 Bos taurus (Bovine) similar to abhydrolase domain containing 6 Bos taurus
brafl-c3zci7 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3zlg0 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3zlg2 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3zlg3 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
calja-f6r5u3 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
canfa-e2qvk3 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
cavpo-h0uwi9 Cavia porcellus (Guinea pig) Uncharacterized protein Cavia porcellus
chemy-m7biy2 Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Monoacylglycerol lipase ABHD6 Chelonia mydas
chick-e1c7p7 Gallus gallus (Chicken) Uncharacterized protein Gallus gallus
crigr-g3hfm0 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Monoacylglycerol lipase ABHD6 Cricetulus griseus
danre-e7f881 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein Danio rerio
danre-e9qd39 Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing 6, acylglycerol lipase b Danio rerio
felca-m3w623 Felis catus (Cat) (Felis silvestris catus) Uncharacterized protein Felis catus
gasac-g3ne81 Gasterosteus aculeatus (Three-spined stickleback) Uncharacterized protein Gasterosteus aculeatus
gasac-g3nik5 Gasterosteus aculeatus (Three-spined stickleback) Uncharacterized protein Gasterosteus aculeatus
geosf-b9m8b8 Geobacter sp. (strain FRC-32) Alpha\/beta hydrolase fold protein Geobacter sp.
gorgo-g3rid6 Gorilla gorilla gorilla (Lowland gorilla) Uncharacterized protein Gorilla gorilla gorilla
hahch-q2sq02 Hahella chejuensis (strain KCTC 2396) Predicted Hydrolase or acyltransferase (Alpha\/beta hydrolase superfamily) Hahella chejuensis
hetga-g5bul0 Heterocephalus glaber (Naked mole rat) Monoacylglycerol lipase ABHD6 Heterocephalus glaber
horse-f7bvl6 Equus caballus (Horse) Uncharacterized protein Equus caballus
human-ABHD6 Homo sapiens (Human) ABHD6 Monoacylglycerol lipase EC: 3.1.1.23 Homo sapiens
hyaae-m4b4d8 Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis) Uncharacterized protein Hyaloperonospora arabidopsidis
hyaae-m4b4e0 Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis) Uncharacterized protein Hyaloperonospora arabidopsidis
latch-h3ayv4 Latimeria chalumnae (West Indian ocean coelacanth) Uncharacterized protein Latimeria chalumnae
lepbp-b0spz3 Leptospira biflexa serovar Patoc Putative triacylglycerol lipase putative signal peptide Leptospira biflexa serovar Patoc
lepme-k5c7u2 Leptospira meyeri Alpha\/beta hydrolase family protein Leptospira meyeri
loxaf-g3thn3 Loxodonta africana (African elephant) Uncharacterized protein Loxodonta africana
macfa-g7nzc0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) ABHD6 Macaca fascicularis
macmu-f7hir7 Macaca mulatta (Rhesus macaque) Uncharacterized protein Macaca mulatta
marah-e4pqc8 Marinobacter adhaerens (strain HP15) Abhydrolase domain-containing protein 6 Marinobacter adhaerens
marhy-h8w622 Marinobacter hydrocarbonoclasticus ATCC 49840 Lipase 1(Triacylglycerol lipase) Marinobacter hydrocarbonoclasticus ATCC 49840
marhy-q36pb8 Marinobacter aquaeolei VT8 AlphaBeta_hydrolase superfamily Marinobacter hydrocarbonoclasticus VT8
marhy-q36qn4 Marinobacter aquaeolei VT8 probable lipase precursor Marinobacter hydrocarbonoclasticus VT8
melga-g1n4i8 Meleagris gallopavo (Common turkey) Uncharacterized protein Meleagris gallopavo
mondo-f7gly2 Monodelphis domestica (Gray short-tailed opossum) Uncharacterized protein Monodelphis domestica
morsp-3lipa Moraxella sp. lip3 gene for lipase 3 Moraxella sp.
mouse-ABHD6 Mus musculus (Mouse) Monoacylglycerol lipase ABHD6 Mus musculus
muspf-m3yzl3 Mustela putorius furo (European domestic ferret) (Mustela furo) Abhydrolase domain containing 6 Mustela putorius furo
myolu-g1pay8 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
nemve-a7su25 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nomle-g1r6t5 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Uncharacterized protein Nomascus leucogenys
olean-q6a2s8 Oleispira antarctica carboxylesterase (EC 3.1.1.1) Oleispira antarctica
oreni-i3iv83 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) Uncharacterized protein Oreochromis niloticus
oreni-i3kl53 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) Uncharacterized protein Oreochromis niloticus
ornan-f6ty74 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
oryla-h2m361 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
oryla-h2mz49 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
otoga-h0wv79 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Uncharacterized protein Otolemur garnettii
pantr-h2qmu8 Pan troglodytes (Chimpanzee) Uncharacterized protein Pan troglodytes
pelsi-k7f828 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) Uncharacterized protein Pelodiscus sinensis
