| Title : Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands - Zheng_2005_Bioorg.Med.Chem.Lett_15_4463 |
| Author(s) : Zheng G , Dwoskin LP , Deaciuc AG , Crooks PA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :4463 , 2005 |
|
Abstract :
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2. |
| PubMedSearch : Zheng_2005_Bioorg.Med.Chem.Lett_15_4463 |
| PubMedID: 16112864 |
Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA (2005)
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands
Bioorganic & Medicinal Chemistry Lett
15 :4463
Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA (2005)
Bioorganic & Medicinal Chemistry Lett
15 :4463