Zhao_2026_Int.J.Gen.Med_19_622563

OBJECTIVE: This study aims to investigate the association between the single nucleotide polymorphisms (SNPs) rs1800977 and rs2066714 in the ATP-binding cassette transporter A1 (ABCA1) gene, and rs2000813 and rs4939883 in the endothelial lipase (LIPG) gene, with coronary heart disease (CHD) in the Chinese Han population. METHODS: A case-control study was conducted, including 266 CHD patients and 112 controls. Genotyping of the SNPs was performed using PCR and single base extension methods. Allele and genotype frequencies were compared, and sex-stratified analyses were conducted. RESULTS: No significant differences were observed in allele or genotype frequencies for ABCA1 rs1800977, ABCA1 rs2066714, and LIPG rs2000813 between CHD patients and controls in the overall population or sex-stratified analyses. In the overall population, the allele frequency comparisons showed no significant associations for ABCA1 rs1800977 (P = 0.776), ABCA1 rs2066714 (P = 0.609), LIPG rs2000813 (P = 0.824), or LIPG rs4939883 (P = 0.837). In females, the T allele frequency of LIPG rs4939883 was higher in CHD patients than in controls, and the T allele showed a nominal unadjusted association with increased CHD risk (crude OR = 1.735, 95% CI: 1.032-2.915, P = 0.038). CONCLUSION: ABCA1 rs1800977, ABCA1 rs2066714, and LIPG rs2000813 were not significantly associated with CHD susceptibility in this Chinese Han population. LIPG rs4939883 showed a potential sex-specific association with CHD, with the T allele showing a nominal unadjusted association with increased CHD risk in females. This finding should be interpreted cautiously and requires validation in larger independent cohorts.