phyit-d0mqp1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein Phytophthora infestans
phyit-d0mqp2 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative Phytophthora infestans
phyrm-h3gbl6.1 Phytophthora ramorum (Sudden oak death agent) Uncharacterized protein Phytophthora ramorum
phyrm-h3gbl6.2 Phytophthora ramorum (Sudden oak death agent) Uncharacterized protein Phytophthora ramorum
phyrm-h3gbl7 Phytophthora ramorum (Sudden oak death agent) Uncharacterized protein Phytophthora ramorum
physp-g4zqn9 Phytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines) Putative uncharacterized protein Phytophthora sojae
pig-f1sgj4 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
ponab-h2pae6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Uncharacterized protein Pongo abelii
pseae-PA2949 Pseudomonas aeruginosa, Pseudomonas sp. esterase (probable lipase) Pseudomonas aeruginosa
psede-m4wy19 Pseudomonas denitrificans ATCC 13867 Putative lipase Pseudomonas denitrificans ATCC 13867
psef1-f6ah52 Pseudomonas fulva (strain 12-X) Acylglycerol lipase Pseudomonas fulva
psef5-q4kej0 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) hydrolase, alpha\/beta hydrolase fold family , putative Pseudomonas fluorescens
psemn-f4dpi6 Pseudomonas mendocina (strain NK-01) Alpha\/beta hydrolase fold protein Pseudomonas mendocina
psemy-a4xvu4 Pseudomonas mendocina (strain ymp) Alpha\/beta hydrolase fold protein Pseudomonas mendocina
psepf-q3kel6 Pseudomonas fluorescens (strain PfO-1) alpha\/beta hydrolase fold precursor Pseudomonas fluorescens
pseps-i7k8x5 Pseudomonas pseudoalcaligenes CECT 5344, EH56 Alpha\/beta hydrolase fold protein Pseudomonas pseudoalcaligenes CECT 5344
pseps-l8mps6 Pseudomonas pseudoalcaligenes KF707 Alpha\/beta hydrolase Pseudomonas pseudoalcaligenes KF707
pseuo-l1hns5 Pseudomonas sp. (strain M1) Putative lipase Pseudomonas sp.
psyck-q1qeu6 Psychrobacter cryohalolentis (strain K5) alpha\/beta hydrolase fold precursor Pcryo_0023 Lip-948 Psychrobacter cryohalolentis
psyim-1lip Psychrobacter immobilis lip gene for lipase Psychrobacter immobilis
pteal-l5k8f5 Pteropus alecto (Black flying fox) Monoacylglycerol lipase ABHD6 Pteropus alecto
pytul-k3wgh2 Pythium ultimum Uncharacterized protein Pythium ultimum
pytul-k3wgh3 Pythium ultimum Uncharacterized protein Pythium ultimum
rabit-g1se63 Oryctolagus cuniculus (Rabbit) Uncharacterized protein Oryctolagus cuniculus
rat-abhd6 Rattus norvegicus (Rat) Abhydrolase domain-containing protein 6 Rattus norvegicus
salsa-b5x3t9 Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 6 Salmo salar
sarha-g3vyq6 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Uncharacterized protein Sarcophilus harrisii
sheha-a0zsg8 Shewanella hanedai (Alteromonas hanedai) Putative uncharacterized protein Shewanella hanedai
shewm-b1kql5 Shewanella woodyi (strain ATCC 51908 \/ MS32) Alpha\/beta hydrolase fold Shewanella woodyi
spetr-i3mpn4 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) Uncharacterized protein Spermophilus tridecemlineatus
sphal-q1gwq0 Sphingopyxis alaskensis (strain DSM 13593 \/ LMG 18877 \/ RB2256) (Sphingomonas alaskensis) Alpha\/beta hydrolase fold Sphingopyxis alaskensis
stiad-e3fww3 Stigmatella aurantiaca (strain DW4\/3-1) Esterase Stigmatella aurantiaca
stiad-q08q48 Stigmatella aurantiaca (strain DW4\/3-1) Esterase Stigmatella aurantiaca
strsp-Q93MV2 Streptococcus sp., Acinetobacter johnsonii lipase (EC 3.1.1.3) Streptococcus sp.
taegu-h0zat6 Taeniopygia guttata (Zebra finch) (Poephila guttata) Uncharacterized protein Taeniopygia guttata
takru-h2spg7 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein ENSTRUP00000014304 Takifugu rubripes
takru-h2ts55 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein Takifugu rubripes
takru-h2ts56 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein ENSTRUP00000027514 Takifugu rubripes
tetng-q4rjy3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetng-q4rli3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tupch-l8y656 Tupaia chinensis (Chinese tree shrew) Monoacylglycerol lipase ABHD6 Tupaia chinensis
vibma-LIP Vibrio marinus (Moritella marina) triacylglycerol acyl hydrolase Vibrio marinus
xenla-q6gll2 Xenopus laevis (African clawed frog) mgc84753 protein Xenopus laevis
xenla-Q7SY73 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xentr-b1wbh7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) LOC100145783 protein Xenopus tropicalis
xentr-f6rff6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein Xenopus tropicalis
xipma-m4a3m2 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
xipma-m4arw7 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
psea4-u3av93 Pseudomonas alcaligenes (strain ATCC 14909 \/ DSM 50342 \/ JCM 20561 \/ NBRC 14159 \/ NCIMB 9945 \/ NCTC 10367 \/ 1577). Putative lipase Pseudomonas alcaligenes

Gene_locus_frgt Name Species
dicla-e6zge8 Dicentrarchus labrax (European seabass) (Morone labrax) Abhydrolase domain-containing protein 6 Dicentrarchus labrax
geosm-c6e6n9 Geobacter sp. (strain M21) Alpha\/beta hydrolase fold protein Geobacter sp.
psefs-c3kbn7 Pseudomonas fluorescens (strain SBW25) Putative uncharacterized protein Pseudomonas fluorescens

Substrate Chemical Nomenclature Proteins
Lyso-PE(16-0.0-0) [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] hexadecanoate pseae-PA2949
PGE2-glyceryl-ester 2,3-dihydroxypropyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoate human-ABHD12    human-ABHD6    human-MGLL    human-CES1
Bis(monoacylglycerol)phosphate [(2S)-2-hydroxy-3-[hydroxy-[(2S)-2-hydroxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropyl] (Z)-octadec-9-enoate human-ABHD6    mouse-ABHD6
Undecanoic-acid undecanoic acid pseae-PA2949
AHMMCE human-MGLL    human-ABHD6
Octylglucoside (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-octoxyoxane-3,4,5-triol aerpe-APE1547    canar-LipB    human-ABHD6    pseae-PA2949    canfa-1lipg
2-Arachidonylglycerol 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate human-MGLL    human-ABHD6    human-ABHD12    mouse-Ces2c    human-CES2    human-ABHD2    pseae-PA2949
Paranitrophenyl-octanoate (4-nitrophenyl) octanoate 9firm-a0a0a0ymq9    9bact-Q0GMU2    psesp-OPH    human-NOTUM    pseae-PA2949    crysp-Q874E9    emeni-q5b2c1    fusso-cutas    thite-g2rae6    9flao-a0a330mq60    9flao-a0a0c1f4u8    malgo-a8puy1    9bact-6EB3    partm-GthFAE    9bact-a0a2h5z9r5    9actn-j7k890    9actn-j7kdc6
Paranitrophenyl-myristate (4-nitrophenyl) tetradecanoate 9gamm-q2ktb4
Arachidonoyl-1-thioglycerol S-(2,3-dihydroxypropyl) (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate human-MGLL    plafa-PF10.0379
Trimyristin 2,3-di(tetradecanoyloxy)propyl tetradecanoate bacld-q65hr4    9gamm-q2ktb4    staha-Q9RGZ6

Inhibitor Chemical Nomenclature Proteins
Glycidyl-Palmitoleate oxiran-2-ylmethyl (Z)-hexadec-9-enoate human-ABHD6
CHEMBL4289712 [(6S)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone human-ABHD6
SCHEMBL19582562 1,1,1,3,3,3-hexafluoropropan-2-yl 2-[(3-chloro-4-morpholin-4-ylphenyl)methyl]-2,8-diazaspiro[4.5]decane-8-carboxylate human-ABHD6
SCHEMBL20516363 [(4R)-2,5-dioxo-4-propan-2-ylimidazolidin-1-yl] 4-[2-chloro-3-(morpholine-4-carbonyl)phenyl]piperazine-1-carboxylate human-ABHD6    human-PLA2G7
MJN193 (2,5-dioxo-4-propan-2-ylimidazolidin-1-yl) 4-(4-methoxyphenyl)piperazine-1-carboxylate human-ABHD6
JZP-430 (4-morpholin-4-yl-1,2,5-thiadiazol-3-yl) N-cyclooctyl-N-methylcarbamate human-ABHD6
JZP-MA-11 human-ABHD6
HT-01 N-[5-[3-[(5Z)-5-[(1-difluoroboranyl-3,5-dimethylpyrrol-2-yl)methylidene]pyrrol-2-yl]propanoylamino]pentyl]-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]triazole-1-carboxamide human-DAGLA    human-DAGLB    human-ABHD6
JCP-265 [(2S)-1-[[3-(2-bromoethoxy)-4-chloro-1-oxoisochromen-7-yl]amino]-1-oxopropan-2-yl] N-phenylcarbamate human-ABHD6
KT185 [3-[4-[1-(2-phenylpiperidine-1-carbonyl)triazol-4-yl]phenyl]phenyl]-piperidin-1-ylmethanone human-ABHD6
KT203 3-[4-[1-(2-benzylpiperidine-1-carbonyl)triazol-4-yl]phenyl]benzoic acid human-ABHD6
KT182 [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone human-ABHD6
LEI-106 2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid human-DAGLA    human-ABHD6
BIA-10-2474 N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide human-CES2    human-ABHD6
Undecanoic-acid undecanoic acid pseae-PA2949
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
Euphol (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
Palmostatin-M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one human-LYPLA1    human-LYPLA2    human-PREPL
Palmostatin-B (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one human-ABHD16A    human-ABHD6    human-FASN    human-ABHD17A    human-ABHD17B    human-ABHD17C    human-LYPLA1    human-LYPLA2    human-PREPL
CAY10499 benzyl N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3-yl)-2-methylphenyl]carbamate human-MGLL
CHEMBL238787 [4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl] 4-(hydroxymethyl)piperidine-1-carboxylate
JZL195 (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate human-MGLL    human-CES1    human-ABHD6
Rhc80267 (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate human-DAGLA    human-DAGLB
JZL184 (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate human-MGLL
KT195 [4-[4-(4-methoxyphenyl)phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone
KT172 (2-benzylpiperidin-1-yl)-[4-[4-(2-methoxyphenyl)phenyl]triazol-1-yl]methanone
KT109 (2-benzylpiperidin-1-yl)-[4-(4-phenylphenyl)triazol-1-yl]methanone
WWL113 ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate human-ABHD6    human-CES3    mouse-Ces1d
WWL123 [3-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate
AM6701 ~{N},~{N}-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide human-ABHD6    human-MGLL
WWL70 [4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate human-ABHD6
VX-Biotin human-CTSA    human-ACHE    human-BCHE
LY2183240 N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide human-MGLL    human-NCEH1    human-ABHD6
Orlistat [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate human-DAGLA    human-DAGLB    human-PNLIP    human-FASN    mycs2-a0r619    human-PNLIPRP2    human-ABHD16A    myctu-a85c    myctu-Rv3822    plafa-PF10.0379    staau-lipas    human-CES2

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Gene_locus related to this paper: human-ABHD6

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Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

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Gene_locus related to this paper: human-ABHD6

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Gene_locus related to this paper: human-ABHD6

Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257
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Gene_locus related to this paper: human-DAGLB

Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270
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Abstract :
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Gene_locus related to this paper: human-ABHD6

Title : High expression of the evolutionarily conserved alpha\/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors - Max_2009_Cancer.Sci_100_2383
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Gene_locus related to this paper: human-ABHD6

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Gene_locus related to this paper: human-ABHD6

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PubMedSearch : Blankman_2007_Chem.Biol_14_1347
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Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : Cloning, expression and characterization of a lipase gene (lip3) from Pseudomonas aeruginosa LST-03 - Ogino_2004_Mol.Genet.Genomics_271_189
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Abstract :
PubMedSearch : Ogino_2004_Mol.Genet.Genomics_271_189
PubMedID: 14740297
Gene_locus related to this paper: pseae-PA2949

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
Abstract :
PubMedSearch : Jaeger_2002_Curr.Opin.Biotechnol_13_390
PubMedID: 12323363

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
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Ref : Biochemical Journal , 343 :177 , 1999
Abstract :
PubMedSearch : Arpigny_1999_Biochem.J_343_177
PubMedID: 10493927

Title : Nucleotide sequence of the lipase gene lip3 from the antarctic psychotroph Moraxella TA144 - Feller_1991_Biochim.Biophys.Acta_1088_323
Author(s) : Feller G , Thiry M , Gerday C
Ref : Biochimica & Biophysica Acta , 1088 :323 , 1991
Abstract :
PubMedSearch : Feller_1991_Biochim.Biophys.Acta_1088_323
PubMedID: 2001407
Gene_locus related to this paper: morsp-3lipa